HK1052687A1 - Preparation of a camptothecin derivative by intramolecular cyclisation. - Google Patents
Preparation of a camptothecin derivative by intramolecular cyclisation.Info
- Publication number
- HK1052687A1 HK1052687A1 HK03103188A HK03103188A HK1052687A1 HK 1052687 A1 HK1052687 A1 HK 1052687A1 HK 03103188 A HK03103188 A HK 03103188A HK 03103188 A HK03103188 A HK 03103188A HK 1052687 A1 HK1052687 A1 HK 1052687A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- camptothecin derivative
- intramolecular cyclisation
- chem
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/237,081 US5491237A (en) | 1994-05-03 | 1994-05-03 | Intermediates in pharmaceutical camptothecin preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1052687A1 true HK1052687A1 (en) | 2003-09-26 |
Family
ID=22892263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03103188A HK1052687A1 (en) | 1994-05-03 | 2003-05-05 | Preparation of a camptothecin derivative by intramolecular cyclisation. |
Country Status (10)
Country | Link |
---|---|
US (4) | US5491237A (xx) |
EP (3) | EP0758333B1 (xx) |
JP (2) | JPH09512558A (xx) |
AT (3) | ATE289608T1 (xx) |
AU (2) | AU2465195A (xx) |
DE (3) | DE69532634T2 (xx) |
DK (1) | DK0758335T3 (xx) |
ES (3) | ES2219661T3 (xx) |
HK (1) | HK1052687A1 (xx) |
WO (2) | WO1995029917A2 (xx) |
Families Citing this family (51)
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US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
US6207832B1 (en) * | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
EP1512413A3 (en) | 2001-01-16 | 2009-09-23 | Glaxo Group Limited | Pharmaceutical combination containing a 4-quinazolineamine and another anti-neoplastic agent for the treatment of cancer |
US6809210B2 (en) | 2001-06-12 | 2004-10-26 | Lucent Technologies Inc. | Method of solvating a metal in an aromatic organic liquid |
US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
CZ299329B6 (cs) * | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
CZ299593B6 (cs) * | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
US8492456B2 (en) * | 2004-02-09 | 2013-07-23 | Hewlett-Packard Development Company, L.P. | Ink compositions for ink-jet printing |
ATE531719T1 (de) * | 2005-02-22 | 2011-11-15 | Hoffmann La Roche | Neue synthese einer camptothecin-untereinheit |
TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
UY30915A1 (es) | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
US20110129550A1 (en) * | 2007-02-16 | 2011-06-02 | Connie Erickson-Miller | Cancer treatment method |
US20110160130A1 (en) * | 2007-02-16 | 2011-06-30 | Connie Erickson-Miller | Cancer treatment method |
PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
CN101888841B (zh) * | 2007-10-09 | 2012-09-26 | 宾夕法尼亚大学理事会 | 血小板生成素受体激动剂(TpoRA)杀死急性人骨髓样白血病细胞 |
US8697685B2 (en) | 2008-11-20 | 2014-04-15 | Glaxosmithkline Llc | Chemical compounds |
EP2400964A4 (en) | 2009-01-30 | 2012-08-01 | Glaxosmithkline Llc | CRYSTALLINE FORM OF N - {(1-5) -2-AMINO-1 - [(3-FLUOROPHENYL) METHYL] ETHYL} -5-CHLORO-4- (4-CHLORO-1-METHYL-1H-PYRAZOL) CHLOROHYDRATE 5-YL) -2-THIOPHENE CARBOXAMIDE |
US8410095B2 (en) | 2009-05-20 | 2013-04-02 | Glaxosmithkline Llc | Thiazolopyrimidinone derivatives as PI3 kinase inhibitors |
CN101591342B (zh) * | 2009-07-03 | 2011-07-27 | 华东师范大学 | 用于喜树碱类化合物制备的关键中间体合成方法 |
US20110065698A1 (en) | 2009-08-26 | 2011-03-17 | Cylene Pharmaceuticals, Inc. | Novel protein kinase modulators |
BR112012024380A2 (pt) | 2010-03-25 | 2015-09-15 | Glaxosmithkline Llc | compostos químicos |
EA022623B1 (ru) | 2010-10-06 | 2016-02-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Производные бензимидазола в качестве ингибиторов pi3-киназ |
TWI505828B (zh) | 2010-12-20 | 2015-11-01 | 葛蘭素史克智慧財產(第二)有限公司 | 新穎醫藥組成物 |
SG11201402531XA (en) | 2011-11-22 | 2014-08-28 | Deciphera Pharmaceuticals Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities |
KR20140117644A (ko) | 2012-01-31 | 2014-10-07 | 스미스클라인 비이참 (코르크) 리미티드 | 암을 치료하는 방법 |
MX2015006152A (es) | 2012-11-20 | 2016-01-20 | Genentech Inc | Compuestos de aminopirimidina como inhibidores de mutantes de egfr que contienen t7 9 0m. |
EP3400933A1 (en) | 2012-11-30 | 2018-11-14 | Novartis AG | Novel pharmaceutical trametinib composition |
US20150342957A1 (en) | 2013-01-09 | 2015-12-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Combination |
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WO2015056180A1 (en) | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
US20160361309A1 (en) | 2014-02-26 | 2016-12-15 | Glaxosmithkline Intellectual Property (No.2) Limited | Methods of treating cancer patients responding to ezh2 inhibitor gsk126 |
WO2016055935A1 (en) | 2014-10-06 | 2016-04-14 | Glaxosmithkline Intellectual Property (No.2) Limited | Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist |
WO2016059602A2 (en) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
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TW201922721A (zh) | 2017-09-07 | 2019-06-16 | 英商葛蘭素史克智慧財產發展有限公司 | 化學化合物 |
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CA3143211A1 (en) | 2019-06-26 | 2020-12-30 | Glaxosmithkline Intellectual Property Development Limited | Il1rap binding proteins |
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CN115038466A (zh) | 2020-01-28 | 2022-09-09 | 葛兰素史密斯克莱知识产权发展有限公司 | 联合治疗及其用途和方法 |
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US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
DD152774A1 (de) * | 1980-08-25 | 1981-12-09 | Brunhilde Gorski | Verfahren zur abtrennung von palladium und technetium aus loesungen der kernbrennstoffwiederaufbereitung |
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
US4413118A (en) * | 1981-03-02 | 1983-11-01 | Merck & Co., Inc. | Process for removal of homogeneous catalyst group VIII metals from process streams |
US4473692A (en) * | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
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JPS6314824A (ja) * | 1986-07-04 | 1988-01-22 | Tanaka Kikinzoku Kogyo Kk | 貴金属元素の回収方法 |
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US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
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US5243050A (en) * | 1990-12-20 | 1993-09-07 | North Carolina State University | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs |
US5258516A (en) * | 1990-12-20 | 1993-11-02 | Nc State University | Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs |
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US5200524A (en) * | 1990-12-20 | 1993-04-06 | North Carolina State University | Camptothecin intermediates and method of making same |
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DK0540099T3 (da) * | 1991-10-29 | 1996-06-17 | Glaxo Wellcome Inc | Vandopløselige camptothecinderivater |
EP0556585A3 (en) * | 1992-01-24 | 1993-09-01 | Takeda Chemical Industries, Ltd. | Condensed camptothecin derivatives their production and use as antitumor agents |
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-
1994
- 1994-05-03 US US08/237,081 patent/US5491237A/en not_active Expired - Lifetime
-
1995
- 1995-05-02 DK DK95918904T patent/DK0758335T3/da active
- 1995-05-02 ES ES95917217T patent/ES2219661T3/es not_active Expired - Lifetime
- 1995-05-02 JP JP7528481A patent/JPH09512558A/ja not_active Ceased
- 1995-05-02 WO PCT/US1995/005425 patent/WO1995029917A2/en active IP Right Grant
- 1995-05-02 US US08/732,435 patent/US5840898A/en not_active Expired - Fee Related
- 1995-05-02 DE DE69532634T patent/DE69532634T2/de not_active Expired - Fee Related
- 1995-05-02 AT AT02014439T patent/ATE289608T1/de not_active IP Right Cessation
- 1995-05-02 AT AT95918904T patent/ATE227292T1/de not_active IP Right Cessation
- 1995-05-02 EP EP95917217A patent/EP0758333B1/en not_active Expired - Lifetime
- 1995-05-02 DE DE69534029T patent/DE69534029T2/de not_active Expired - Fee Related
- 1995-05-02 AU AU24651/95A patent/AU2465195A/en not_active Abandoned
- 1995-05-02 JP JP7528482A patent/JPH09512559A/ja active Pending
- 1995-05-02 US US08/737,032 patent/US6063923A/en not_active Expired - Fee Related
- 1995-05-02 EP EP02014439A patent/EP1254908B9/en not_active Expired - Lifetime
- 1995-05-02 AU AU23816/95A patent/AU2381695A/en not_active Abandoned
- 1995-05-02 WO PCT/US1995/005427 patent/WO1995029919A1/en active IP Right Grant
- 1995-05-02 DE DE69528762T patent/DE69528762T2/de not_active Expired - Fee Related
- 1995-05-02 ES ES02014439T patent/ES2238523T3/es not_active Expired - Lifetime
- 1995-05-02 AT AT95917217T patent/ATE260919T1/de not_active IP Right Cessation
- 1995-05-02 EP EP95918904A patent/EP0758335B1/en not_active Expired - Lifetime
- 1995-05-02 ES ES95918904T patent/ES2188661T3/es not_active Expired - Lifetime
-
2000
- 2000-04-19 US US09/552,214 patent/US6462196B1/en not_active Expired - Fee Related
-
2003
- 2003-05-05 HK HK03103188A patent/HK1052687A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0758335T3 (da) | 2003-03-17 |
DE69532634T2 (de) | 2005-03-10 |
ATE227292T1 (de) | 2002-11-15 |
WO1995029919A1 (en) | 1995-11-09 |
ES2238523T3 (es) | 2005-09-01 |
AU2381695A (en) | 1995-11-29 |
DE69534029D1 (de) | 2005-03-31 |
JPH09512558A (ja) | 1997-12-16 |
ATE260919T1 (de) | 2004-03-15 |
DE69528762D1 (de) | 2002-12-12 |
DE69532634D1 (de) | 2004-04-08 |
EP0758333A1 (en) | 1997-02-19 |
US6462196B1 (en) | 2002-10-08 |
ES2219661T3 (es) | 2004-12-01 |
JPH09512559A (ja) | 1997-12-16 |
US5491237A (en) | 1996-02-13 |
WO1995029917A3 (en) | 1995-12-28 |
AU2465195A (en) | 1995-11-29 |
DE69528762T2 (de) | 2003-07-17 |
US5840898A (en) | 1998-11-24 |
EP0758335B1 (en) | 2002-11-06 |
WO1995029917A2 (en) | 1995-11-09 |
EP0758335A1 (en) | 1997-02-19 |
ATE289608T1 (de) | 2005-03-15 |
DE69534029T2 (de) | 2006-01-12 |
EP1254908B1 (en) | 2005-02-23 |
ES2188661T3 (es) | 2003-07-01 |
EP1254908A1 (en) | 2002-11-06 |
EP1254908B9 (en) | 2005-09-21 |
EP0758333B1 (en) | 2004-03-03 |
US6063923A (en) | 2000-05-16 |
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