PT96030A - Processo para a preparacao de aminocarbonilcarbamatos relacionados com fisoestigmina e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de aminocarbonilcarbamatos relacionados com fisoestigmina e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT96030A PT96030A PT96030A PT9603090A PT96030A PT 96030 A PT96030 A PT 96030A PT 96030 A PT96030 A PT 96030A PT 9603090 A PT9603090 A PT 9603090A PT 96030 A PT96030 A PT 96030A
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- loweralkyl
- finoestigmine
- aminocarbonilcarbamates
- contain
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000006949 cholinergic function Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 abstract 1
- 229960001697 physostigmine Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/443,682 US5077289A (en) | 1989-11-30 | 1989-11-30 | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT96030A true PT96030A (pt) | 1991-09-13 |
| PT96030B PT96030B (pt) | 1998-01-30 |
Family
ID=23761787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96030A PT96030B (pt) | 1989-11-30 | 1990-11-29 | Processo para a preparacao de aminocarbonilcarbamatos relacionados com fisoestigmina e de composicoes farmaceuticas que os contem |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5077289A (pt) |
| EP (1) | EP0430201B1 (pt) |
| JP (1) | JPH0723378B2 (pt) |
| KR (1) | KR100215346B1 (pt) |
| AT (1) | ATE143020T1 (pt) |
| AU (1) | AU626740B2 (pt) |
| CA (1) | CA2031079C (pt) |
| CZ (1) | CZ280888B6 (pt) |
| DE (1) | DE69028605T2 (pt) |
| DK (1) | DK0430201T3 (pt) |
| ES (1) | ES2094742T3 (pt) |
| FI (1) | FI93451C (pt) |
| GR (1) | GR3021210T3 (pt) |
| HU (1) | HU207321B (pt) |
| IE (1) | IE75716B1 (pt) |
| IL (1) | IL96498A (pt) |
| NO (1) | NO175310C (pt) |
| NZ (1) | NZ236248A (pt) |
| PL (1) | PL165775B1 (pt) |
| PT (1) | PT96030B (pt) |
| RU (1) | RU2069664C1 (pt) |
| YU (1) | YU224790A (pt) |
| ZA (1) | ZA909590B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| AU634654B2 (en) * | 1990-05-11 | 1993-02-25 | Hoechst-Roussel Pharmaceuticals Incorporated | Pyrrolo(2,3-b)indole-ketones and analogs, a process for their preparation and their use as medicaments |
| US5173497A (en) * | 1990-05-17 | 1992-12-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Alpha-oxopyrrolo[2,3-B]indole acetic acids, esters, amides and related analogs |
| US5480651A (en) * | 1992-03-16 | 1996-01-02 | Regents Of The University Of California | Composition and method for treating nicotine craving in smoking cessation |
| PH30885A (en) * | 1992-07-21 | 1997-12-23 | Hoechst Roussel Pharma | Preparation of physostigmie carbamate derivatives from physostigmine. |
| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| US5665880A (en) * | 1996-10-31 | 1997-09-09 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseretholes |
| US5677457A (en) * | 1996-12-19 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of preparation of physostigmine carbamate derivatives from eseroline ethers |
| US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
| US20050182044A1 (en) * | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
| CA2508585A1 (en) * | 2004-06-01 | 2005-12-01 | Axonyx, Inc. | Transdermal delivery system for treatment of cognitive disorders |
| US20050272804A1 (en) * | 2004-06-08 | 2005-12-08 | Axonyx, Inc | Methods of delaying Alzheimer's disease progression using a beta-amyloid precursor protein inhibitor and a HMG CoA reductase inhibitor |
| US20080045500A1 (en) * | 2004-07-01 | 2008-02-21 | Eisai R&D Management Co., Ltd. | Nerve Regeneration Stimulator |
| US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
| TWI698415B (zh) * | 2014-02-28 | 2020-07-11 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1199076B (it) * | 1984-03-01 | 1988-12-30 | Consiglio Nazionale Ricerche | Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione |
| US4680172A (en) * | 1985-03-05 | 1987-07-14 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
| US4765985A (en) * | 1985-03-05 | 1988-08-23 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| IT1225462B (it) * | 1987-04-03 | 1990-11-14 | Mediolanum Farmaceutici Srl | Sali organici di derivati della fisostigmina |
| US4900748A (en) * | 1988-03-04 | 1990-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates related to (-)-physostigmine as cholinergic agents |
| US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
-
1989
- 1989-11-30 US US07/443,682 patent/US5077289A/en not_active Expired - Fee Related
-
1990
- 1990-11-26 YU YU224790A patent/YU224790A/sh unknown
- 1990-11-28 DK DK90122731.4T patent/DK0430201T3/da active
- 1990-11-28 ES ES90122731T patent/ES2094742T3/es not_active Expired - Lifetime
- 1990-11-28 IL IL9649890A patent/IL96498A/en not_active IP Right Cessation
- 1990-11-28 NZ NZ236248A patent/NZ236248A/xx unknown
- 1990-11-28 EP EP90122731A patent/EP0430201B1/en not_active Expired - Lifetime
- 1990-11-28 FI FI905855A patent/FI93451C/fi not_active IP Right Cessation
- 1990-11-28 AT AT90122731T patent/ATE143020T1/de not_active IP Right Cessation
- 1990-11-28 DE DE69028605T patent/DE69028605T2/de not_active Expired - Fee Related
- 1990-11-29 KR KR1019900019447A patent/KR100215346B1/ko not_active Expired - Fee Related
- 1990-11-29 JP JP2326196A patent/JPH0723378B2/ja not_active Expired - Fee Related
- 1990-11-29 PL PL90288016A patent/PL165775B1/pl unknown
- 1990-11-29 IE IE430890A patent/IE75716B1/en not_active IP Right Cessation
- 1990-11-29 RU SU904831661A patent/RU2069664C1/ru active
- 1990-11-29 CZ CS905948A patent/CZ280888B6/cs not_active IP Right Cessation
- 1990-11-29 PT PT96030A patent/PT96030B/pt not_active IP Right Cessation
- 1990-11-29 AU AU67085/90A patent/AU626740B2/en not_active Ceased
- 1990-11-29 NO NO905172A patent/NO175310C/no not_active IP Right Cessation
- 1990-11-29 CA CA002031079A patent/CA2031079C/en not_active Expired - Fee Related
- 1990-11-29 ZA ZA909590A patent/ZA909590B/xx unknown
- 1990-11-30 HU HU908014A patent/HU207321B/hu not_active IP Right Cessation
-
1996
- 1996-09-30 GR GR960402567T patent/GR3021210T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910410 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19971028 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20050428 |