PE20040594A1 - Derivados de isoquinolina - Google Patents
Derivados de isoquinolinaInfo
- Publication number
- PE20040594A1 PE20040594A1 PE2003000408A PE2003000408A PE20040594A1 PE 20040594 A1 PE20040594 A1 PE 20040594A1 PE 2003000408 A PE2003000408 A PE 2003000408A PE 2003000408 A PE2003000408 A PE 2003000408A PE 20040594 A1 PE20040594 A1 PE 20040594A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- isoquinolin
- benzyloxy
- dihydro
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE LA FORMULA I ENTRE OTROS DONDE Y ES C=O O CH2; Z ES C=O O CH2; R1 ES H O UN GRUPO DE FORMULA a, DONDE R3 ES (CH2)n-CO-NR6R7, (CH2)n-COOR8; (CH2)p-OR8; (CH2)n-CN; ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6, (CH2)p-OR8, (CH2)p-SR8 O BENCILO; R6 Y R7 SON H, ALQUILO C1-C6; R8 ES H O ALQUILO C1-C6; m ES 1, 2 O 3; n ES 0, 1 O 2; p ES 1 O 2; R2 ES HALOGENO, HALOGENO-ALQUILO C1-C6, CN, ALCOXILO C1-C6 O HALOGENO-ALCOXILO C1-C6. SON COMPUESTOS PREFERIDOS: 6-(3-FLUORO-BENCILOXI)-3,4-DIHIDRO-2H-ISOQUINOLIN-1-ONA; 2-[6-(3-FLUORO-BENCILOXI)-1-OXO-3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL]-PROPIONTO DE ETILO; ACIDO DE 2-[6-(3-FLUORO-BENCILOXI)-1-OXO-3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL]-PROPIONICO; 2-[6-(3,4-DIFLUORO-BENCILOXI)-1-OXO-3,4-DIHIDRO-1H-ISOQUINOLIN-2-IL]-PROPIONAMIDA ENTRE OTROS. TAMBIEN SE REFIERE AL PROCESO DE SU ELABORACION. LOS DERIVADOS DE ISOQUINOLINA INHIBIDORES DE LA MONOAMINO OXIDASA B Y SON UTILES PARA EL TRATAMIENTO DE ALZHEIMER Y LA DEMENCIA SENIL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02009253 | 2002-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040594A1 true PE20040594A1 (es) | 2004-08-30 |
Family
ID=29265896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000408A PE20040594A1 (es) | 2002-04-26 | 2003-04-24 | Derivados de isoquinolina |
Country Status (31)
Country | Link |
---|---|
US (1) | US6818774B2 (es) |
EP (1) | EP1501804B1 (es) |
JP (1) | JP4322685B2 (es) |
KR (1) | KR100681585B1 (es) |
CN (1) | CN1310890C (es) |
AR (1) | AR039651A1 (es) |
AT (1) | ATE440821T1 (es) |
AU (1) | AU2003227614B2 (es) |
BR (1) | BR0309562A (es) |
CA (1) | CA2483461C (es) |
DE (1) | DE60328978D1 (es) |
DK (1) | DK1501804T3 (es) |
ES (1) | ES2329354T3 (es) |
GT (1) | GT200300095A (es) |
HK (1) | HK1080836A1 (es) |
HR (1) | HRP20040952A2 (es) |
IL (1) | IL164677A0 (es) |
MX (1) | MXPA04010537A (es) |
MY (1) | MY133527A (es) |
NO (1) | NO20044571L (es) |
NZ (1) | NZ535885A (es) |
PA (1) | PA8572001A1 (es) |
PE (1) | PE20040594A1 (es) |
PL (1) | PL373697A1 (es) |
PT (1) | PT1501804E (es) |
RU (1) | RU2318812C2 (es) |
SI (1) | SI1501804T1 (es) |
TW (1) | TWI278451B (es) |
UY (1) | UY27786A1 (es) |
WO (1) | WO2003091219A1 (es) |
ZA (1) | ZA200408281B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
JP4728962B2 (ja) * | 2003-05-19 | 2011-07-20 | アイアールエム・リミテッド・ライアビリティ・カンパニー | 免疫抑制化合物および組成物 |
US7060697B2 (en) * | 2003-05-19 | 2006-06-13 | Irm Llc | Immunosuppressant compounds and compositions |
JP4947406B2 (ja) * | 2003-08-29 | 2012-06-06 | 小野薬品工業株式会社 | S1p受容体結合能を有する化合物およびその医薬用途 |
CN101407471A (zh) | 2003-08-29 | 2009-04-15 | 小野药品工业株式会社 | 能够结合s1p受体的化合物及其药物用途 |
BRPI0415842A (pt) * | 2003-10-23 | 2007-01-02 | Hoffmann La Roche | derivativos de benzapepina como inibidores de mao-b |
AU2005250077B2 (en) | 2004-03-01 | 2011-06-09 | Idorsia Pharmaceuticals Ltd | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
PL1826197T3 (pl) | 2004-12-13 | 2012-06-29 | Ono Pharmaceutical Co | Pochodna kwasu aminokarboksylowego i jej zastosowanie lecznicze |
EP1844033B1 (de) * | 2005-01-28 | 2011-07-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur herstellung von isochroman und derivaten davon |
CA2598762A1 (en) | 2005-02-25 | 2006-08-31 | F. Hoffmann-La Roche Ag | Tablets with improved drug substance dispersibility |
KR101380137B1 (ko) | 2005-12-22 | 2014-04-11 | 뉴론 파마슈티칼즈 에스. 피. 에이. | 칼슘 및/또는 나트륨 채널 조절제로서 2-페닐에틸아미노유도체 |
CA2644010A1 (en) * | 2006-03-15 | 2007-09-20 | Actelion Pharmaceuticals Ltd | Tetrahydroisoquinoline derivatives to enhance memory function |
US7834028B2 (en) | 2006-04-26 | 2010-11-16 | Actelion Pharmaceuticals Ltd. | Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists |
KR101220182B1 (ko) | 2009-02-25 | 2013-01-11 | 에스케이바이오팜 주식회사 | 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법 |
CN105315204B (zh) * | 2014-07-04 | 2018-02-09 | 中南大学 | 7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途 |
CN105585527B (zh) * | 2015-12-17 | 2018-06-26 | 浙江工业大学 | 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用 |
CN105461626B (zh) * | 2015-12-17 | 2018-05-08 | 浙江工业大学 | 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用 |
EP3601258B1 (en) * | 2017-03-27 | 2023-08-30 | Bristol-Myers Squibb Company | Substituted isoquionline derivatives as immunomudulators |
CN114591238B (zh) * | 2022-03-25 | 2022-11-15 | 邦恩泰(山东)生物医药科技集团股份有限公司 | 一种异喹啉类药物中间体的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6448269B1 (en) * | 1993-07-22 | 2002-09-10 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
JP3258027B2 (ja) | 1996-03-15 | 2002-02-18 | サマーセット・ファーマシューティカルズ・インコーポレイテッド | セレジリン投与による末梢ニューロパシーの予防および治療方法 |
AU1359801A (en) | 1999-11-05 | 2001-06-06 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
-
2003
- 2003-04-14 PT PT03725018T patent/PT1501804E/pt unknown
- 2003-04-14 PL PL03373697A patent/PL373697A1/xx unknown
- 2003-04-14 WO PCT/EP2003/003845 patent/WO2003091219A1/en active Application Filing
- 2003-04-14 CA CA2483461A patent/CA2483461C/en not_active Expired - Fee Related
- 2003-04-14 AT AT03725018T patent/ATE440821T1/de not_active IP Right Cessation
- 2003-04-14 EP EP03725018A patent/EP1501804B1/en not_active Expired - Lifetime
- 2003-04-14 RU RU2004134575/04A patent/RU2318812C2/ru not_active IP Right Cessation
- 2003-04-14 DK DK03725018T patent/DK1501804T3/da active
- 2003-04-14 KR KR1020047017185A patent/KR100681585B1/ko not_active IP Right Cessation
- 2003-04-14 BR BR0309562-2A patent/BR0309562A/pt not_active IP Right Cessation
- 2003-04-14 SI SI200331658T patent/SI1501804T1/sl unknown
- 2003-04-14 DE DE60328978T patent/DE60328978D1/de not_active Expired - Lifetime
- 2003-04-14 JP JP2003587782A patent/JP4322685B2/ja not_active Expired - Fee Related
- 2003-04-14 MX MXPA04010537A patent/MXPA04010537A/es active IP Right Grant
- 2003-04-14 CN CNB038093766A patent/CN1310890C/zh not_active Expired - Fee Related
- 2003-04-14 NZ NZ535885A patent/NZ535885A/en not_active IP Right Cessation
- 2003-04-14 AU AU2003227614A patent/AU2003227614B2/en not_active Ceased
- 2003-04-14 ES ES03725018T patent/ES2329354T3/es not_active Expired - Lifetime
- 2003-04-16 US US10/417,378 patent/US6818774B2/en not_active Expired - Fee Related
- 2003-04-23 TW TW092109478A patent/TWI278451B/zh not_active IP Right Cessation
- 2003-04-23 PA PA20038572001A patent/PA8572001A1/es unknown
- 2003-04-24 GT GT200300095A patent/GT200300095A/es unknown
- 2003-04-24 AR ARP030101412A patent/AR039651A1/es unknown
- 2003-04-24 PE PE2003000408A patent/PE20040594A1/es not_active Application Discontinuation
- 2003-04-25 MY MYPI20031578A patent/MY133527A/en unknown
- 2003-04-28 UY UY27786A patent/UY27786A1/es not_active Application Discontinuation
-
2004
- 2004-10-12 HR HR20040952A patent/HRP20040952A2/hr not_active Application Discontinuation
- 2004-10-13 ZA ZA200408281A patent/ZA200408281B/xx unknown
- 2004-10-18 IL IL16467704A patent/IL164677A0/xx not_active IP Right Cessation
- 2004-10-22 NO NO20044571A patent/NO20044571L/no not_active Application Discontinuation
-
2006
- 2006-01-13 HK HK06100541A patent/HK1080836A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |