PT882726E - Carbazol-carboxamidas como agonistas 5-ht1f - Google Patents
Carbazol-carboxamidas como agonistas 5-ht1fInfo
- Publication number
- PT882726E PT882726E PT98304343T PT98304343T PT882726E PT 882726 E PT882726 E PT 882726E PT 98304343 T PT98304343 T PT 98304343T PT 98304343 T PT98304343 T PT 98304343T PT 882726 E PT882726 E PT 882726E
- Authority
- PT
- Portugal
- Prior art keywords
- carboxamid
- carbazol
- ht1f agonists
- ht1f
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
- Semiconductor Integrated Circuits (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Insulating Materials (AREA)
- Conductive Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4858497P | 1997-06-04 | 1997-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT882726E true PT882726E (pt) | 2003-09-30 |
Family
ID=21955349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98304343T PT882726E (pt) | 1997-06-04 | 1998-06-02 | Carbazol-carboxamidas como agonistas 5-ht1f |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0882726B1 (pt) |
| JP (1) | JP2002502419A (pt) |
| KR (1) | KR20010013409A (pt) |
| CN (1) | CN1259049A (pt) |
| AT (1) | ATE240953T1 (pt) |
| AU (1) | AU729786B2 (pt) |
| BR (1) | BR9810610A (pt) |
| CA (1) | CA2291624A1 (pt) |
| DE (1) | DE69814735T2 (pt) |
| DK (1) | DK0882726T3 (pt) |
| EA (1) | EA001718B1 (pt) |
| ES (1) | ES2199410T3 (pt) |
| HU (1) | HUP0004142A3 (pt) |
| ID (1) | ID23053A (pt) |
| IL (1) | IL133279A0 (pt) |
| NO (1) | NO995963L (pt) |
| NZ (1) | NZ501569A (pt) |
| PL (1) | PL337221A1 (pt) |
| PT (1) | PT882726E (pt) |
| TR (1) | TR199903014T2 (pt) |
| WO (1) | WO1998055115A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1937300A (en) * | 1998-12-11 | 2000-06-26 | Eli Lilly And Company | Indole derivatives and their use as 5-HT1F agonists |
| AU3840000A (en) | 1999-04-20 | 2000-11-02 | Meiji Seika Kaisha Ltd. | Tricyclic compounds |
| CA2378241A1 (en) | 1999-08-04 | 2001-02-15 | Icagen, Inc. | Benzanilides as potassium channel openers |
| US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| WO2001010381A2 (en) * | 1999-08-04 | 2001-02-15 | Icagen, Inc. | Methods for treating or preventing pain and anxiety |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| CN1777584A (zh) | 2003-04-18 | 2006-05-24 | 伊莱利利公司 | 作为5－ht1f激动剂的(哌啶氧基)苯基、(哌啶氧基)吡啶基、(哌啶硫基)苯基和(哌啶硫基)吡啶基化合物 |
| UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
| DE602004008338T2 (de) * | 2003-12-17 | 2008-05-29 | Eli Lilly And Co., Indianapolis | Substituierte (4-aminocyclohexen-1-yl) phenyl and (4-aminocyclohexen-1-yl) pyridinyl verbindungen als 5-ht1f agonisten |
| CN101243046A (zh) * | 2005-08-08 | 2008-08-13 | 安斯泰来制药有限公司 | 酰基胍衍生物或其盐 |
| WO2008096791A1 (ja) * | 2007-02-07 | 2008-08-14 | Astellas Pharma Inc. | アシルグアニジン誘導体 |
| CN102791689B (zh) * | 2010-03-22 | 2014-10-29 | 埃科特莱茵药品有限公司 | 3-（杂芳基-氨基）-1,2,3,4-四氢-9h-咔唑衍生物及其作为前列腺素d2受体调节剂的用途 |
| CA2795062A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
| US20160051526A1 (en) * | 2013-04-09 | 2016-02-25 | Cresset Biomolecular Discovery Ltd | The Local Treatment of Inflammatory Ophthalmic Disorders |
| TWI829107B (zh) | 2019-07-09 | 2024-01-11 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
| CN112125836A (zh) * | 2020-10-15 | 2020-12-25 | 濮阳惠成电子材料股份有限公司 | 有机电致光电材料中间体n-苯基咔唑-3-羧酸乙酯的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| CA2215322A1 (en) * | 1995-03-20 | 1996-09-26 | Stephen Warren Kaldor | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
| ES2151993T3 (es) * | 1995-06-23 | 2001-01-16 | Lilly Co Eli | 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos. |
-
1998
- 1998-01-06 ID IDW991411A patent/ID23053A/id unknown
- 1998-06-01 PL PL98337221A patent/PL337221A1/xx unknown
- 1998-06-01 JP JP50237299A patent/JP2002502419A/ja not_active Ceased
- 1998-06-01 TR TR1999/03014T patent/TR199903014T2/xx unknown
- 1998-06-01 CA CA002291624A patent/CA2291624A1/en not_active Abandoned
- 1998-06-01 AU AU77955/98A patent/AU729786B2/en not_active Ceased
- 1998-06-01 IL IL13327998A patent/IL133279A0/xx unknown
- 1998-06-01 NZ NZ501569A patent/NZ501569A/en unknown
- 1998-06-01 EA EA199901113A patent/EA001718B1/ru not_active IP Right Cessation
- 1998-06-01 HU HU0004142A patent/HUP0004142A3/hu unknown
- 1998-06-01 BR BR9810610-4A patent/BR9810610A/pt not_active IP Right Cessation
- 1998-06-01 CN CN98805776A patent/CN1259049A/zh active Pending
- 1998-06-01 KR KR19997011410A patent/KR20010013409A/ko not_active Application Discontinuation
- 1998-06-01 WO PCT/US1998/003340 patent/WO1998055115A1/en not_active Application Discontinuation
- 1998-06-02 EP EP98304343A patent/EP0882726B1/en not_active Expired - Lifetime
- 1998-06-02 ES ES98304343T patent/ES2199410T3/es not_active Expired - Lifetime
- 1998-06-02 DK DK98304343T patent/DK0882726T3/da active
- 1998-06-02 AT AT98304343T patent/ATE240953T1/de not_active IP Right Cessation
- 1998-06-02 DE DE69814735T patent/DE69814735T2/de not_active Expired - Fee Related
- 1998-06-02 PT PT98304343T patent/PT882726E/pt unknown
-
1999
- 1999-12-03 NO NO995963A patent/NO995963L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004142A2 (hu) | 2001-05-28 |
| EA199901113A1 (ru) | 2000-08-28 |
| ID23053A (id) | 2000-01-20 |
| BR9810610A (pt) | 2000-09-12 |
| NZ501569A (en) | 2001-11-30 |
| KR20010013409A (ko) | 2001-02-26 |
| CN1259049A (zh) | 2000-07-05 |
| CA2291624A1 (en) | 1998-12-10 |
| EP0882726A1 (en) | 1998-12-09 |
| DE69814735T2 (de) | 2004-03-25 |
| EA001718B1 (ru) | 2001-08-27 |
| PL337221A1 (en) | 2000-08-14 |
| NO995963D0 (no) | 1999-12-03 |
| DE69814735D1 (de) | 2003-06-26 |
| AU729786B2 (en) | 2001-02-08 |
| HUP0004142A3 (en) | 2002-10-28 |
| IL133279A0 (en) | 2001-04-30 |
| AU7795598A (en) | 1998-12-21 |
| JP2002502419A (ja) | 2002-01-22 |
| TR199903014T2 (xx) | 2000-05-22 |
| ES2199410T3 (es) | 2004-02-16 |
| NO995963L (no) | 1999-12-03 |
| DK0882726T3 (da) | 2003-09-22 |
| WO1998055115A1 (en) | 1998-12-10 |
| ATE240953T1 (de) | 2003-06-15 |
| EP0882726B1 (en) | 2003-05-21 |
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