DK0732332T3 - Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf - Google Patents

Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf

Info

Publication number
DK0732332T3
DK0732332T3 DK96103772T DK96103772T DK0732332T3 DK 0732332 T3 DK0732332 T3 DK 0732332T3 DK 96103772 T DK96103772 T DK 96103772T DK 96103772 T DK96103772 T DK 96103772T DK 0732332 T3 DK0732332 T3 DK 0732332T3
Authority
DK
Denmark
Prior art keywords
hydrogen
alkylcarbonyl
hydroxy
integer
benzothienylpiperazines
Prior art date
Application number
DK96103772T
Other languages
English (en)
Inventor
Nicholas J Hirb
John Jurcak
Abdul E Mutlib
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0732332T3 publication Critical patent/DK0732332T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK96103772T 1995-03-17 1996-03-11 Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf DK0732332T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41381895A 1995-03-17 1995-03-17

Publications (1)

Publication Number Publication Date
DK0732332T3 true DK0732332T3 (da) 2002-04-15

Family

ID=23638775

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96103772T DK0732332T3 (da) 1995-03-17 1996-03-11 Substituerede benzothienylpiperaziner, deres anvendelse som lægemidler og fremgangsmåder til fremstilling deraf

Country Status (23)

Country Link
US (1) US5801176A (da)
EP (1) EP0732332B1 (da)
JP (1) JPH093060A (da)
KR (1) KR100402510B1 (da)
CN (1) CN1082959C (da)
AT (1) ATE211137T1 (da)
AU (1) AU700077B2 (da)
CA (1) CA2171695A1 (da)
CZ (1) CZ80496A3 (da)
DE (1) DE69618050T2 (da)
DK (1) DK0732332T3 (da)
ES (1) ES2170177T3 (da)
HU (1) HUP9600665A3 (da)
IL (1) IL117519A (da)
NO (1) NO315652B1 (da)
NZ (1) NZ286186A (da)
PL (1) PL182310B1 (da)
PT (1) PT732332E (da)
RO (1) RO117453B1 (da)
RU (1) RU2157371C2 (da)
SG (1) SG54269A1 (da)
TW (1) TW328957B (da)
ZA (1) ZA962075B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703083A (en) * 1996-04-15 1997-12-30 Neurogen Corporation N-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
US6642228B1 (en) 1999-06-24 2003-11-04 Toray Industries, Inc. α1b-adrenergic receptor antagonists
IL157412A0 (en) * 2001-02-16 2004-03-28 Aventis Pharmaceuticals Inc Av Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
ATE348099T1 (de) * 2001-02-16 2007-01-15 Aventis Pharma Inc Heterocyclische harnstoffderivate und deren verwendung als dopamine d3 receptor liganden
GB0117531D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
US20040116522A1 (en) * 2001-03-30 2004-06-17 Yutaka Yamagata Medicinal solutions
TWI320783B (en) * 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AR055203A1 (es) 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
CN105985314A (zh) * 2015-02-05 2016-10-05 苏州旺山旺水生物医药有限公司 布瑞哌唑类似物的制备方法
CA3161806A1 (en) * 2019-12-24 2021-07-01 Sumitomo Pharma Co., Ltd. Aliphatic acid amide derivative

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA848005B (en) * 1983-10-17 1985-05-29 Duphar Int Res Blood-pressure lowering piperazine derivatives
ATE81123T1 (de) * 1987-11-20 1992-10-15 Hoechst Roussel Pharma 3-(4(1-substituierte-4-piperazinyl)butyl>-4thiazolidinone, verfahren zu deren herstellung und ihre anwendung als arzneimittel.
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
GB9302622D0 (en) * 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
GB9410031D0 (en) * 1994-05-19 1994-07-06 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
PT732332E (pt) 2002-06-28
HUP9600665A3 (en) 1998-08-28
CZ80496A3 (en) 1996-10-16
KR960034201A (ko) 1996-10-22
EP0732332A1 (en) 1996-09-18
ES2170177T3 (es) 2002-08-01
CN1082959C (zh) 2002-04-17
ATE211137T1 (de) 2002-01-15
AU700077B2 (en) 1998-12-17
TW328957B (en) 1998-04-01
PL313251A1 (en) 1996-09-30
RU2157371C2 (ru) 2000-10-10
RO117453B1 (ro) 2002-03-29
HUP9600665A2 (en) 1997-10-28
SG54269A1 (en) 1998-11-16
NO315652B1 (no) 2003-10-06
IL117519A0 (en) 1996-07-23
NO961077L (no) 1996-09-18
CN1139108A (zh) 1997-01-01
AU4811396A (en) 1996-09-26
KR100402510B1 (ko) 2004-03-18
NO961077D0 (no) 1996-03-15
HU9600665D0 (en) 1996-05-28
CA2171695A1 (en) 1996-09-18
PL182310B1 (pl) 2001-12-31
EP0732332B1 (en) 2001-12-19
JPH093060A (ja) 1997-01-07
DE69618050D1 (de) 2002-01-31
DE69618050T2 (de) 2002-07-11
NZ286186A (en) 1997-07-27
US5801176A (en) 1998-09-01
IL117519A (en) 2000-08-31
ZA962075B (en) 1997-12-31

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