AR029150A1 - Un derivado de piperidina, su empleo, un procedimiento para prepararlo y una composicin farmaceutica que lo comprende. - Google Patents
Un derivado de piperidina, su empleo, un procedimiento para prepararlo y una composicin farmaceutica que lo comprende.Info
- Publication number
- AR029150A1 AR029150A1 ARP990105788A ARP990105788A AR029150A1 AR 029150 A1 AR029150 A1 AR 029150A1 AR P990105788 A ARP990105788 A AR P990105788A AR P990105788 A ARP990105788 A AR P990105788A AR 029150 A1 AR029150 A1 AR 029150A1
- Authority
- AR
- Argentina
- Prior art keywords
- heteroaryl
- alkyl
- aralkyl
- aryl
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- NDZYPHLNJZSQJY-QNWVGRARSA-N 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(1r,2s)-2-[[(3s)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea Chemical compound CC1=C(C(=O)C)SC(NC(=O)N[C@H]2[C@@H](CCCC2)CN2C[C@H](CC=3C=CC(F)=CC=3)CCC2)=N1 NDZYPHLNJZSQJY-QNWVGRARSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- -1 amino, amino Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un derivado de piperidina seleccionado entre los compuestos de formula (1) en donde Ar1 y Ar2 son independientemente entre sí, arilo o heteroarilo; R y R1 son independientemente entre sí, halogeno o alquilo; R2 es un grupo alquilo C3-6, heteroarilo, arilo, aralquilo, heteroarilo, heteroarilalquilo, heterociclilalquilo, - (alquileno) ûC(O)-Z, en donde Z es alquilo, haloalquilo, alcoxilo, haloalquiloxilo, hidroxilo, amino, amino mono o disustituido, arilo, aralquilo, ariloxilo, aralquiloxilo, heterarilo, heteroariloxilo o heteroaralquiloxilo; X es un grupo seleccionado de: (a) ûC(O)N(R3)-; (b) ûN(R4)C(O)N(R3)-; (c) ûN(R4)C(S)N(R3)-; (d) ûSO2N(R3)-; o (e) ûN(R4)SO2N(R3)-; en donde: R3 y R4 son independientemente entre sí, hidrogeno, alquilo, aralquilo, heteroaralquilo, heterocicloalquilo, heteroalquilo o û(alquileno)-C(O)-Z en donde Z es alquilo, haloalquilo, alcoxilo, haloalquiloxilo, hidroxilo, amino, amino mono o disustituido, arilo, aralquilo, ariloxilo, aralquiloxilo, heteroarilo, heteroariloxilo o heteroaralquiloxilo; e Y es un enlace o alquileno C1-3 y profármacos isomeros individuales, mezclas de isomeros, y sales farmacéuticamente aceptables de los mismos; el empleo del derivado de formula (1) para la preparacion de un medicamento que comprende como ingrediente activo el derivado de formula (1), para el tratamiento de una enfermedad que puede tratarse mediante la administracion de un antagonista de CCR-3, específicamente cuando esta enfermedad es el asma; un procedimiento para preparar el derivado de formula (1); y una composicion farmacéutica que lo comprende.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10879698P | 1998-11-17 | 1998-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029150A1 true AR029150A1 (es) | 2003-06-18 |
Family
ID=22324087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105788A AR029150A1 (es) | 1998-11-17 | 1999-11-15 | Un derivado de piperidina, su empleo, un procedimiento para prepararlo y una composicin farmaceutica que lo comprende. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6140344A (es) |
| EP (1) | EP1131291B1 (es) |
| JP (1) | JP3475177B2 (es) |
| KR (1) | KR20010087395A (es) |
| CN (1) | CN1163484C (es) |
| AR (1) | AR029150A1 (es) |
| AT (1) | ATE280157T1 (es) |
| AU (1) | AU757747B2 (es) |
| BR (1) | BR9915403A (es) |
| CA (1) | CA2350722A1 (es) |
| CO (1) | CO5150176A1 (es) |
| DE (2) | DE69921351T2 (es) |
| ES (2) | ES2230899T3 (es) |
| FR (1) | FR2785902B1 (es) |
| GB (1) | GB2343891B (es) |
| IT (1) | IT1307062B1 (es) |
| PE (1) | PE20001303A1 (es) |
| PT (1) | PT1131291E (es) |
| TR (1) | TR200101155T2 (es) |
| UY (1) | UY25804A1 (es) |
| WO (1) | WO2000029377A1 (es) |
| ZA (1) | ZA200103249B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1140086A4 (en) * | 1998-12-18 | 2002-04-03 | Du Pont Pharm Co | N-UREIDOALKYL-PIPERIDINES FOR USE AS MODULATORS OF THE ACTIVITY OF CHIMIOKIN RECEPTORS |
| CA2347909A1 (en) * | 1998-12-18 | 2000-06-22 | Joseph B. Santella, Iii | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| AU2482100A (en) * | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| KR20010108394A (ko) | 1999-03-26 | 2001-12-07 | 다비드 에 질레스 | 신규 화합물 |
| GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
| TWI227231B (en) | 2000-07-12 | 2005-02-01 | Novartis Ag | 4-benzoyl-piperidine derivatives for treating conditions mediated by CCR-3 |
| GB0021670D0 (en) | 2000-09-04 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| AU2001290143A1 (en) | 2000-09-29 | 2002-04-08 | Glaxo Group Limited | Morpholin-acetamide derivatives for the treatment of inflammatory diseases |
| FR2821356A1 (fr) * | 2001-02-23 | 2002-08-30 | Cerep | Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations |
| GB0114699D0 (en) | 2001-06-15 | 2001-08-08 | Novartis Ag | Organic compounds |
| GB0117899D0 (en) | 2001-07-23 | 2001-09-12 | Astrazeneca Ab | Chemical compounds |
| SE0102809D0 (sv) * | 2001-08-22 | 2001-08-22 | Astrazeneca Ab | Novel compounds |
| TW200303304A (en) * | 2002-02-18 | 2003-09-01 | Astrazeneca Ab | Chemical compounds |
| BRPI0407913A (pt) | 2003-02-27 | 2006-03-01 | Hoffmann La Roche | antagonistas receptores de ccr-3 |
| EP1604981A4 (en) | 2003-03-14 | 2008-12-24 | Ono Pharmaceutical Co | NITROGENIC HETEROCYCLIC DERIVATIVES AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE |
| JP4710606B2 (ja) | 2003-04-18 | 2011-06-29 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| CA2543419A1 (en) * | 2003-10-24 | 2005-05-06 | Leyi Gong | Ccr3 receptor antagonists |
| SE0400208D0 (sv) | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
| PE20060598A1 (es) | 2004-09-13 | 2006-08-21 | Ono Pharmaceutical Co | Derivado heterociclo conteniendo nitrogeno como antagonista de quimiocina ccr5 |
| US20110052612A1 (en) | 2005-05-31 | 2011-03-03 | Ono Pharmaceutical Co., Ltd. | Spiropiperidine compound and medicinal use thereof |
| ES2427989T3 (es) | 2005-10-28 | 2013-11-05 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| PL1961744T3 (pl) | 2005-11-18 | 2013-09-30 | Ono Pharmaceutical Co | Związek zawierający grupę zasadową oraz jego zastosowanie |
| RU2008140144A (ru) | 2006-03-10 | 2010-04-20 | Оно Фармасьютикал Ко., Лтд. (Jp) | Азотосодержащее гетероциклическое производное и фармацевтическое средство, включающее такое производное в качестве активного ингредиента |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| WO2008016006A1 (en) | 2006-07-31 | 2008-02-07 | Ono Pharmaceutical Co., Ltd. | Compound having cyclic group bound thereto through spiro binding and use thereof |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| WO2013080811A1 (ja) | 2011-11-28 | 2013-06-06 | 国立大学法人名古屋大学 | リンパ球性漏斗下垂体後葉炎のバイオマーカー及びその用途 |
| ES2908668T3 (es) | 2017-09-13 | 2022-05-03 | Syngenta Participations Ag | Derivados de quinolina (tio)carboxamida microbiocidas |
| EP3681285B1 (en) * | 2017-09-13 | 2021-11-17 | Syngenta Participations AG | Microbiocidal quinoline (thio)carboxamide derivatives |
| WO2019053016A1 (en) * | 2017-09-13 | 2019-03-21 | Syngenta Participations Ag | MICROBIOCIDE DERIVATIVES OF QUINOLINE (THIO) CARBOXAMIDE |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK159420C (da) * | 1983-03-09 | 1991-03-11 | Ciba Geigy Ag | N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater |
| FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
| JPH041128A (ja) * | 1990-03-07 | 1992-01-06 | Ajinomoto Co Inc | 抗不整脈薬 |
| US5143923B1 (en) * | 1991-04-29 | 1993-11-02 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzoisothiazole-and benzisoxazole-3-carboxamides |
| DK60893D0 (da) * | 1993-05-26 | 1993-05-26 | Novo Nordisk As | Piperidinderivater, deres fremstilling og anvendelse |
| WO1995000481A1 (en) * | 1993-06-23 | 1995-01-05 | Merrell Dow Pharmaceuticals Inc. | Piperidin-1-yl-2,2-dialkylpropanonearylsulfonamide derivatives |
| EP0661266A1 (en) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Substituted cyclic amine compounds as 5HT2 antagonists |
| US5728835A (en) * | 1993-12-27 | 1998-03-17 | Toa Eiyo, Ltd. | Substituted cyclic amine compound, production process thereof and pharmaceutical composition for circulatory organ use containing the same |
| JPH09249566A (ja) * | 1996-03-19 | 1997-09-22 | Takeda Chem Ind Ltd | ピペリジン化合物含有ケモカイン受容体拮抗剤 |
| DE19624659A1 (de) * | 1996-06-20 | 1998-01-08 | Klinge Co Chem Pharm Fab | Neue Pyridylalken- und Pyridylalkinsäureamide |
| EP0912505A4 (en) * | 1996-06-27 | 2001-10-24 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| US6323206B1 (en) * | 1996-07-12 | 2001-11-27 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| AU8576098A (en) * | 1997-07-25 | 1999-02-16 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
| IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| US6433165B1 (en) * | 1998-01-21 | 2002-08-13 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
-
1999
- 1999-11-08 PT PT99953974T patent/PT1131291E/pt unknown
- 1999-11-08 EP EP99953974A patent/EP1131291B1/en not_active Expired - Lifetime
- 1999-11-08 CN CNB998131784A patent/CN1163484C/zh not_active Expired - Fee Related
- 1999-11-08 ES ES99953974T patent/ES2230899T3/es not_active Expired - Lifetime
- 1999-11-08 JP JP2000582364A patent/JP3475177B2/ja not_active Expired - Fee Related
- 1999-11-08 KR KR1020017006070A patent/KR20010087395A/ko not_active Application Discontinuation
- 1999-11-08 DE DE69921351T patent/DE69921351T2/de not_active Expired - Fee Related
- 1999-11-08 CA CA002350722A patent/CA2350722A1/en not_active Abandoned
- 1999-11-08 BR BR9915403-0A patent/BR9915403A/pt not_active IP Right Cessation
- 1999-11-08 AT AT99953974T patent/ATE280157T1/de not_active IP Right Cessation
- 1999-11-08 AU AU10459/00A patent/AU757747B2/en not_active Ceased
- 1999-11-08 WO PCT/EP1999/008548 patent/WO2000029377A1/en not_active Application Discontinuation
- 1999-11-08 TR TR2001/01155T patent/TR200101155T2/xx unknown
- 1999-11-12 PE PE1999001151A patent/PE20001303A1/es not_active Application Discontinuation
- 1999-11-15 GB GB9926969A patent/GB2343891B/en not_active Expired - Fee Related
- 1999-11-15 FR FR9914276A patent/FR2785902B1/fr not_active Expired - Fee Related
- 1999-11-15 AR ARP990105788A patent/AR029150A1/es unknown
- 1999-11-16 IT IT1999TO000990A patent/IT1307062B1/it active
- 1999-11-16 UY UY25804A patent/UY25804A1/es unknown
- 1999-11-16 CO CO99071853A patent/CO5150176A1/es unknown
- 1999-11-16 ES ES009902495A patent/ES2160525B1/es not_active Expired - Fee Related
- 1999-11-17 DE DE19955340A patent/DE19955340A1/de not_active Withdrawn
- 1999-11-17 US US09/441,919 patent/US6140344A/en not_active Expired - Fee Related
-
2001
- 2001-04-20 ZA ZA200103249A patent/ZA200103249B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69921351D1 (de) | 2004-11-25 |
| FR2785902A1 (fr) | 2000-05-19 |
| BR9915403A (pt) | 2001-08-14 |
| EP1131291A1 (en) | 2001-09-12 |
| US6140344A (en) | 2000-10-31 |
| AU1045900A (en) | 2000-06-05 |
| ES2160525B1 (es) | 2002-06-16 |
| GB2343891A (en) | 2000-05-24 |
| EP1131291B1 (en) | 2004-10-20 |
| UY25804A1 (es) | 2001-07-31 |
| FR2785902B1 (fr) | 2003-09-26 |
| CN1163484C (zh) | 2004-08-25 |
| ATE280157T1 (de) | 2004-11-15 |
| AU757747B2 (en) | 2003-03-06 |
| JP3475177B2 (ja) | 2003-12-08 |
| DE69921351T2 (de) | 2006-03-09 |
| CN1326441A (zh) | 2001-12-12 |
| TR200101155T2 (tr) | 2001-09-21 |
| GB2343891B (en) | 2001-05-30 |
| DE19955340A1 (de) | 2000-05-31 |
| ES2230899T3 (es) | 2005-05-01 |
| IT1307062B1 (it) | 2001-10-23 |
| JP2002529531A (ja) | 2002-09-10 |
| PE20001303A1 (es) | 2000-11-30 |
| ITTO990990A0 (it) | 1999-11-16 |
| CA2350722A1 (en) | 2000-05-25 |
| GB9926969D0 (en) | 2000-01-12 |
| WO2000029377A1 (en) | 2000-05-25 |
| PT1131291E (pt) | 2005-01-31 |
| ZA200103249B (en) | 2002-07-22 |
| ES2160525A1 (es) | 2001-11-01 |
| CO5150176A1 (es) | 2002-04-29 |
| KR20010087395A (ko) | 2001-09-15 |
| ITTO990990A1 (it) | 2001-05-16 |
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