CO4900068A1 - Piperazina di - n - sustituidas y piperidinas 1,4 -di- sustituidas utiles como antagonistas muscarinicos - Google Patents
Piperazina di - n - sustituidas y piperidinas 1,4 -di- sustituidas utiles como antagonistas muscarinicosInfo
- Publication number
- CO4900068A1 CO4900068A1 CO97045104A CO97045104A CO4900068A1 CO 4900068 A1 CO4900068 A1 CO 4900068A1 CO 97045104 A CO97045104 A CO 97045104A CO 97045104 A CO97045104 A CO 97045104A CO 4900068 A1 CO4900068 A1 CO 4900068A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- piperazine
- muscarinic antagonists
- piperidines
- useful
- Prior art date
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
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- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
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- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- Hydrogenated Pyridines (AREA)
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Abstract
Compuestos de piperazina di-N-sustituida o piperidina1,4-di-sustituida de acuerdo con la fórmula I (incluyendo todos los isómeros, sales, ésteres y solvatos) en donde R, R1 , R2 , R3 , R4 , R21 , R27 , R28 , X, Y y Z son como se definen en la presente, antagonistas muscarínicos útiles para el tratamiento de trastornos cognitivos como ser la enfermedad de Alzheimer. También se describen composiciones farmacéuticas y métodos de preparación. Se describen además combinaciones de compuestos sinérgicas de la fórmula que figura anteriormente con inhibidores de acetilcolinesterasa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US08/700,628 US5889006A (en) | 1995-02-23 | 1996-08-08 | Muscarinic antagonists |
Publications (1)
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CO4900068A1 true CO4900068A1 (es) | 2000-03-27 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CO97045104A CO4900068A1 (es) | 1996-08-08 | 1997-08-06 | Piperazina di - n - sustituidas y piperidinas 1,4 -di- sustituidas utiles como antagonistas muscarinicos |
Country Status (26)
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US (2) | US5889006A (es) |
EP (1) | EP0938483B1 (es) |
JP (1) | JP3748894B2 (es) |
KR (1) | KR100344332B1 (es) |
CN (1) | CN1084743C (es) |
AR (1) | AR008285A1 (es) |
AT (1) | ATE233260T1 (es) |
AU (1) | AU724001B2 (es) |
BR (1) | BR9711119A (es) |
CA (1) | CA2261725C (es) |
CO (1) | CO4900068A1 (es) |
CZ (1) | CZ36699A3 (es) |
DE (1) | DE69719354T2 (es) |
ES (1) | ES2193391T3 (es) |
HK (1) | HK1018776A1 (es) |
HU (1) | HUP9902827A3 (es) |
ID (1) | ID18003A (es) |
IL (1) | IL128409A0 (es) |
NO (1) | NO990551L (es) |
NZ (1) | NZ333801A (es) |
PE (1) | PE99598A1 (es) |
PL (1) | PL331534A1 (es) |
SK (1) | SK15599A3 (es) |
TR (1) | TR199900255T2 (es) |
WO (1) | WO1998005292A2 (es) |
ZA (1) | ZA977011B (es) |
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1997
- 1997-08-06 BR BR9711119-8A patent/BR9711119A/pt unknown
- 1997-08-06 SK SK155-99A patent/SK15599A3/sk unknown
- 1997-08-06 ES ES97936296T patent/ES2193391T3/es not_active Expired - Lifetime
- 1997-08-06 AU AU38999/97A patent/AU724001B2/en not_active Ceased
- 1997-08-06 CN CN97198479A patent/CN1084743C/zh not_active Expired - Fee Related
- 1997-08-06 AR ARP970103584A patent/AR008285A1/es unknown
- 1997-08-06 DE DE69719354T patent/DE69719354T2/de not_active Expired - Fee Related
- 1997-08-06 JP JP50803898A patent/JP3748894B2/ja not_active Expired - Fee Related
- 1997-08-06 AT AT97936296T patent/ATE233260T1/de not_active IP Right Cessation
- 1997-08-06 WO PCT/US1997/013383 patent/WO1998005292A2/en not_active Application Discontinuation
- 1997-08-06 KR KR1019997001175A patent/KR100344332B1/ko not_active IP Right Cessation
- 1997-08-06 NZ NZ333801A patent/NZ333801A/xx unknown
- 1997-08-06 PE PE1997000687A patent/PE99598A1/es not_active Application Discontinuation
- 1997-08-06 EP EP97936296A patent/EP0938483B1/en not_active Expired - Lifetime
- 1997-08-06 CO CO97045104A patent/CO4900068A1/es unknown
- 1997-08-06 ZA ZA9707011A patent/ZA977011B/xx unknown
- 1997-08-06 TR TR1999/00255T patent/TR199900255T2/xx unknown
- 1997-08-06 CA CA002261725A patent/CA2261725C/en not_active Expired - Fee Related
- 1997-08-06 CZ CZ99366A patent/CZ36699A3/cs unknown
- 1997-08-06 IL IL12840997A patent/IL128409A0/xx unknown
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1999
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- 1999-09-02 HK HK99103789A patent/HK1018776A1/xx not_active IP Right Cessation
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