GT199600092A - Procedimientos e intermedios para preparar 1-bencil-4-(5,6-dimetoxi-1-indanon)-2-il)metilpiperidina. - Google Patents
Procedimientos e intermedios para preparar 1-bencil-4-(5,6-dimetoxi-1-indanon)-2-il)metilpiperidina.Info
- Publication number
- GT199600092A GT199600092A GT199600092A GT199600092A GT199600092A GT 199600092 A GT199600092 A GT 199600092A GT 199600092 A GT199600092 A GT 199600092A GT 199600092 A GT199600092 A GT 199600092A GT 199600092 A GT199600092 A GT 199600092A
- Authority
- GT
- Guatemala
- Prior art keywords
- methylpiperidine
- dimetoxi
- bencil
- indanon
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
UN COMPUESTO DE FORMULA III, EN LA QUE R1 ES R2 O(C=0)O R3 (C=O), R2 ES ALQUILO DE C1C4 Y R3 ES ALQUILO DE C1C4 O FENILO OPCIONALMENTE SUSTITUIDO CON UNO A TRES SUSTITUYENTES SELECCIONADOS INDEPENDIENTEMENTE ENTRE ALQUILO DE C1C4, ALCOXI DE C1C4, HALO O TRIFLUOROMETILO. LA 1BENCIL4[(5,6DIMETOXI1INDANON)2IL]METILPIPERIDINA ES EFICAZ PARA EL TRATAMIENTO, PREVENCION, REMISION Y MEJORIA DE DIVERSOS TIPOS DE DEMENCIA SENIL, EN PARTICULAR LA DEMENCIA SENIL DEL TIPO ALZHEIMER; LA ENFERMEDAD CEREBROVASCULAR QUE ACOMPAÑA A LA APOPLEJIA CEREBRAL Y OTRAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US875395P | 1995-12-15 | 1995-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT199600092A true GT199600092A (es) | 1998-05-12 |
Family
ID=21733469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT199600092A GT199600092A (es) | 1995-12-15 | 1996-11-18 | Procedimientos e intermedios para preparar 1-bencil-4-(5,6-dimetoxi-1-indanon)-2-il)metilpiperidina. |
Country Status (33)
Country | Link |
---|---|
EP (1) | EP0883607A1 (es) |
JP (1) | JP3066083B2 (es) |
KR (1) | KR20000064387A (es) |
AP (1) | AP708A (es) |
AR (1) | AR004368A1 (es) |
AU (1) | AU716462B2 (es) |
BG (1) | BG102525A (es) |
BR (1) | BR9612018A (es) |
CA (1) | CA2237647A1 (es) |
CO (1) | CO4750831A1 (es) |
CZ (1) | CZ180898A3 (es) |
DZ (1) | DZ2141A1 (es) |
GT (1) | GT199600092A (es) |
HN (1) | HN1996000065A (es) |
HR (1) | HRP960592A2 (es) |
HU (1) | HUP9904275A3 (es) |
IL (3) | IL136421A0 (es) |
IS (1) | IS4752A (es) |
MA (1) | MA24032A1 (es) |
NO (1) | NO982712D0 (es) |
NZ (1) | NZ318843A (es) |
OA (1) | OA10694A (es) |
PE (1) | PE25698A1 (es) |
PL (1) | PL197306B1 (es) |
RO (1) | RO121382B1 (es) |
RU (1) | RU2160731C2 (es) |
SK (1) | SK75498A3 (es) |
TN (1) | TNSN96153A1 (es) |
TW (1) | TW414787B (es) |
UY (1) | UY24401A1 (es) |
WO (1) | WO1997022584A1 (es) |
YU (1) | YU49486B (es) |
ZA (1) | ZA9610533B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2316360C (en) | 1998-01-16 | 2007-09-18 | Eisai Co., Ltd. | Process for production of donepezil derivative |
IL125809A (en) | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
IL150982A (en) | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for making Donafzil |
IL151253A0 (en) * | 2002-08-14 | 2003-04-10 | Finetech Lab Ltd | Process for production of highly pure donepezil hydrochloride |
US6953856B2 (en) | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
US20070129549A1 (en) * | 2003-03-21 | 2007-06-07 | Yatendra Kumar | Stable lamotrigine pharmaceutical compositions and processes for their preparation |
WO2004099142A1 (en) * | 2003-05-05 | 2004-11-18 | Ranbaxy Laboratories Limited | Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs |
EP1654230A1 (en) | 2003-07-01 | 2006-05-10 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
CN1280273C (zh) | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | 合成多奈哌齐及其衍生物的方法 |
AU2005288521A1 (en) | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
CN100436416C (zh) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | 盐酸多奈哌齐合成工艺 |
GB0515803D0 (en) * | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
AR057910A1 (es) | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar donepezilo |
ES2354737T3 (es) * | 2006-01-04 | 2011-03-17 | Cipla Limited | Procedimiento y producto intermedio para la preparación de donepezylo. |
WO2008073452A1 (en) * | 2006-12-11 | 2008-06-19 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors |
WO2013078608A1 (en) * | 2011-11-29 | 2013-06-06 | Ziqiang Gu | Donepezil pamoate and methods of making and using the same |
WO2015022418A1 (en) | 2013-08-16 | 2015-02-19 | Takeda Gmbh | Treatment of cognitive impairment with pde4 inhibitor |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
FR2642069B1 (fr) * | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
DE4439822A1 (de) * | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
-
1996
- 1996-10-11 EP EP96931937A patent/EP0883607A1/en not_active Withdrawn
- 1996-10-11 IL IL13642196A patent/IL136421A0/xx unknown
- 1996-10-11 AU AU70925/96A patent/AU716462B2/en not_active Ceased
- 1996-10-11 WO PCT/IB1996/001076 patent/WO1997022584A1/en not_active Application Discontinuation
- 1996-10-11 JP JP9522607A patent/JP3066083B2/ja not_active Expired - Lifetime
- 1996-10-11 RO RO98-01070A patent/RO121382B1/ro unknown
- 1996-10-11 CZ CZ981808A patent/CZ180898A3/cs unknown
- 1996-10-11 NZ NZ318843A patent/NZ318843A/xx unknown
- 1996-10-11 IL IL13642096A patent/IL136420A0/xx unknown
- 1996-10-11 SK SK754-98A patent/SK75498A3/sk unknown
- 1996-10-11 IL IL12445296A patent/IL124452A0/xx unknown
- 1996-10-11 HU HU9904275A patent/HUP9904275A3/hu unknown
- 1996-10-11 PL PL327512A patent/PL197306B1/pl not_active IP Right Cessation
- 1996-10-11 CA CA002237647A patent/CA2237647A1/en not_active Abandoned
- 1996-10-11 BR BR9612018A patent/BR9612018A/pt not_active Application Discontinuation
- 1996-10-11 KR KR1019980704423A patent/KR20000064387A/ko not_active Application Discontinuation
- 1996-10-11 RU RU98111204/04A patent/RU2160731C2/ru not_active IP Right Cessation
- 1996-10-14 TW TW085112515A patent/TW414787B/zh not_active IP Right Cessation
- 1996-10-15 HN HN1996000065A patent/HN1996000065A/es unknown
- 1996-11-18 GT GT199600092A patent/GT199600092A/es unknown
- 1996-12-09 PE PE1996000883A patent/PE25698A1/es not_active Application Discontinuation
- 1996-12-10 AR ARP960105577A patent/AR004368A1/es unknown
- 1996-12-11 YU YU66096A patent/YU49486B/sh unknown
- 1996-12-11 TN TNTNSN96153A patent/TNSN96153A1/fr unknown
- 1996-12-11 DZ DZ960186A patent/DZ2141A1/fr active
- 1996-12-11 MA MA24424A patent/MA24032A1/fr unknown
- 1996-12-12 CO CO96065334A patent/CO4750831A1/es unknown
- 1996-12-12 UY UY24401A patent/UY24401A1/es not_active IP Right Cessation
- 1996-12-12 AP APAP/P/1996/000892A patent/AP708A/en active
- 1996-12-13 HR HR60/008,753A patent/HRP960592A2/xx not_active Application Discontinuation
- 1996-12-13 ZA ZA9610533A patent/ZA9610533B/xx unknown
-
1998
- 1998-05-22 IS IS4752A patent/IS4752A/is unknown
- 1998-06-05 OA OA9800076A patent/OA10694A/en unknown
- 1998-06-09 BG BG102525A patent/BG102525A/xx unknown
- 1998-06-12 NO NO982712A patent/NO982712D0/no not_active Application Discontinuation
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