AR034541A1 - Pirrolidinas y piperidinas neurotrofas y composiciones farmaceuticas y el uso de las mismas para preparar un medicamento - Google Patents

Pirrolidinas y piperidinas neurotrofas y composiciones farmaceuticas y el uso de las mismas para preparar un medicamento

Info

Publication number
AR034541A1
AR034541A1 ARP000103484A ARP000103484A AR034541A1 AR 034541 A1 AR034541 A1 AR 034541A1 AR P000103484 A ARP000103484 A AR P000103484A AR P000103484 A ARP000103484 A AR P000103484A AR 034541 A1 AR034541 A1 AR 034541A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
phenyl
branched
linear
Prior art date
Application number
ARP000103484A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of AR034541A1 publication Critical patent/AR034541A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Pirrolidinas y piperidinas que tienen la estructura de fórmula (1) o sales farmacéuticamente aceptables de las mismas, en donde: R1 está seleccionado a partir del grupo formado por H, COCOR2, COOR3 y SO2R3; estando R2 seleccionado a partir del grupo formado por O-alquilo C1-6 lineal o ramificado, alquilo C1-6 lineal o ramificado, alquenilo C1-6 lineal o ramificado, cicloalquilo C5-7, 2-tienilo, 3-tienilo o fenilo, teniendo el fenilo de uno a tres sustituyentes independientemente seleccionados a partir del grupo formado por H, alquilo inferior, alcoxilo inferior, hidroxilo y halógeno; y siendo R3 fenilalquilo, teniendo el fenilo de uno a tres sustituyentes independientemente seleccionados a partir del grupo formado por H, alquilo inferior, alcoxilo inferior, hidroxilo y halógeno; el anillo que contiene al nitrógeno es un anillo heterocíclico de 4 a 6 miembros, en donde no más de un átomo del anillo es O ó S; X es un anillo heterocíclico de 5 miembros que tiene de dos a tres heteroátomos seleccionados a partir del grupo formado por N, O, y S, siendo por lo menos uno de dichos heteroátomos, N; y A está seleccionado a partir del grupo formado por COO(CH2)mAr, un resto de fórmula (2), (teniendo dicho R1 el mismo o diferente significado que el R1 descripto más arriba, CONR4(CH2)mAr, (CH2)mO(CH2)nAr y (CH2)nAr; siendo R4, H o alquilo C1-4; estando Ar seleccionado a partir del grupo formado por 2-piridilo, 3-piridilo, 4-piridilo y fenilo, teniendo el fenilo entre uno y tres sustituyentes independientemente seleccionados a partir del grupo formado por H, alquilo inferior, alcoxilo inferior, hidroxilo y halógeno; siendo m de 1-4; y siendo n de 0-4. Además, se dan a conocer pirrolidinas y piperidinas que tienen las estructuras de fórmulas (3) y (4) o sales farmacéuticamente aceptables de las mismas, en donde: R'' es alquilo C1-4 lineal o ramificado; R1, R2, R3, X, y el anillo que contiene nitrógeno son como se definieron anteriormente; B es (CH2)nAr o un resto de fórmula (2); y n es 0-4. Estos compuestos tienen actividad neurótrofa y son útiles en el tratamiento y prevención de los trastornos neuronales tales como la enfermedad de Parkinson, la enfermedad de Alzheimer, los accidentes cerebro-vasculares, la esclerosis múltiple, la esclerosis amiotrófica lateral, la neuropatía diabética y la parálisis de Bell. También se dan a conocer: composiciones farmacéuticas que los comprenden y el uso de tales compuestos y composiciones para la manufactura de medicamentos.
ARP000103484A 1999-07-09 2000-07-07 Pirrolidinas y piperidinas neurotrofas y composiciones farmaceuticas y el uso de las mismas para preparar un medicamento AR034541A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14300699P 1999-07-09 1999-07-09

Publications (1)

Publication Number Publication Date
AR034541A1 true AR034541A1 (es) 2004-03-03

Family

ID=22502172

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103484A AR034541A1 (es) 1999-07-09 2000-07-07 Pirrolidinas y piperidinas neurotrofas y composiciones farmaceuticas y el uso de las mismas para preparar un medicamento

Country Status (17)

Country Link
US (1) US6809107B1 (es)
EP (1) EP1202990A2 (es)
JP (1) JP2003504367A (es)
KR (1) KR20020027486A (es)
CN (1) CN1382140A (es)
AR (1) AR034541A1 (es)
AU (1) AU781235B2 (es)
BR (1) BR0012327A (es)
CA (1) CA2379149A1 (es)
CZ (1) CZ200265A3 (es)
HU (1) HUP0202249A3 (es)
IL (2) IL147505A0 (es)
MX (1) MXPA02000330A (es)
PL (1) PL352432A1 (es)
RU (1) RU2241709C2 (es)
TW (1) TW589311B (es)
WO (1) WO2001004116A2 (es)

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FR2835254B1 (fr) * 2002-01-25 2006-04-07 Sod Conseils Rech Applic Derives de thiazoles dans le traitement de maladies neurologiques
DE10240818A1 (de) * 2002-08-30 2004-05-13 Grünenthal GmbH Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate
SI1551835T1 (sl) * 2002-09-30 2007-06-30 Neurosearch As Novi 1,4-diazabicikloalkanski derivati, njihova priprava in uporaba
US7189746B2 (en) * 2002-11-08 2007-03-13 Gliamed, Inc. Methods for promoting wound healing
US20040266811A1 (en) * 2002-11-08 2004-12-30 Weinstein David E. Methods for inducing regeneration, remyelination, and hypermyelination of nervous tissue
WO2006116808A1 (en) * 2005-04-29 2006-11-09 Metabolic Pharmaceuticals Limited Treating peripheral neuropathies
US20080015236A1 (en) * 2006-02-08 2008-01-17 Weinstein David E Method for promoting myocardial regeneration and uses thereof
US7795216B2 (en) * 2006-03-24 2010-09-14 Glia Med, Inc. Methods for promoting composite tissue regeneration and uses thereof
GB0701426D0 (en) * 2007-01-25 2007-03-07 Univ Sheffield Compounds and their use
TWI534142B (zh) * 2011-03-15 2016-05-21 大正製藥股份有限公司 Azole derivatives
ES2788848T3 (es) * 2013-09-06 2020-10-23 Aurigene Discovery Tech Ltd Derivados de 1,2,4-oxadiazol como inmunomoduladores
WO2016097004A1 (en) * 2014-12-17 2016-06-23 King's College London BICYCLOHETEROARYL-HETEROARYL-BENZOIC ACID COMPOUNDS AS RETINOIC ACID RECEPTOR BETA (RARβ) AGONISTS
US9885015B2 (en) * 2015-12-04 2018-02-06 The Penn State Research Foundation Chemical reprogramming of human glial cells into neurons with small molecule cocktail
CN114591295B (zh) * 2022-03-04 2023-11-07 贵州大学 含吡啶盐的n-(吲哚酰基)-n’-(取代的)的丙基酰肼类衍生物、其制备方法及应用

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Also Published As

Publication number Publication date
CZ200265A3 (cs) 2002-07-17
JP2003504367A (ja) 2003-02-04
RU2241709C2 (ru) 2004-12-10
BR0012327A (pt) 2002-07-02
WO2001004116A2 (en) 2001-01-18
HUP0202249A2 (hu) 2002-12-28
US6809107B1 (en) 2004-10-26
PL352432A1 (en) 2003-08-25
HUP0202249A3 (en) 2003-01-28
IL147505A0 (en) 2002-08-14
CA2379149A1 (en) 2001-01-18
KR20020027486A (ko) 2002-04-13
TW589311B (en) 2004-06-01
WO2001004116A3 (en) 2001-08-23
MXPA02000330A (es) 2004-05-21
AU5485500A (en) 2001-01-30
CN1382140A (zh) 2002-11-27
AU781235B2 (en) 2005-05-12
EP1202990A2 (en) 2002-05-08
IL147505A (en) 2006-07-05

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