ATE66913T1 - Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen. - Google Patents

Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.

Info

Publication number
ATE66913T1
ATE66913T1 AT88114257T AT88114257T ATE66913T1 AT E66913 T1 ATE66913 T1 AT E66913T1 AT 88114257 T AT88114257 T AT 88114257T AT 88114257 T AT88114257 T AT 88114257T AT E66913 T1 ATE66913 T1 AT E66913T1
Authority
AT
Austria
Prior art keywords
lower alkyl
halogen
amino
gastromotor
activating
Prior art date
Application number
AT88114257T
Other languages
English (en)
Inventor
Yasuo Itoh
Hideo Kato
Eiichi Koshinaka
Nobuo Ogawa
Hiroyuki Nishino
Jun Sakaguchi
Original Assignee
Hokuriku Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62221211A external-priority patent/JPS6466153A/ja
Priority claimed from JP62236250A external-priority patent/JPS6479144A/ja
Priority claimed from JP62242765A external-priority patent/JPS6485960A/ja
Priority claimed from JP62249749A external-priority patent/JPH0193568A/ja
Application filed by Hokuriku Pharmaceutical filed Critical Hokuriku Pharmaceutical
Application granted granted Critical
Publication of ATE66913T1 publication Critical patent/ATE66913T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
AT88114257T 1987-09-05 1988-09-01 Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen. ATE66913T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP62221211A JPS6466153A (en) 1987-09-05 1987-09-05 Amide compound and digestive tract motion-activator containing said compound as active ingredient
JP62236250A JPS6479144A (en) 1987-09-22 1987-09-22 Amide compound and agent for promoting motion of digestive tract containing said compound
JP62242765A JPS6485960A (en) 1987-09-29 1987-09-29 Amide compound and reactivator for motion of digestive tube comprising said compound as active ingredient
JP62249749A JPH0193568A (ja) 1987-10-05 1987-10-05 アミド化合物、及びそれを有効成分とする消化管運動賦活剤
EP88114257A EP0306827B1 (de) 1987-09-05 1988-09-01 Amidverbindungen, Verfahren zu ihrer Herstellung und Zusammensetzung zur Aktivierung gastromotorischer Funktionen

Publications (1)

Publication Number Publication Date
ATE66913T1 true ATE66913T1 (de) 1991-09-15

Family

ID=27476995

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88114257T ATE66913T1 (de) 1987-09-05 1988-09-01 Amidverbindungen, verfahren zu ihrer herstellung und zusammensetzung zur aktivierung gastromotorischer funktionen.

Country Status (15)

Country Link
US (1) US4983633A (de)
EP (1) EP0306827B1 (de)
KR (1) KR940000058B1 (de)
AT (1) ATE66913T1 (de)
AU (1) AU606988B2 (de)
BG (1) BG48932A3 (de)
CA (1) CA1335101C (de)
DE (1) DE3864636D1 (de)
DK (1) DK169816B1 (de)
ES (1) ES2037779T3 (de)
FI (1) FI87644C (de)
HU (1) HU198447B (de)
SU (1) SU1627082A3 (de)
UA (1) UA6330A1 (de)
YU (1) YU46706B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
WO1995026953A1 (fr) * 1994-03-30 1995-10-12 Yoshitomi Pharmaceutical Industries, Ltd. Compose d'acide benzoïque et son utilisation comme medicament
KR0147963B1 (ko) * 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
AU1180400A (en) * 1998-11-16 2000-06-05 Hokuriku Seiyaku Co. Ltd Remedies for digestive tract functional disorder
ATE267803T1 (de) 1999-08-07 2004-06-15 Boehringer Ingelheim Pharma Carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
DE10235312A1 (de) 2002-08-01 2004-02-12 Basf Ag Verfahren zur Herstellung von Aminoalkoxybenzylaminen und Aminoalkoxybenzonitrilen als Zwischenprodukte
CN1305837C (zh) * 2004-06-11 2007-03-21 吉林修正药业新药研发中心 一种改进的伊托必利原料药的制备方法
KR100595117B1 (ko) * 2004-07-28 2006-06-30 일양약품주식회사 이토프라이드·염산염 중간체인4-[2-(디메틸아미노)에톡시]벤질아민의 새로운 제조방법
ITMI20042168A1 (it) * 2004-11-12 2005-02-12 Erregierre Spa Processo di preparazione di itopride cloridrato
KR100663167B1 (ko) * 2005-10-27 2007-01-02 동우신테크 주식회사 염산 이토프리드의 제조방법
WO2007074386A2 (en) * 2005-12-28 2007-07-05 Bakulesh Mafatlal Khamar A novel process for synthesis of itopride and it’s novel intermediate-n-(4-hydroxybenzyl)-3,4-dimethoxybenzamide
KR100836528B1 (ko) * 2007-07-25 2008-06-10 주식회사 휴온스 이토프리드 염산염의 제조방법
CN101967103A (zh) * 2010-09-28 2011-02-09 浙江金伯士药业有限公司 一种伊托必利中间体的制备新方法
CN103073446B (zh) * 2011-10-26 2014-12-24 珠海保税区丽珠合成制药有限公司 盐酸伊托必利的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1069640B (de) * 1959-11-26 F. Hoffmann-La Roche S. Co. Aktiengesellschaft, Basel (Schweiz) Verfahren zur Herstellung von anfemetisch wirksamen Benzylaminderivaten
FR1525M (fr) * 1961-07-25 1962-11-16 Ile De France Médicaments antiémétiques nouveaux.
NL130752C (de) * 1964-05-07

Also Published As

Publication number Publication date
FI884077A (fi) 1989-03-06
AU606988B2 (en) 1991-02-21
CA1335101C (en) 1995-04-04
DK492288A (da) 1989-03-06
HUT47531A (en) 1989-03-28
DE3864636D1 (de) 1991-10-10
DK169816B1 (da) 1995-03-06
FI87644C (fi) 1993-02-10
UA6330A1 (uk) 1994-12-29
FI87644B (fi) 1992-10-30
HU198447B (en) 1989-10-30
AU2186288A (en) 1989-03-09
US4983633A (en) 1991-01-08
EP0306827B1 (de) 1991-09-04
EP0306827A1 (de) 1989-03-15
DK492288D0 (da) 1988-09-05
YU160088A (en) 1990-06-30
BG48932A3 (en) 1991-06-14
KR940000058B1 (ko) 1994-01-05
KR890005036A (ko) 1989-05-11
ES2037779T3 (es) 1993-07-01
SU1627082A3 (ru) 1991-02-07
FI884077A0 (fi) 1988-09-05
YU46706B (sh) 1994-04-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time