NO995963L - Karboksamider anvendelige som 5-HTIF-agonister - Google Patents
Karboksamider anvendelige som 5-HTIF-agonisterInfo
- Publication number
- NO995963L NO995963L NO995963A NO995963A NO995963L NO 995963 L NO995963 L NO 995963L NO 995963 A NO995963 A NO 995963A NO 995963 A NO995963 A NO 995963A NO 995963 L NO995963 L NO 995963L
- Authority
- NO
- Norway
- Prior art keywords
- carboxamides
- carboxamides useful
- htif
- agonists
- htif agonists
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 150000003857 carboxamides Chemical class 0.000 title 1
- -1 3-amino-1H-cyclohepta [7,6-b] indole-7-carboxamides Chemical class 0.000 abstract 1
- GZJDNSCLZKOHHP-UHFFFAOYSA-N 7-amino-6,7,8,9-tetrahydro-5h-carbazole-3-carboxamide Chemical class N1C2=CC=C(C(N)=O)C=C2C2=C1CC(N)CC2 GZJDNSCLZKOHHP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Den foreliggende oppfinnelsen tilveiebringer nye 2-amino-l,2,3,4-tetrahydro-9H- karbazol-6-karboksamider og 3-amino-1 OH-cyklohepta[7,6-b]indol-7-karboksamider med formel (I), hvor R1, R2, R3 og n er som beskrevet i beskrivelsen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4858497P | 1997-06-04 | 1997-06-04 | |
PCT/US1998/003340 WO1998055115A1 (en) | 1997-06-04 | 1998-06-01 | Carboxamides useful as 5-ht1f agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
NO995963L true NO995963L (no) | 1999-12-03 |
NO995963D0 NO995963D0 (no) | 1999-12-03 |
Family
ID=21955349
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO995963A NO995963D0 (no) | 1997-06-04 | 1999-12-03 | Karboksamider anvendelige som 5-HTIF-agonister |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0882726B1 (no) |
JP (1) | JP2002502419A (no) |
KR (1) | KR20010013409A (no) |
CN (1) | CN1259049A (no) |
AT (1) | ATE240953T1 (no) |
AU (1) | AU729786B2 (no) |
BR (1) | BR9810610A (no) |
CA (1) | CA2291624A1 (no) |
DE (1) | DE69814735T2 (no) |
DK (1) | DK0882726T3 (no) |
EA (1) | EA001718B1 (no) |
ES (1) | ES2199410T3 (no) |
HU (1) | HUP0004142A3 (no) |
ID (1) | ID23053A (no) |
IL (1) | IL133279A0 (no) |
NO (1) | NO995963D0 (no) |
NZ (1) | NZ501569A (no) |
PL (1) | PL337221A1 (no) |
PT (1) | PT882726E (no) |
TR (1) | TR199903014T2 (no) |
WO (1) | WO1998055115A1 (no) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000034266A1 (en) * | 1998-12-11 | 2000-06-15 | Eli Lilly And Company | Indole derivatives and their use as 5-ht1f agonists |
AU3840000A (en) | 1999-04-20 | 2000-11-02 | Meiji Seika Kaisha Ltd. | Tricyclic compounds |
WO2001010381A2 (en) * | 1999-08-04 | 2001-02-15 | Icagen, Inc. | Methods for treating or preventing pain and anxiety |
US6495550B2 (en) | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
ATE380176T1 (de) | 1999-08-04 | 2007-12-15 | Icagen Inc | Benzanilide als öffner des kaliumkanals |
TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
CN1777584A (zh) | 2003-04-18 | 2006-05-24 | 伊莱利利公司 | 作为5-ht1f激动剂的(哌啶氧基)苯基、(哌啶氧基)吡啶基、(哌啶硫基)苯基和(哌啶硫基)吡啶基化合物 |
UA82711C2 (en) | 2003-09-12 | 2008-05-12 | Эли Лилли Энд Компани | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists |
WO2005061439A1 (en) * | 2003-12-17 | 2005-07-07 | Eli Lilly And Company | Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists |
KR20080044273A (ko) | 2005-08-08 | 2008-05-20 | 아스텔라스세이야쿠 가부시키가이샤 | 아실구아니딘 유도체 또는 그의 염 |
JP5287257B2 (ja) * | 2007-02-07 | 2013-09-11 | アステラス製薬株式会社 | アシルグアニジン誘導体 |
WO2011117798A1 (en) * | 2010-03-22 | 2011-09-29 | Actelion Pharmaceuticals Ltd | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators |
CA2795062A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
CA2909111A1 (en) * | 2013-04-09 | 2014-10-16 | Cresset Biomolecular Discovery Ltd | The local treatment of inflammatory ophthalmic diseases |
AR119319A1 (es) | 2019-07-09 | 2021-12-09 | Lilly Co Eli | Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida |
CN112125836A (zh) * | 2020-10-15 | 2020-12-25 | 濮阳惠成电子材料股份有限公司 | 有机电致光电材料中间体n-苯基咔唑-3-羧酸乙酯的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
EA001113B1 (ru) * | 1995-03-20 | 2000-10-30 | Эли Лилли Энд Компани | 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации |
DE69610793T2 (de) * | 1995-06-23 | 2001-05-03 | Lilly Co Eli | 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole |
-
1998
- 1998-01-06 ID IDW991411A patent/ID23053A/id unknown
- 1998-06-01 HU HU0004142A patent/HUP0004142A3/hu unknown
- 1998-06-01 KR KR19997011410A patent/KR20010013409A/ko not_active Application Discontinuation
- 1998-06-01 TR TR1999/03014T patent/TR199903014T2/xx unknown
- 1998-06-01 IL IL13327998A patent/IL133279A0/xx unknown
- 1998-06-01 PL PL98337221A patent/PL337221A1/xx unknown
- 1998-06-01 NZ NZ501569A patent/NZ501569A/en unknown
- 1998-06-01 CA CA002291624A patent/CA2291624A1/en not_active Abandoned
- 1998-06-01 JP JP50237299A patent/JP2002502419A/ja not_active Ceased
- 1998-06-01 BR BR9810610-4A patent/BR9810610A/pt not_active IP Right Cessation
- 1998-06-01 AU AU77955/98A patent/AU729786B2/en not_active Ceased
- 1998-06-01 WO PCT/US1998/003340 patent/WO1998055115A1/en not_active Application Discontinuation
- 1998-06-01 CN CN98805776A patent/CN1259049A/zh active Pending
- 1998-06-01 EA EA199901113A patent/EA001718B1/ru not_active IP Right Cessation
- 1998-06-02 DK DK98304343T patent/DK0882726T3/da active
- 1998-06-02 DE DE69814735T patent/DE69814735T2/de not_active Expired - Fee Related
- 1998-06-02 ES ES98304343T patent/ES2199410T3/es not_active Expired - Lifetime
- 1998-06-02 PT PT98304343T patent/PT882726E/pt unknown
- 1998-06-02 EP EP98304343A patent/EP0882726B1/en not_active Expired - Lifetime
- 1998-06-02 AT AT98304343T patent/ATE240953T1/de not_active IP Right Cessation
-
1999
- 1999-12-03 NO NO995963A patent/NO995963D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ID23053A (id) | 2000-01-20 |
PT882726E (pt) | 2003-09-30 |
WO1998055115A1 (en) | 1998-12-10 |
EA199901113A1 (ru) | 2000-08-28 |
CN1259049A (zh) | 2000-07-05 |
HUP0004142A2 (hu) | 2001-05-28 |
EP0882726B1 (en) | 2003-05-21 |
ES2199410T3 (es) | 2004-02-16 |
NO995963D0 (no) | 1999-12-03 |
HUP0004142A3 (en) | 2002-10-28 |
NZ501569A (en) | 2001-11-30 |
AU729786B2 (en) | 2001-02-08 |
KR20010013409A (ko) | 2001-02-26 |
AU7795598A (en) | 1998-12-21 |
EP0882726A1 (en) | 1998-12-09 |
DE69814735D1 (de) | 2003-06-26 |
DE69814735T2 (de) | 2004-03-25 |
JP2002502419A (ja) | 2002-01-22 |
ATE240953T1 (de) | 2003-06-15 |
PL337221A1 (en) | 2000-08-14 |
EA001718B1 (ru) | 2001-08-27 |
BR9810610A (pt) | 2000-09-12 |
TR199903014T2 (xx) | 2000-05-22 |
DK0882726T3 (da) | 2003-09-22 |
CA2291624A1 (en) | 1998-12-10 |
IL133279A0 (en) | 2001-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |