PT1017681E - Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios - Google Patents

Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios

Info

Publication number
PT1017681E
PT1017681E PT98945363T PT98945363T PT1017681E PT 1017681 E PT1017681 E PT 1017681E PT 98945363 T PT98945363 T PT 98945363T PT 98945363 T PT98945363 T PT 98945363T PT 1017681 E PT1017681 E PT 1017681E
Authority
PT
Portugal
Prior art keywords
pharmaceutical
intermediate compounds
compounds
formulawherein
substituents
Prior art date
Application number
PT98945363T
Other languages
English (en)
Inventor
Francois Goubet
Jean-Francois Gourvest
Carniato Dr Denis
Mcdowell Dr Robert
Karl-Heinz Scheunemann
Thomas R Gadek
Jochen Knolle
Original Assignee
Genentech Inc
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Aventis Pharma Sa filed Critical Genentech Inc
Publication of PT1017681E publication Critical patent/PT1017681E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02Monothiocarbamic acids; Derivatives thereof
    • C07C333/04Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44Nitrogen atoms not forming part of a nitro radical
    • C07D233/52Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
PT98945363T 1997-09-24 1998-09-23 Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios PT1017681E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9711859A FR2768734B1 (fr) 1997-09-24 1997-09-24 Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
PT1017681E true PT1017681E (pt) 2004-06-30

Family

ID=9511409

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98945363T PT1017681E (pt) 1997-09-24 1998-09-23 Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios

Country Status (11)

Country Link
US (1) US6277845B1 (pt)
EP (1) EP1017681B1 (pt)
JP (1) JP4493839B2 (pt)
AT (1) ATE236885T1 (pt)
AU (1) AU9270598A (pt)
DE (1) DE69813263T2 (pt)
DK (1) DK1017681T3 (pt)
ES (1) ES2192789T3 (pt)
FR (1) FR2768734B1 (pt)
PT (1) PT1017681E (pt)
WO (1) WO1999015507A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768736B1 (fr) * 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
KR100861466B1 (ko) 2001-04-24 2008-10-02 메르크 파텐트 게엠베하 항혈관형성제 및 TNFα를 이용한 병용 요법
JP2009523813A (ja) 2006-01-18 2009-06-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためにインテグリンのリガンドを使用する特異的な治療法
KR20090108713A (ko) 2007-01-18 2009-10-16 메르크 파텐트 게엠베하 인테그린 리간드를 사용하는 암치료용 특이적 요법 및 의약
WO2010068371A2 (en) * 2008-12-11 2010-06-17 University Of Georgia Research Foundation, Inc. Preparation of alkenes by mild thermolysis of sulfoxides
NZ597339A (en) 2009-05-25 2013-10-25 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
CN106572997A (zh) 2014-05-30 2017-04-19 辉瑞公司 作为选择性雄激素受体调节剂的腈衍生物
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10504825A (ja) * 1994-08-22 1998-05-12 スミスクライン・ビーチャム・コーポレイション 二環式化合物
FR2731217B1 (fr) * 1995-03-03 1997-06-13 Roussel Uclaf Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires
GEP20012516B (en) * 1996-03-20 2001-08-27 Genentech Inc Tricyclic Compounds Having Activity Specific for Integring, Particularly , avB3 Integrins, Method for Preparation the Same as Drugs and Pharmaceutical Composition Containing Same
DE19629817A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten

Also Published As

Publication number Publication date
US6277845B1 (en) 2001-08-21
DK1017681T3 (da) 2003-07-14
FR2768734B1 (fr) 2000-01-28
ES2192789T3 (es) 2003-10-16
JP2001517657A (ja) 2001-10-09
FR2768734A1 (fr) 1999-03-26
DE69813263D1 (de) 2003-05-15
EP1017681A1 (fr) 2000-07-12
ATE236885T1 (de) 2003-04-15
JP4493839B2 (ja) 2010-06-30
AU9270598A (en) 1999-04-12
EP1017681B1 (fr) 2003-04-09
DE69813263T2 (de) 2004-01-29
WO1999015507A1 (fr) 1999-04-01

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