DK0882726T3 - Carbazolcarboxamider som 5-HT1F-agonister - Google Patents

Carbazolcarboxamider som 5-HT1F-agonister

Info

Publication number
DK0882726T3
DK0882726T3 DK98304343T DK98304343T DK0882726T3 DK 0882726 T3 DK0882726 T3 DK 0882726T3 DK 98304343 T DK98304343 T DK 98304343T DK 98304343 T DK98304343 T DK 98304343T DK 0882726 T3 DK0882726 T3 DK 0882726T3
Authority
DK
Denmark
Prior art keywords
carboxamides
carbazole
ht1f agonists
ht1f
agonists
Prior art date
Application number
DK98304343T
Other languages
Danish (da)
English (en)
Inventor
Michael Edward Flaugh
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0882726T3 publication Critical patent/DK0882726T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/94[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Organic Insulating Materials (AREA)
  • Conductive Materials (AREA)
  • Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK98304343T 1997-06-04 1998-06-02 Carbazolcarboxamider som 5-HT1F-agonister DK0882726T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4858497P 1997-06-04 1997-06-04

Publications (1)

Publication Number Publication Date
DK0882726T3 true DK0882726T3 (da) 2003-09-22

Family

ID=21955349

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98304343T DK0882726T3 (da) 1997-06-04 1998-06-02 Carbazolcarboxamider som 5-HT1F-agonister

Country Status (21)

Country Link
EP (1) EP0882726B1 (no)
JP (1) JP2002502419A (no)
KR (1) KR20010013409A (no)
CN (1) CN1259049A (no)
AT (1) ATE240953T1 (no)
AU (1) AU729786B2 (no)
BR (1) BR9810610A (no)
CA (1) CA2291624A1 (no)
DE (1) DE69814735T2 (no)
DK (1) DK0882726T3 (no)
EA (1) EA001718B1 (no)
ES (1) ES2199410T3 (no)
HU (1) HUP0004142A3 (no)
ID (1) ID23053A (no)
IL (1) IL133279A0 (no)
NO (1) NO995963L (no)
NZ (1) NZ501569A (no)
PL (1) PL337221A1 (no)
PT (1) PT882726E (no)
TR (1) TR199903014T2 (no)
WO (1) WO1998055115A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034266A1 (en) * 1998-12-11 2000-06-15 Eli Lilly And Company Indole derivatives and their use as 5-ht1f agonists
EP1184373A4 (en) 1999-04-20 2004-10-20 Meiji Seika Kaisha TRICYCLIC CONNECTIONS
AU779034B2 (en) 1999-08-04 2005-01-06 Icagen, Inc. Benzanilides as potassium channel openers
US6495550B2 (en) 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
BR0012934A (pt) * 1999-08-04 2003-07-29 Icagen Inc Processos para a redução de dor e de ansiedade
TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
US7608629B2 (en) 2003-04-18 2009-10-27 Eli Lilly And Company (Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists
UA82711C2 (en) 2003-09-12 2008-05-12 Эли Лилли Энд Компани Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht1f agonists
EP1697305B1 (en) 2003-12-17 2007-08-15 Eli Lilly And Company Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-ht1f agonists
JP5092746B2 (ja) 2005-08-08 2012-12-05 アステラス製薬株式会社 アシルグアニジン誘導体またはその塩
CA2677995A1 (en) * 2007-02-07 2008-08-14 Astellas Pharma Inc. Acylguanidine derivative
RU2562255C2 (ru) * 2010-03-22 2015-09-10 Актелион Фармасьютиклз Лтд Производные 3-(гетероариламино)-1,2,3,4-тетрагидро-9н-карбазола и их применение в качестве модуляторов рецепторов простагландина d2
WO2011123654A1 (en) 2010-04-02 2011-10-06 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists
JP2016516761A (ja) * 2013-04-09 2016-06-09 クレスセット バイオモレキュラー ディスカバリー リミテッド 炎症性眼疾患の局所治療
TWI776175B (zh) 2019-07-09 2022-09-01 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體,以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
CN112125836A (zh) * 2020-10-15 2020-12-25 濮阳惠成电子材料股份有限公司 有机电致光电材料中间体n-苯基咔唑-3-羧酸乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
WO1996029075A1 (en) * 1995-03-20 1996-09-26 Eli Lilly And Company 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists
EP0749962B1 (en) * 1995-06-23 2000-11-02 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles

Also Published As

Publication number Publication date
ID23053A (id) 2000-01-20
HUP0004142A2 (hu) 2001-05-28
HUP0004142A3 (en) 2002-10-28
PT882726E (pt) 2003-09-30
EP0882726A1 (en) 1998-12-09
ATE240953T1 (de) 2003-06-15
PL337221A1 (en) 2000-08-14
DE69814735T2 (de) 2004-03-25
AU7795598A (en) 1998-12-21
CA2291624A1 (en) 1998-12-10
NZ501569A (en) 2001-11-30
EA199901113A1 (ru) 2000-08-28
WO1998055115A1 (en) 1998-12-10
EA001718B1 (ru) 2001-08-27
JP2002502419A (ja) 2002-01-22
KR20010013409A (ko) 2001-02-26
NO995963D0 (no) 1999-12-03
TR199903014T2 (xx) 2000-05-22
AU729786B2 (en) 2001-02-08
DE69814735D1 (de) 2003-06-26
IL133279A0 (en) 2001-04-30
NO995963L (no) 1999-12-03
BR9810610A (pt) 2000-09-12
EP0882726B1 (en) 2003-05-21
CN1259049A (zh) 2000-07-05
ES2199410T3 (es) 2004-02-16

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