UY27842A1 - Fluorobenzamidas - Google Patents
FluorobenzamidasInfo
- Publication number
- UY27842A1 UY27842A1 UY27842A UY27842A UY27842A1 UY 27842 A1 UY27842 A1 UY 27842A1 UY 27842 A UY27842 A UY 27842A UY 27842 A UY27842 A UY 27842A UY 27842 A1 UY27842 A1 UY 27842A1
- Authority
- UY
- Uruguay
- Prior art keywords
- general formula
- fluorobenzamids
- alzheimer
- inhibitors
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/69—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/66—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/50—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención se refiere a derivados fluorobenzamida de la fórmula general. Los compuestos de fórmula general I son inhibidores selectivos monoamino oxidasa B y por lo tanto estos son adecuados para el tratamiento de la Enfermedad de Alzheimer o demencia senil.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02012484 | 2002-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY27842A1 true UY27842A1 (es) | 2003-12-31 |
Family
ID=29724375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY27842A UY27842A1 (es) | 2002-06-12 | 2003-06-10 | Fluorobenzamidas |
Country Status (20)
Country | Link |
---|---|
US (1) | US6951884B2 (es) |
EP (1) | EP1515926B1 (es) |
JP (1) | JP4181540B2 (es) |
KR (1) | KR100641963B1 (es) |
CN (1) | CN1274669C (es) |
AR (1) | AR040253A1 (es) |
AT (1) | ATE427928T1 (es) |
AU (1) | AU2003236719B2 (es) |
BR (1) | BR0311719A (es) |
CA (1) | CA2489247A1 (es) |
DE (1) | DE60327074D1 (es) |
ES (1) | ES2322254T3 (es) |
MX (1) | MXPA04012511A (es) |
PA (1) | PA8575001A1 (es) |
PE (1) | PE20040558A1 (es) |
PL (1) | PL374545A1 (es) |
RU (1) | RU2314289C2 (es) |
TW (1) | TW200406201A (es) |
UY (1) | UY27842A1 (es) |
WO (1) | WO2003106380A2 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6979750B1 (en) | 2003-04-18 | 2005-12-27 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
US7321065B2 (en) | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
JP3997255B2 (ja) * | 2004-02-13 | 2007-10-24 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | アンドロゲンレセプターモジュレーター |
BRPI0513020A (pt) * | 2004-07-08 | 2008-04-22 | Warner Lambert Co | moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação |
UA90708C2 (ru) | 2005-02-25 | 2010-05-25 | Ф. Хоффманн-Ля Рош Аг | Таблетки с улучшенной дисперсностью лекарственного вещества |
WO2006127133A2 (en) | 2005-04-01 | 2006-11-30 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
WO2007008963A1 (en) * | 2005-07-13 | 2007-01-18 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
US20090170886A1 (en) * | 2005-08-08 | 2009-07-02 | Pfizer Inc | Androgen modulators |
US8372885B2 (en) * | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
CN102816082B (zh) * | 2010-01-29 | 2015-03-11 | 浙江大学 | 苯甲酰胺类衍生物及制备方法和应用 |
TWI518062B (zh) * | 2011-12-26 | 2016-01-21 | 迪愛生股份有限公司 | 具有2-氟苯基氧基甲烷構造之化合物 |
KR101613602B1 (ko) | 2013-07-25 | 2016-04-19 | 디아이씨 가부시끼가이샤 | 2,6-디플루오로페닐에테르 구조를 갖는 액정성 화합물 및 그 액정 조성물 |
JP5776864B1 (ja) | 2013-08-30 | 2015-09-09 | Dic株式会社 | ネマチック液晶組成物 |
US9573923B2 (en) | 2013-10-03 | 2017-02-21 | Dic Corporation | Liquid crystal compound having 2, 6-difluorophenylether structure, and liquid crystal composition containing the same |
CN106459765B (zh) | 2014-07-31 | 2018-03-09 | Dic株式会社 | 向列型液晶组合物 |
CN106459767B (zh) | 2014-07-31 | 2019-04-19 | Dic株式会社 | 向列型液晶组合物 |
CN108912029B (zh) * | 2017-08-25 | 2021-10-01 | 广东东阳光药业有限公司 | 含氮杂环酰胺衍生物及其用途 |
CN110483324A (zh) * | 2019-09-10 | 2019-11-22 | 深圳振强生物技术有限公司 | 沙芬酰胺杂质的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1332151C (en) * | 1988-01-28 | 1994-09-27 | Roman Amrein | Use of a benzamide to treat cognitive disorder |
TW498067B (en) * | 1996-07-19 | 2002-08-11 | Hoffmann La Roche | 4-hydroxy-piperidine derivatives |
-
2003
- 2003-06-06 US US10/456,641 patent/US6951884B2/en not_active Expired - Fee Related
- 2003-06-07 CN CNB038136694A patent/CN1274669C/zh not_active Expired - Fee Related
- 2003-06-07 ES ES03735578T patent/ES2322254T3/es not_active Expired - Lifetime
- 2003-06-07 DE DE60327074T patent/DE60327074D1/de not_active Expired - Lifetime
- 2003-06-07 PL PL03374545A patent/PL374545A1/xx not_active Application Discontinuation
- 2003-06-07 KR KR1020047020087A patent/KR100641963B1/ko not_active IP Right Cessation
- 2003-06-07 CA CA002489247A patent/CA2489247A1/en not_active Abandoned
- 2003-06-07 JP JP2004513216A patent/JP4181540B2/ja not_active Expired - Fee Related
- 2003-06-07 RU RU2005100755/04A patent/RU2314289C2/ru not_active IP Right Cessation
- 2003-06-07 EP EP03735578A patent/EP1515926B1/en not_active Expired - Lifetime
- 2003-06-07 MX MXPA04012511A patent/MXPA04012511A/es active IP Right Grant
- 2003-06-07 WO PCT/EP2003/006008 patent/WO2003106380A2/en active Search and Examination
- 2003-06-07 BR BR0311719-7A patent/BR0311719A/pt not_active IP Right Cessation
- 2003-06-07 AT AT03735578T patent/ATE427928T1/de not_active IP Right Cessation
- 2003-06-07 AU AU2003236719A patent/AU2003236719B2/en not_active Ceased
- 2003-06-09 PA PA20038575001A patent/PA8575001A1/es unknown
- 2003-06-10 AR ARP030102056A patent/AR040253A1/es not_active Application Discontinuation
- 2003-06-10 PE PE2003000577A patent/PE20040558A1/es not_active Application Discontinuation
- 2003-06-10 TW TW092115681A patent/TW200406201A/zh unknown
- 2003-06-10 UY UY27842A patent/UY27842A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2003106380A2 (en) | 2003-12-24 |
US6951884B2 (en) | 2005-10-04 |
TW200406201A (en) | 2004-05-01 |
KR100641963B1 (ko) | 2006-11-06 |
JP2005529176A (ja) | 2005-09-29 |
PE20040558A1 (es) | 2004-09-09 |
EP1515926A2 (en) | 2005-03-23 |
CA2489247A1 (en) | 2003-12-24 |
EP1515926B1 (en) | 2009-04-08 |
ES2322254T3 (es) | 2009-06-18 |
PL374545A1 (en) | 2005-10-31 |
US20030236304A1 (en) | 2003-12-25 |
CN1274669C (zh) | 2006-09-13 |
RU2314289C2 (ru) | 2008-01-10 |
WO2003106380A3 (en) | 2004-03-11 |
CN1659135A (zh) | 2005-08-24 |
ATE427928T1 (de) | 2009-04-15 |
DE60327074D1 (de) | 2009-05-20 |
AU2003236719B2 (en) | 2008-06-05 |
KR20050009743A (ko) | 2005-01-25 |
BR0311719A (pt) | 2005-03-15 |
RU2005100755A (ru) | 2005-08-10 |
PA8575001A1 (es) | 2003-12-30 |
AU2003236719A1 (en) | 2003-12-31 |
AR040253A1 (es) | 2005-03-23 |
JP4181540B2 (ja) | 2008-11-19 |
MXPA04012511A (es) | 2005-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20150525 |