BR0012327A - Pirrolidinas e piperidinas neurotróficas, e composições e métodos relacionados - Google Patents

Pirrolidinas e piperidinas neurotróficas, e composições e métodos relacionados

Info

Publication number
BR0012327A
BR0012327A BR0012327-7A BR0012327A BR0012327A BR 0012327 A BR0012327 A BR 0012327A BR 0012327 A BR0012327 A BR 0012327A BR 0012327 A BR0012327 A BR 0012327A
Authority
BR
Brazil
Prior art keywords
methods
neurotrophic
pyrrolidines
piperidines
related compositions
Prior art date
Application number
BR0012327-7A
Other languages
English (en)
Inventor
Ramesh M Kanojia
Alfonso D Jordan
Allen B Reitz
Mary J Macielag
Boyu Zhao
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0012327A publication Critical patent/BR0012327A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"PIRROLIDINAS E PIPERIDINAS NEUROTRóFICAS, E COMPOSIçõES E MéTODOS RELACIONADOS". Esta invenção refere-se a compostos tendo as estruturas gerais (I), (II), (III). Esta invenção também fornece composições farmacêuticas compreendendo os mesmos e métodos de empregar estas composições para tratar e prevenir distúrbios caracterizados por dano neuronal.
BR0012327-7A 1999-07-09 2000-06-14 Pirrolidinas e piperidinas neurotróficas, e composições e métodos relacionados BR0012327A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14300699P 1999-07-09 1999-07-09
PCT/US2000/016221 WO2001004116A2 (en) 1999-07-09 2000-06-14 Neurotrophic pyrrolidines and piperidines, and related compositions containing them

Publications (1)

Publication Number Publication Date
BR0012327A true BR0012327A (pt) 2002-07-02

Family

ID=22502172

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012327-7A BR0012327A (pt) 1999-07-09 2000-06-14 Pirrolidinas e piperidinas neurotróficas, e composições e métodos relacionados

Country Status (17)

Country Link
US (1) US6809107B1 (pt)
EP (1) EP1202990A2 (pt)
JP (1) JP2003504367A (pt)
KR (1) KR20020027486A (pt)
CN (1) CN1382140A (pt)
AR (1) AR034541A1 (pt)
AU (1) AU781235B2 (pt)
BR (1) BR0012327A (pt)
CA (1) CA2379149A1 (pt)
CZ (1) CZ200265A3 (pt)
HU (1) HUP0202249A3 (pt)
IL (2) IL147505A0 (pt)
MX (1) MXPA02000330A (pt)
PL (1) PL352432A1 (pt)
RU (1) RU2241709C2 (pt)
TW (1) TW589311B (pt)
WO (1) WO2001004116A2 (pt)

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FR2835254B1 (fr) * 2002-01-25 2006-04-07 Sod Conseils Rech Applic Derives de thiazoles dans le traitement de maladies neurologiques
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
SI1551835T1 (sl) * 2002-09-30 2007-06-30 Neurosearch As Novi 1,4-diazabicikloalkanski derivati, njihova priprava in uporaba
US7189746B2 (en) * 2002-11-08 2007-03-13 Gliamed, Inc. Methods for promoting wound healing
US20040266811A1 (en) * 2002-11-08 2004-12-30 Weinstein David E. Methods for inducing regeneration, remyelination, and hypermyelination of nervous tissue
WO2006116808A1 (en) * 2005-04-29 2006-11-09 Metabolic Pharmaceuticals Limited Treating peripheral neuropathies
US20080015236A1 (en) * 2006-02-08 2008-01-17 Weinstein David E Method for promoting myocardial regeneration and uses thereof
US7795216B2 (en) * 2006-03-24 2010-09-14 Glia Med, Inc. Methods for promoting composite tissue regeneration and uses thereof
GB0701426D0 (en) * 2007-01-25 2007-03-07 Univ Sheffield Compounds and their use
TWI534142B (zh) * 2011-03-15 2016-05-21 大正製藥股份有限公司 Azole derivatives
SG11201601682RA (en) * 2013-09-06 2016-04-28 Aurigene Discovery Tech Ltd 1,2,4-oxadiazole derivatives as immunomodulators
KR102526625B1 (ko) * 2014-12-17 2023-04-27 킹즈 컬리지 런던 레티노산 수용체 베타 (RARβ) 작동제로서 바이사이클로헤테로아릴-헤테로아릴-벤조산 화합물
JP6951336B2 (ja) * 2015-12-04 2021-10-20 ザ ペン ステイト リサーチ ファウンデーション 小分子カクテルによるヒトグリア細胞からニューロンへの化学的リプログラミング
CN114591295B (zh) * 2022-03-04 2023-11-07 贵州大学 含吡啶盐的n-(吲哚酰基)-n’-(取代的)的丙基酰肼类衍生物、其制备方法及应用

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US4950649A (en) 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
DE3721534A1 (de) * 1986-08-02 1988-02-11 Basf Ag Thiadiazolgruppen enthaltende polymere und deren verwendung in der elektroindustrie
HU217621B (hu) 1991-05-09 2000-03-28 Vertex Pharmaceuticals Inc. Eljárás új glioxaloil-pipekolinsav-észterek, származékaik és az ezeket tartalmazó gyógyszerkészítmények előállítására
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
US5621101A (en) 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5756494A (en) 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
NZ314207A (en) 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
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US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
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JP4936345B2 (ja) 1996-02-28 2012-05-23 アリアド・ファーマシューティカルズ・インコーポレイテッド イムノフィリン由来ドメインとのキメラタンパク質用の多量体化剤としてのラパマイシンの合成誘導体
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US5935989A (en) * 1996-12-31 1999-08-10 Gpi Nil Holdings Inc. N-linked ureas and carbamates of heterocyclic thioesters
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ZA98825B (en) 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
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AU742040C (en) * 1997-09-24 2003-10-02 Amgen, Inc. Method for preventing and treating hearing loss using sensorineurotrophic compounds
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JP4722288B2 (ja) * 1998-06-03 2011-07-13 ジーピーアイ ニル ホールディングス インコーポレイテッド 神経学上の傷害および毛髪損失を治療するために使用されるａｚａ−複素環式化合物
JP2002516903A (ja) * 1998-06-03 2002-06-11 ジーピーアイ ニル ホールディングス インコーポレイテッド Ｎ−複素環式カルボキシル酸およびカルボキシル酸等配電子体の尿素およびカルバメート
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Also Published As

Publication number Publication date
HUP0202249A3 (en) 2003-01-28
CN1382140A (zh) 2002-11-27
PL352432A1 (en) 2003-08-25
KR20020027486A (ko) 2002-04-13
AU5485500A (en) 2001-01-30
CZ200265A3 (cs) 2002-07-17
WO2001004116A3 (en) 2001-08-23
AU781235B2 (en) 2005-05-12
TW589311B (en) 2004-06-01
US6809107B1 (en) 2004-10-26
IL147505A (en) 2006-07-05
EP1202990A2 (en) 2002-05-08
RU2241709C2 (ru) 2004-12-10
JP2003504367A (ja) 2003-02-04
HUP0202249A2 (hu) 2002-12-28
IL147505A0 (en) 2002-08-14
AR034541A1 (es) 2004-03-03
WO2001004116A2 (en) 2001-01-18
MXPA02000330A (es) 2004-05-21
CA2379149A1 (en) 2001-01-18

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements