GT200300095A - Derivados de isoquinolina - Google Patents
Derivados de isoquinolinaInfo
- Publication number
- GT200300095A GT200300095A GT200300095A GT200300095A GT200300095A GT 200300095 A GT200300095 A GT 200300095A GT 200300095 A GT200300095 A GT 200300095A GT 200300095 A GT200300095 A GT 200300095A GT 200300095 A GT200300095 A GT 200300095A
- Authority
- GT
- Guatemala
- Prior art keywords
- isoquinoline derivatives
- alzheimer
- disorders
- record
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A DERIVADOS DE ISOQUINOLINA DE FORMULA GENERAL I EN DONDE Z,Y,R1,M, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SON INHIBIDORES SELECTIVOS DE MONOAMINA OXIDASA B POR LO QUE SON DE UTILIDAD EN TRASTORNOS TALES COMO ALZHEIMER Y DEMENCIA SENIL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02009253 | 2002-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT200300095A true GT200300095A (es) | 2004-01-15 |
Family
ID=29265896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT200300095A GT200300095A (es) | 2002-04-26 | 2003-04-24 | Derivados de isoquinolina |
Country Status (31)
Country | Link |
---|---|
US (1) | US6818774B2 (es) |
EP (1) | EP1501804B1 (es) |
JP (1) | JP4322685B2 (es) |
KR (1) | KR100681585B1 (es) |
CN (1) | CN1310890C (es) |
AR (1) | AR039651A1 (es) |
AT (1) | ATE440821T1 (es) |
AU (1) | AU2003227614B2 (es) |
BR (1) | BR0309562A (es) |
CA (1) | CA2483461C (es) |
DE (1) | DE60328978D1 (es) |
DK (1) | DK1501804T3 (es) |
ES (1) | ES2329354T3 (es) |
GT (1) | GT200300095A (es) |
HK (1) | HK1080836A1 (es) |
HR (1) | HRP20040952A2 (es) |
IL (1) | IL164677A0 (es) |
MX (1) | MXPA04010537A (es) |
MY (1) | MY133527A (es) |
NO (1) | NO20044571L (es) |
NZ (1) | NZ535885A (es) |
PA (1) | PA8572001A1 (es) |
PE (1) | PE20040594A1 (es) |
PL (1) | PL373697A1 (es) |
PT (1) | PT1501804E (es) |
RU (1) | RU2318812C2 (es) |
SI (1) | SI1501804T1 (es) |
TW (1) | TWI278451B (es) |
UY (1) | UY27786A1 (es) |
WO (1) | WO2003091219A1 (es) |
ZA (1) | ZA200408281B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1644367B1 (en) * | 2003-05-19 | 2015-10-14 | Novartis AG | Immunosuppressant compounds and compositions |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
CA2524054C (en) * | 2003-05-19 | 2012-04-24 | Irm Llc | Immunosuppressant compounds and compositions |
ES2754221T3 (es) * | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
CN101407471A (zh) | 2003-08-29 | 2009-04-15 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
DE602004017206D1 (de) * | 2003-10-23 | 2008-11-27 | Hoffmann La Roche | Benzazepin-derivate als mao-b-hemmer |
NZ550216A (en) | 2004-03-01 | 2009-08-28 | Actelion Pharmaceuticals Ltd | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
ATE541830T1 (de) | 2004-12-13 | 2012-02-15 | Ono Pharmaceutical Co | Aminocarbonsäurederivat und dessen medizinische verwendung |
JP4934055B2 (ja) * | 2005-01-28 | 2012-05-16 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | イソクロマンおよびその誘導体の製造方法 |
CA2598762A1 (en) | 2005-02-25 | 2006-08-31 | F. Hoffmann-La Roche Ag | Tablets with improved drug substance dispersibility |
EP1963280B1 (en) | 2005-12-22 | 2015-10-28 | Newron Pharmaceuticals S.p.A. | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
EA015256B1 (ru) * | 2006-03-15 | 2011-06-30 | Актелион Фармасьютикалз Лтд. | Производные тетрагидроизохинолина для повышения функции памяти |
DE602007012072D1 (de) | 2006-04-26 | 2011-03-03 | Actelion Pharmaceuticals Ltd | Orantagonisten |
KR101220182B1 (ko) * | 2009-02-25 | 2013-01-11 | 에스케이바이오팜 주식회사 | 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법 |
CN105315204B (zh) * | 2014-07-04 | 2018-02-09 | 中南大学 | 7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途 |
CN105585527B (zh) * | 2015-12-17 | 2018-06-26 | 浙江工业大学 | 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用 |
CN105461626B (zh) * | 2015-12-17 | 2018-05-08 | 浙江工业大学 | 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用 |
CN110461829B (zh) * | 2017-03-27 | 2023-02-28 | 百时美施贵宝公司 | 作为免疫调节剂的取代的异喹啉衍生物 |
CN114591238B (zh) * | 2022-03-25 | 2022-11-15 | 邦恩泰(山东)生物医药科技集团股份有限公司 | 一种异喹啉类药物中间体的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448269B1 (en) * | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
EP0906090A1 (en) | 1996-03-15 | 1999-04-07 | Somerset Pharmaceuticals, Inc. | Method for preventing and treating peripheral neurophathy by administering selegiline |
WO2001034172A2 (en) | 1999-11-05 | 2001-05-17 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
-
2003
- 2003-04-14 PT PT03725018T patent/PT1501804E/pt unknown
- 2003-04-14 BR BR0309562-2A patent/BR0309562A/pt not_active IP Right Cessation
- 2003-04-14 EP EP03725018A patent/EP1501804B1/en not_active Expired - Lifetime
- 2003-04-14 NZ NZ535885A patent/NZ535885A/en not_active IP Right Cessation
- 2003-04-14 RU RU2004134575/04A patent/RU2318812C2/ru not_active IP Right Cessation
- 2003-04-14 DK DK03725018T patent/DK1501804T3/da active
- 2003-04-14 MX MXPA04010537A patent/MXPA04010537A/es active IP Right Grant
- 2003-04-14 KR KR1020047017185A patent/KR100681585B1/ko not_active IP Right Cessation
- 2003-04-14 AT AT03725018T patent/ATE440821T1/de not_active IP Right Cessation
- 2003-04-14 DE DE60328978T patent/DE60328978D1/de not_active Expired - Lifetime
- 2003-04-14 PL PL03373697A patent/PL373697A1/xx unknown
- 2003-04-14 CA CA2483461A patent/CA2483461C/en not_active Expired - Fee Related
- 2003-04-14 JP JP2003587782A patent/JP4322685B2/ja not_active Expired - Fee Related
- 2003-04-14 CN CNB038093766A patent/CN1310890C/zh not_active Expired - Fee Related
- 2003-04-14 SI SI200331658T patent/SI1501804T1/sl unknown
- 2003-04-14 WO PCT/EP2003/003845 patent/WO2003091219A1/en active Application Filing
- 2003-04-14 AU AU2003227614A patent/AU2003227614B2/en not_active Ceased
- 2003-04-14 ES ES03725018T patent/ES2329354T3/es not_active Expired - Lifetime
- 2003-04-16 US US10/417,378 patent/US6818774B2/en not_active Expired - Fee Related
- 2003-04-23 PA PA20038572001A patent/PA8572001A1/es unknown
- 2003-04-23 TW TW092109478A patent/TWI278451B/zh not_active IP Right Cessation
- 2003-04-24 GT GT200300095A patent/GT200300095A/es unknown
- 2003-04-24 AR ARP030101412A patent/AR039651A1/es unknown
- 2003-04-24 PE PE2003000408A patent/PE20040594A1/es not_active Application Discontinuation
- 2003-04-25 MY MYPI20031578A patent/MY133527A/en unknown
- 2003-04-28 UY UY27786A patent/UY27786A1/es not_active Application Discontinuation
-
2004
- 2004-10-12 HR HR20040952A patent/HRP20040952A2/hr not_active Application Discontinuation
- 2004-10-13 ZA ZA200408281A patent/ZA200408281B/xx unknown
- 2004-10-18 IL IL16467704A patent/IL164677A0/xx not_active IP Right Cessation
- 2004-10-22 NO NO20044571A patent/NO20044571L/no not_active Application Discontinuation
-
2006
- 2006-01-13 HK HK06100541A patent/HK1080836A1/xx not_active IP Right Cessation
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