EP0555347A4 - Substituted indolizino 1,2-b)quinolinones - Google Patents

Substituted indolizino 1,2-b)quinolinones

Info

Publication number
EP0555347A4
EP0555347A4 EP91920258A EP91920258A EP0555347A4 EP 0555347 A4 EP0555347 A4 EP 0555347A4 EP 91920258 A EP91920258 A EP 91920258A EP 91920258 A EP91920258 A EP 91920258A EP 0555347 A4 EP0555347 A4 EP 0555347A4
Authority
EP
European Patent Office
Prior art keywords
quinolinones
indolizino
substituted
substituted indolizino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP91920258A
Other versions
EP0555347A1 (en
Inventor
Hameed Sheik Allaudeen
David Alan Berges
Robert Philip Hertzberg
Randall Keith Johnson
William Dennis Kingsbury
Stephen Robert Petteway Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0555347A1 publication Critical patent/EP0555347A1/en
Publication of EP0555347A4 publication Critical patent/EP0555347A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP91920258A 1990-10-31 1991-10-30 Substituted indolizino 1,2-b)quinolinones Ceased EP0555347A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60621690A 1990-10-31 1990-10-31
US606216 1990-10-31
US78306391A 1991-10-25 1991-10-25
US783063 1991-10-25

Publications (2)

Publication Number Publication Date
EP0555347A1 EP0555347A1 (en) 1993-08-18
EP0555347A4 true EP0555347A4 (en) 1995-01-11

Family

ID=27085175

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91920258A Ceased EP0555347A4 (en) 1990-10-31 1991-10-30 Substituted indolizino 1,2-b)quinolinones

Country Status (9)

Country Link
EP (1) EP0555347A4 (en)
JP (1) JPH06502642A (en)
KR (1) KR930702289A (en)
AU (1) AU8940491A (en)
CA (1) CA2095219A1 (en)
IE (1) IE913790A1 (en)
NZ (1) NZ240406A (en)
PT (1) PT99412A (en)
WO (1) WO1992007856A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883255A (en) * 1990-10-31 1999-03-16 Smithkline Beecham Corporation Substituted indolizino 1,2-b!quinolinones
CA2118324A1 (en) * 1992-04-17 1993-10-28 David A. Berges Substituted indolizino¬1,2-b|quinolinones
MX9403275A (en) * 1993-05-03 1995-01-31 Smithkline Beecham Corp METHYLENDIOXI [3, '4': 6,7] INDOLIZINO- [1,2-B] QUINOLINONAS SUBSTITUTED.
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
ATE275132T1 (en) * 1995-06-27 2004-09-15 Takeda Chemical Industries Ltd 4-ACYLAMINO(HALOGEN)ALKYL-QUINOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MELATONIN AGONISTS
EA001400B1 (en) * 1995-11-02 2001-02-26 Глаксо Веллкам Инк. Method for preparing camptothecin derivatives
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
JP3046258B2 (en) * 1997-04-11 2000-05-29 株式会社ヤクルト本社 Method for producing 1-chlorocarbonyl-4-piperidinopiperidine or hydrochloride thereof
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
ES2421511T3 (en) 2001-12-21 2013-09-03 X Ceptor Therapeutics Inc LXR modulators
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
US7064202B1 (en) * 2003-05-12 2006-06-20 University Of Kentucky Research Foundation Camptothecin intermediates and prodrugs and methods of preparation thereof
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
WO2006019955A2 (en) * 2004-07-14 2006-02-23 President And Fellows Of Harvard College Antiviral methods and compositions
US9888690B2 (en) 2011-06-22 2018-02-13 Council Of Scientific & Industrial Research Insecticidal compounds from Nothapodites foetida and process for the extraction thereof
KR101721029B1 (en) 2014-10-16 2017-03-29 연세대학교 산학협력단 Indolizino[3,2-c]quinoline derivatives, pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for treatment of cystic fibrosis containing the same as active ingredient
KR101850607B1 (en) 2015-07-23 2018-04-19 서울대학교산학협력단 Indolizino[3,2-c]quinolines based fluorescence probe
WO2017014601A1 (en) * 2015-07-23 2017-01-26 서울대학교 산학협력단 Indolizino [3,2-c] quinoline-based fluorescent probe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (en) * 1975-02-07 1983-06-24 日本ケミフア （株） Process for producing 7-alkoxycarbonyl-8-methylindolizino[1,2-b]quinolin-9(11H)-one

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 85, no. 23, 1976, Columbus, Ohio, US; abstract no. 177759k, T. KAMETANI: "Mappicine" page 558; *
CHEMICAL ABSTRACTS, vol. 87, no. 3, 1977, Columbus, Ohio, US; abstract no. 23591d, T. KAMETANI: "Mappicine" page 684; *
See also references of WO9207856A1 *

Also Published As

Publication number Publication date
PT99412A (en) 1992-10-30
WO1992007856A1 (en) 1992-05-14
AU8940491A (en) 1992-05-26
IE913790A1 (en) 1992-05-22
JPH06502642A (en) 1994-03-24
CA2095219A1 (en) 1992-05-01
EP0555347A1 (en) 1993-08-18
NZ240406A (en) 1994-05-26
KR930702289A (en) 1993-09-08

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