YU224790A - Aminokarbonil karbamati, sorodni fizostigminu/in postopek za njihovo pripravo in njihova uporaba kot zdravila - Google Patents
Aminokarbonil karbamati, sorodni fizostigminu/in postopek za njihovo pripravo in njihova uporaba kot zdravilaInfo
- Publication number
- YU224790A YU224790A YU224790A YU224790A YU224790A YU 224790 A YU224790 A YU 224790A YU 224790 A YU224790 A YU 224790A YU 224790 A YU224790 A YU 224790A YU 224790 A YU224790 A YU 224790A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- preparation
- physostigmin
- carbamates
- aminocarbonyl
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
AMINOKARBONIL KARBAMATI, SORODNI FIZOSTIGMINU/IN POSTOPEK ZA NJIHOVO PRIPRAVO IN NJIHOVA UPORABA KOT ZDRAVILA, aminokar-bonikarbamati, sorodni fizostigminu, postopek za njihovo pripravo in njihova uporaba kot zdravila. Predloženi izum se nanaša na razne derivate, sorodne fizostigminu, s formulo I kjer je Zvodik, halogen ali nižji alkil; R1nižji alkil, cikloalkil ali aril; in R2nižji alkil ali cikloalkil; njihov 3aS-cis izomer ali 3aR-izomer ali zmes obeh izomerov, vključno racemno zmes, ali njihovo farmacevtsko sprejemljivo kislinsko adicijsko sol, in postopek za njihovo pripravo. Spojine v smislu izuma so koristne za povečanje holinergičnih funkcij in kot analgetiki.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/443,682 US5077289A (en) | 1989-11-30 | 1989-11-30 | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
Publications (1)
Publication Number | Publication Date |
---|---|
YU224790A true YU224790A (sh) | 1993-10-20 |
Family
ID=23761787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU224790A YU224790A (sh) | 1989-11-30 | 1990-11-26 | Aminokarbonil karbamati, sorodni fizostigminu/in postopek za njihovo pripravo in njihova uporaba kot zdravila |
Country Status (23)
Country | Link |
---|---|
US (1) | US5077289A (sh) |
EP (1) | EP0430201B1 (sh) |
JP (1) | JPH0723378B2 (sh) |
KR (1) | KR100215346B1 (sh) |
AT (1) | ATE143020T1 (sh) |
AU (1) | AU626740B2 (sh) |
CA (1) | CA2031079C (sh) |
CZ (1) | CZ280888B6 (sh) |
DE (1) | DE69028605T2 (sh) |
DK (1) | DK0430201T3 (sh) |
ES (1) | ES2094742T3 (sh) |
FI (1) | FI93451C (sh) |
GR (1) | GR3021210T3 (sh) |
HU (1) | HU207321B (sh) |
IE (1) | IE75716B1 (sh) |
IL (1) | IL96498A (sh) |
NO (1) | NO175310C (sh) |
NZ (1) | NZ236248A (sh) |
PL (1) | PL165775B1 (sh) |
PT (1) | PT96030B (sh) |
RU (1) | RU2069664C1 (sh) |
YU (1) | YU224790A (sh) |
ZA (1) | ZA909590B (sh) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
AU634654B2 (en) * | 1990-05-11 | 1993-02-25 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments |
US5173497A (en) * | 1990-05-17 | 1992-12-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs |
US5480651A (en) * | 1992-03-16 | 1996-01-02 | Regents Of The University Of California | Composition and method for treating nicotine craving in smoking cessation |
NZ248180A (en) * | 1992-07-21 | 1995-02-24 | Hoechst Roussel Pharma | Process for the preparation of physostigmine carbamate derivatives |
US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
US20050182044A1 (en) * | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
CA2508585A1 (en) * | 2004-06-01 | 2005-12-01 | Axonyx, Inc. | Transdermal delivery system for treatment of cognitive disorders |
WO2005123068A2 (en) * | 2004-06-08 | 2005-12-29 | Axonyx, Inc. | Methods of dealying alzheimer’s disease progression using a beta-amyloid precursor protein inhibitor and a hmg coa reductase inhibitor |
WO2006004201A1 (ja) * | 2004-07-01 | 2006-01-12 | Eisai R & D Management Co., Ltd. | 神経再生促進剤 |
TWI655179B (zh) * | 2014-02-28 | 2019-04-01 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
US4765985A (en) * | 1985-03-05 | 1988-08-23 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
US4680172A (en) * | 1985-03-05 | 1987-07-14 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
US4900748A (en) * | 1988-03-04 | 1990-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates related to (-)-physostigmine as cholinergic agents |
US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
-
1989
- 1989-11-30 US US07/443,682 patent/US5077289A/en not_active Expired - Fee Related
-
1990
- 1990-11-26 YU YU224790A patent/YU224790A/sh unknown
- 1990-11-28 ES ES90122731T patent/ES2094742T3/es not_active Expired - Lifetime
- 1990-11-28 AT AT90122731T patent/ATE143020T1/de not_active IP Right Cessation
- 1990-11-28 DK DK90122731.4T patent/DK0430201T3/da active
- 1990-11-28 DE DE69028605T patent/DE69028605T2/de not_active Expired - Fee Related
- 1990-11-28 EP EP90122731A patent/EP0430201B1/en not_active Expired - Lifetime
- 1990-11-28 IL IL9649890A patent/IL96498A/en not_active IP Right Cessation
- 1990-11-28 NZ NZ236248A patent/NZ236248A/xx unknown
- 1990-11-28 FI FI905855A patent/FI93451C/fi not_active IP Right Cessation
- 1990-11-29 RU SU904831661A patent/RU2069664C1/ru active
- 1990-11-29 JP JP2326196A patent/JPH0723378B2/ja not_active Expired - Fee Related
- 1990-11-29 CZ CS905948A patent/CZ280888B6/cs not_active IP Right Cessation
- 1990-11-29 IE IE430890A patent/IE75716B1/en not_active IP Right Cessation
- 1990-11-29 AU AU67085/90A patent/AU626740B2/en not_active Ceased
- 1990-11-29 PL PL90288016A patent/PL165775B1/pl unknown
- 1990-11-29 ZA ZA909590A patent/ZA909590B/xx unknown
- 1990-11-29 KR KR1019900019447A patent/KR100215346B1/ko not_active IP Right Cessation
- 1990-11-29 CA CA002031079A patent/CA2031079C/en not_active Expired - Fee Related
- 1990-11-29 PT PT96030A patent/PT96030B/pt not_active IP Right Cessation
- 1990-11-29 NO NO905172A patent/NO175310C/no not_active IP Right Cessation
- 1990-11-30 HU HU908014A patent/HU207321B/hu not_active IP Right Cessation
-
1996
- 1996-09-30 GR GR960402567T patent/GR3021210T3/el unknown
Also Published As
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