ES2182086T3 - Nuevos derivados de peptidil-arginina aldehido. - Google Patents

Nuevos derivados de peptidil-arginina aldehido.

Info

Publication number
ES2182086T3
ES2182086T3 ES97925210T ES97925210T ES2182086T3 ES 2182086 T3 ES2182086 T3 ES 2182086T3 ES 97925210 T ES97925210 T ES 97925210T ES 97925210 T ES97925210 T ES 97925210T ES 2182086 T3 ES2182086 T3 ES 2182086T3
Authority
ES
Spain
Prior art keywords
group
formula
peptidil
aldehido
arginina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97925210T
Other languages
English (en)
Inventor
Sandor Bajusz
Attila Juhasz
Eva Barabas
Andras Feher
Gabriella Szabo
Erzsebet Szell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Institute for Drugs Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Drugs Research Ltd filed Critical Institute for Drugs Research Ltd
Application granted granted Critical
Publication of ES2182086T3 publication Critical patent/ES2182086T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE ALDEHIDO DE PEPTIDIL - ARGININA, DE FORMULA GENERAL (I): Q - D - X AA -PRO - ARG H, DONDE Q REPRESENTA UN GRUPO ACILO DE FORMULA Q'' -O - CO - , DONDE Q'' REPRESENTA UN GRUPO ALQUILO DE 1-3 ATOMOS DE CARBONO, D X AA REPRESENTA UN GRUPO 3 - CICLOBUTIL - D - ALANIL - O 3 CICLO - PENTIL - D - ALANIL -, PRO REPRESENTA UN GRUPO L - PROLIL Y ARG REPRESENTA UN GRUPO L - ARGINIL -, Y SALES DE ADICION ACIDA DE LOS MISMOS, FORMADAS CON UN ACIDO ORGANICO O INORGANICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. DICHOS COMPUESTOS DE FORMULA (I) PRESENTAN VALIOSAS PROPIEDADES TERAPEUTICAS, ESPECIALMENTE ANTICOAGULANTES, JUNTO CON FUNCIONES INHIBIDORAS DE PLAQUETAS Y DEL DESARROLLO DE TROMBOSIS.
ES97925210T 1996-06-05 1997-06-05 Nuevos derivados de peptidil-arginina aldehido. Expired - Lifetime ES2182086T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9601526A HU224315B1 (hu) 1996-06-05 1996-06-05 Véralvadásgátló hatású peptidil-arginin-aldehid-származékok és a vegyületeket tartalmazó gyógyszerkészítmények

Publications (1)

Publication Number Publication Date
ES2182086T3 true ES2182086T3 (es) 2003-03-01

Family

ID=89994025

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97925210T Expired - Lifetime ES2182086T3 (es) 1996-06-05 1997-06-05 Nuevos derivados de peptidil-arginina aldehido.

Country Status (12)

Country Link
US (1) US6235707B1 (es)
EP (1) EP0922054B1 (es)
JP (1) JP3970935B2 (es)
AT (1) ATE222261T1 (es)
AU (1) AU726516B2 (es)
CA (1) CA2256391C (es)
DE (1) DE69714745T2 (es)
DK (1) DK0922054T3 (es)
ES (1) ES2182086T3 (es)
HU (1) HU224315B1 (es)
PT (1) PT922054E (es)
WO (1) WO1997046576A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002506024A (ja) * 1998-03-13 2002-02-26 メルク エンド カムパニー インコーポレーテッド 急性冠動脈虚血症候群および関連状態に対する併用療法および組成物
US6136804A (en) 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
EP1070714B1 (en) 1998-04-10 2004-08-04 Japan Tobacco Inc. Amidine compounds
US7030141B2 (en) 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
EP1482882B1 (en) 2002-02-11 2011-09-14 Gold-T Tech, Inc. Implantable device for preventing thrombus formation
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
KR100874091B1 (ko) * 2007-08-16 2008-12-16 조정용 공기점토 및 이의 제조방법
EP2306178A1 (de) 2009-09-30 2011-04-06 Roche Diagnostics GmbH Verfahren zum Steuern einer photometrischen Messeinheit eines Messgeräts zur Gewinnung und Untersuchung einer Körperflüssigkeitsprobe sowie Messsystem
EP2471945A1 (de) * 2010-12-30 2012-07-04 Siemens Healthcare Diagnostics Products GmbH Verfahren zur Bestimmung von Inhibitoren der Gerinnung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents

Also Published As

Publication number Publication date
ATE222261T1 (de) 2002-08-15
JP2000512278A (ja) 2000-09-19
PT922054E (pt) 2002-12-31
EP0922054B1 (en) 2002-08-14
HU224315B1 (hu) 2005-07-28
AU726516B2 (en) 2000-11-09
HU9601526D0 (en) 1996-08-28
JP3970935B2 (ja) 2007-09-05
DE69714745T2 (de) 2003-04-24
US6235707B1 (en) 2001-05-22
AU3043697A (en) 1998-01-05
DK0922054T3 (da) 2002-12-09
CA2256391C (en) 2009-11-24
WO1997046576A1 (en) 1997-12-11
EP0922054A1 (en) 1999-06-16
DE69714745D1 (de) 2002-09-19
HUP9601526A2 (hu) 1998-10-28
CA2256391A1 (en) 1997-12-11
HUP9601526A3 (en) 1999-03-01

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