DE69534029D1 - Herstellung von Camptothecinderivaten durch intramolekulare Cyclisierung - Google Patents
Herstellung von Camptothecinderivaten durch intramolekulare CyclisierungInfo
- Publication number
- DE69534029D1 DE69534029D1 DE69534029T DE69534029T DE69534029D1 DE 69534029 D1 DE69534029 D1 DE 69534029D1 DE 69534029 T DE69534029 T DE 69534029T DE 69534029 T DE69534029 T DE 69534029T DE 69534029 D1 DE69534029 D1 DE 69534029D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- intramolecular cyclization
- camptothecin derivatives
- chem
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/237,081 US5491237A (en) | 1994-05-03 | 1994-05-03 | Intermediates in pharmaceutical camptothecin preparation |
US237081 | 1994-05-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69534029D1 true DE69534029D1 (de) | 2005-03-31 |
DE69534029T2 DE69534029T2 (de) | 2006-01-12 |
Family
ID=22892263
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69528762T Expired - Fee Related DE69528762T2 (de) | 1994-05-03 | 1995-05-02 | Herstellung von camptothecinderivaten durch intramolekulare cyclisierung |
DE69532634T Expired - Fee Related DE69532634T2 (de) | 1994-05-03 | 1995-05-02 | Zwischenprodukte für die Herstellung einer pharmazeutischen Campothecin-Zubereitung |
DE69534029T Expired - Fee Related DE69534029T2 (de) | 1994-05-03 | 1995-05-02 | Herstellung von Camptothecinderivaten durch intramolekulare Cyclisierung |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69528762T Expired - Fee Related DE69528762T2 (de) | 1994-05-03 | 1995-05-02 | Herstellung von camptothecinderivaten durch intramolekulare cyclisierung |
DE69532634T Expired - Fee Related DE69532634T2 (de) | 1994-05-03 | 1995-05-02 | Zwischenprodukte für die Herstellung einer pharmazeutischen Campothecin-Zubereitung |
Country Status (10)
Country | Link |
---|---|
US (4) | US5491237A (de) |
EP (3) | EP0758335B1 (de) |
JP (2) | JPH09512559A (de) |
AT (3) | ATE227292T1 (de) |
AU (2) | AU2381695A (de) |
DE (3) | DE69528762T2 (de) |
DK (1) | DK0758335T3 (de) |
ES (3) | ES2219661T3 (de) |
HK (1) | HK1052687A1 (de) |
WO (2) | WO1995029917A2 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
US6207832B1 (en) * | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
EP1488809A1 (de) | 2001-01-16 | 2004-12-22 | Glaxo Group Limited | Pharmazeutische Mischung gegen Krebs, die ein 4-Chinazolinamin in Kombination mit einem anderen antineoplastischen Wirkstoff enthält |
US6809210B2 (en) | 2001-06-12 | 2004-10-26 | Lucent Technologies Inc. | Method of solvating a metal in an aromatic organic liquid |
US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
US8492456B2 (en) * | 2004-02-09 | 2013-07-23 | Hewlett-Packard Development Company, L.P. | Ink compositions for ink-jet printing |
MX2007010033A (es) * | 2005-02-22 | 2007-10-04 | Hoffmann La Roche | Nueva sintesis de una subunidad de camptotecina. |
TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
US20110160130A1 (en) * | 2007-02-16 | 2011-06-30 | Connie Erickson-Miller | Cancer treatment method |
UY30915A1 (es) | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
US20110129550A1 (en) * | 2007-02-16 | 2011-06-02 | Connie Erickson-Miller | Cancer treatment method |
PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
AU2008310894B2 (en) * | 2007-10-09 | 2012-07-26 | Glaxosmithkline Llc | Thrombopoietin receptor agonist (TpoRA) kills acute human myeloid leukemia cells |
ES2548141T3 (es) | 2008-11-20 | 2015-10-14 | Glaxosmithkline Llc | Compuestos químicos |
EP4242206A1 (de) | 2009-01-30 | 2023-09-13 | Novartis AG | Kristallines n-{(1-s)-2-amino-1-[(3-fluorphenyl)methyl]ethyl}-5-chlor-4-(4-chlor-1-methyl-1h-pyrazol-5-yl)-2-thiophencarboxamid hydrochlorid |
US8410095B2 (en) | 2009-05-20 | 2013-04-02 | Glaxosmithkline Llc | Thiazolopyrimidinone derivatives as PI3 kinase inhibitors |
CN101591342B (zh) * | 2009-07-03 | 2011-07-27 | 华东师范大学 | 用于喜树碱类化合物制备的关键中间体合成方法 |
AU2010286691A1 (en) | 2009-08-26 | 2012-04-19 | Cylene Pharmaceuticals, Inc. | Condensed quinolines as protein kinase modulators |
BR112012024380A2 (pt) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | compostos químicos |
KR101594002B1 (ko) | 2010-10-06 | 2016-02-15 | 글락소스미스클라인 엘엘씨 | Pi3 키나제 억제제로서의 벤즈이미다졸 유도체 |
TWI505828B (zh) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產(第二)有限公司 | 新穎醫藥組成物 |
CN104302292A (zh) | 2011-11-22 | 2015-01-21 | 德西费拉制药有限责任公司 | 表现出抗癌和抗增殖活性的吡啶酮酰胺以及类似物 |
WO2013113796A1 (en) | 2012-01-31 | 2013-08-08 | Smithkline Beecham (Cork) Limited | Method of treating cancer |
JP6430390B2 (ja) | 2012-11-20 | 2018-11-28 | ジェネンテック, インコーポレイテッド | T790mを含むegfr変異体の阻害剤としてのアミノピリミジン化合物 |
PE20151024A1 (es) | 2012-11-30 | 2015-07-27 | Glaxosmithkline Llc | Composicion farmaceutica novedosa |
RU2015132907A (ru) | 2013-01-09 | 2017-02-14 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Комбинация |
EP2943484B1 (de) | 2013-01-10 | 2017-10-25 | Glaxosmithkline Intellectual Property (No. 2) Limited | Fettsäuresynthasehemmer |
WO2015056180A1 (en) | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
EP3111222A1 (de) | 2014-02-26 | 2017-01-04 | Glaxosmithkline Intellectual Property (No. 2) Limited | Verfahren zur behandlung von krebspatienten mit reaktion auf ezh2-inhibitor gsk126 |
WO2016055935A1 (en) | 2014-10-06 | 2016-04-14 | Glaxosmithkline Intellectual Property (No.2) Limited | Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist |
WO2016059602A2 (en) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
US20180230431A1 (en) | 2015-08-07 | 2018-08-16 | Glaxosmithkline Intellectual Property Development Limited | Combination Therapy |
CA3006934A1 (en) | 2015-12-01 | 2017-06-08 | Glaxosmithkline Intellectual Property Development Limited | Combination of antibodies targeting bcma, pd-1 and ox40 in cancer treatments and uses therof |
WO2017098421A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Benzothiadiazine compounds |
WO2017153952A1 (en) | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
US11649289B2 (en) | 2016-08-04 | 2023-05-16 | Glaxosmithkline Intellectual Property Development Limited | Anti-ICOS and anti-PD-1 antibody combination therapy |
US20190365710A1 (en) | 2016-12-01 | 2019-12-05 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
AU2018297656B2 (en) | 2017-07-05 | 2021-09-16 | Novartis Ag | Novel pharmaceutical composition |
TW201922721A (zh) | 2017-09-07 | 2019-06-16 | 英商葛蘭素史克智慧財產發展有限公司 | 化學化合物 |
WO2019053617A1 (en) | 2017-09-12 | 2019-03-21 | Glaxosmithkline Intellectual Property Development Limited | CHEMICAL COMPOUNDS |
MX2021009189A (es) | 2019-02-01 | 2021-11-12 | Glaxosmithkline Ip Dev Ltd | Belantamab mafodotin en combinación con pembrolizumab para el tratamiento del cáncer. |
JP2022539178A (ja) | 2019-06-26 | 2022-09-07 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Il1rap結合タンパク質 |
WO2021018941A1 (en) | 2019-07-31 | 2021-02-04 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating cancer |
WO2021046293A1 (en) | 2019-09-06 | 2021-03-11 | Glaxosmithkline Intellectual Property Development Limited | Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and tremelimumab |
WO2021043961A1 (en) | 2019-09-06 | 2021-03-11 | Glaxosmithkline Intellectual Property Development Limited | Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy |
BR112022014562A2 (pt) | 2020-01-28 | 2022-09-13 | Glaxosmithkline Ip Dev Ltd | Tratamentos de combinação, usos e métodos dos mesmos |
Family Cites Families (50)
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DE152774C (de) * | ||||
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
DD152774A1 (de) * | 1980-08-25 | 1981-12-09 | Brunhilde Gorski | Verfahren zur abtrennung von palladium und technetium aus loesungen der kernbrennstoffwiederaufbereitung |
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
US4413118A (en) * | 1981-03-02 | 1983-11-01 | Merck & Co., Inc. | Process for removal of homogeneous catalyst group VIII metals from process streams |
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
EP0220601B1 (de) * | 1985-10-21 | 1991-12-11 | Daiichi Seiyaku Co., Ltd. | Pyranoindolizinderivate und Verfahren zu ihrer Herstellung |
JPS6314824A (ja) * | 1986-07-04 | 1988-01-22 | Tanaka Kikinzoku Kogyo Kk | 貴金属元素の回収方法 |
JPS6333355A (ja) * | 1986-07-29 | 1988-02-13 | Mitsui Toatsu Chem Inc | シスチンの精製方法 |
US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
US5227380A (en) * | 1987-03-31 | 1993-07-13 | Research Triangle Institute | Pharmaceutical compositions and methods employing camptothecins |
US5122526A (en) * | 1987-03-31 | 1992-06-16 | Research Triangle Institute | Camptothecin and analogs thereof and pharmaceutical compositions and method using them |
US5244903A (en) * | 1987-03-31 | 1993-09-14 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
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US5106742A (en) * | 1987-03-31 | 1992-04-21 | Wall Monroe E | Camptothecin analogs as potent inhibitors of topoisomerase I |
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US5180722A (en) * | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
US5260461A (en) * | 1988-01-11 | 1993-11-09 | Massachusetts Institute Of Technology | Ligands for ADH: cinchona alkaloids and moderately sized organic substituents linked through a planar aromatic spacer group |
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US4871855A (en) * | 1988-01-11 | 1989-10-03 | Massachusetts Institute Of Technology | Ligand-accelerated catalytic asymmetric dihydroxylation using dihydroquinidine and dihydroquinidine esters as ligands |
US4965364A (en) * | 1988-02-23 | 1990-10-23 | Massachusetts Institute Of Technology | Ligand-accelerated catalytic asymmetric dihydroxylation |
US5227543A (en) * | 1988-01-11 | 1993-07-13 | Massachusetts Institute Of Technology | Facilitation of turnover in the ADH by additives which catalyze the hydrolysis of the OS(VI) glycolate esters |
EP0658532B1 (de) * | 1988-01-11 | 1999-04-07 | Massachusetts Institute Of Technology | Durch einen Komplexbilder beschleunigte asymmetrische katalytische Dihydroxylierung |
JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
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US5191082A (en) * | 1990-12-20 | 1993-03-02 | North Carolina State University | Camptothecin intermediate and method of making camptothecin intermediates |
US5264579A (en) * | 1990-12-20 | 1993-11-23 | North Carolina State University | D ring intermediates for the synthesis of camptothecin and camptothecin analogs |
US5212317A (en) * | 1990-12-20 | 1993-05-18 | North Carolina State University | Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs |
US5254690A (en) * | 1990-12-20 | 1993-10-19 | North Carolina State University | Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs |
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US5258516A (en) * | 1990-12-20 | 1993-11-02 | Nc State University | Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs |
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US5243050A (en) * | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
US5247089A (en) * | 1990-12-20 | 1993-09-21 | North Carolina State University | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs |
US5315007A (en) * | 1990-12-20 | 1994-05-24 | North Carolina State University | Process for making DE ring intermediates for the synthesis of camptothecin and camptothecin analogs |
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WO1993016698A1 (en) * | 1992-02-21 | 1993-09-02 | Smithkline Beecham Corporation | SUBSTITUTED FURO[3',4':6,7]INDOLIZINO[1,2-b]QUINOLINONES |
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AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
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-
1994
- 1994-05-03 US US08/237,081 patent/US5491237A/en not_active Expired - Lifetime
-
1995
- 1995-05-02 ES ES95917217T patent/ES2219661T3/es not_active Expired - Lifetime
- 1995-05-02 EP EP95918904A patent/EP0758335B1/de not_active Expired - Lifetime
- 1995-05-02 DK DK95918904T patent/DK0758335T3/da active
- 1995-05-02 JP JP7528482A patent/JPH09512559A/ja active Pending
- 1995-05-02 WO PCT/US1995/005425 patent/WO1995029917A2/en active IP Right Grant
- 1995-05-02 ES ES95918904T patent/ES2188661T3/es not_active Expired - Lifetime
- 1995-05-02 DE DE69528762T patent/DE69528762T2/de not_active Expired - Fee Related
- 1995-05-02 AT AT95918904T patent/ATE227292T1/de not_active IP Right Cessation
- 1995-05-02 AU AU23816/95A patent/AU2381695A/en not_active Abandoned
- 1995-05-02 AU AU24651/95A patent/AU2465195A/en not_active Abandoned
- 1995-05-02 DE DE69532634T patent/DE69532634T2/de not_active Expired - Fee Related
- 1995-05-02 US US08/732,435 patent/US5840898A/en not_active Expired - Fee Related
- 1995-05-02 DE DE69534029T patent/DE69534029T2/de not_active Expired - Fee Related
- 1995-05-02 AT AT02014439T patent/ATE289608T1/de not_active IP Right Cessation
- 1995-05-02 JP JP7528481A patent/JPH09512558A/ja not_active Ceased
- 1995-05-02 EP EP95917217A patent/EP0758333B1/de not_active Expired - Lifetime
- 1995-05-02 WO PCT/US1995/005427 patent/WO1995029919A1/en active IP Right Grant
- 1995-05-02 AT AT95917217T patent/ATE260919T1/de not_active IP Right Cessation
- 1995-05-02 ES ES02014439T patent/ES2238523T3/es not_active Expired - Lifetime
- 1995-05-02 EP EP02014439A patent/EP1254908B9/de not_active Expired - Lifetime
- 1995-05-02 US US08/737,032 patent/US6063923A/en not_active Expired - Fee Related
-
2000
- 2000-04-19 US US09/552,214 patent/US6462196B1/en not_active Expired - Fee Related
-
2003
- 2003-05-05 HK HK03103188A patent/HK1052687A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0758333A1 (de) | 1997-02-19 |
JPH09512559A (ja) | 1997-12-16 |
DE69528762D1 (de) | 2002-12-12 |
ES2219661T3 (es) | 2004-12-01 |
WO1995029917A3 (en) | 1995-12-28 |
HK1052687A1 (en) | 2003-09-26 |
ES2238523T3 (es) | 2005-09-01 |
JPH09512558A (ja) | 1997-12-16 |
ATE227292T1 (de) | 2002-11-15 |
DE69532634D1 (de) | 2004-04-08 |
US5491237A (en) | 1996-02-13 |
DE69534029T2 (de) | 2006-01-12 |
DE69532634T2 (de) | 2005-03-10 |
US5840898A (en) | 1998-11-24 |
EP1254908B9 (de) | 2005-09-21 |
WO1995029917A2 (en) | 1995-11-09 |
EP1254908A1 (de) | 2002-11-06 |
EP0758335B1 (de) | 2002-11-06 |
AU2465195A (en) | 1995-11-29 |
ATE260919T1 (de) | 2004-03-15 |
DE69528762T2 (de) | 2003-07-17 |
US6063923A (en) | 2000-05-16 |
EP0758335A1 (de) | 1997-02-19 |
DK0758335T3 (da) | 2003-03-17 |
EP1254908B1 (de) | 2005-02-23 |
EP0758333B1 (de) | 2004-03-03 |
US6462196B1 (en) | 2002-10-08 |
ES2188661T3 (es) | 2003-07-01 |
WO1995029919A1 (en) | 1995-11-09 |
AU2381695A (en) | 1995-11-29 |
ATE289608T1 (de) | 2005-03-15 |
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