ATE260919T1 - Zwischenprodukte für die herstellung von pharmazeutischem camptothecin - Google Patents

Zwischenprodukte für die herstellung von pharmazeutischem camptothecin

Info

Publication number
ATE260919T1
ATE260919T1 AT95917217T AT95917217T ATE260919T1 AT E260919 T1 ATE260919 T1 AT E260919T1 AT 95917217 T AT95917217 T AT 95917217T AT 95917217 T AT95917217 T AT 95917217T AT E260919 T1 ATE260919 T1 AT E260919T1
Authority
AT
Austria
Prior art keywords
camptothecin
pharmaceutical
production
intermediate products
chem
Prior art date
Application number
AT95917217T
Other languages
English (en)
Inventor
Francis Gerard Fang
Melissa Williams Lowery
Shiping Xie
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Application granted granted Critical
Publication of ATE260919T1 publication Critical patent/ATE260919T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95917217T 1994-05-03 1995-05-02 Zwischenprodukte für die herstellung von pharmazeutischem camptothecin ATE260919T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/237,081 US5491237A (en) 1994-05-03 1994-05-03 Intermediates in pharmaceutical camptothecin preparation
PCT/US1995/005425 WO1995029917A2 (en) 1994-05-03 1995-05-02 Intermediates in pharmaceutical camptothecin preparation

Publications (1)

Publication Number Publication Date
ATE260919T1 true ATE260919T1 (de) 2004-03-15

Family

ID=22892263

Family Applications (3)

Application Number Title Priority Date Filing Date
AT02014439T ATE289608T1 (de) 1994-05-03 1995-05-02 Herstellung von camptothecinderivaten durch intramolekulare cyclisierung
AT95918904T ATE227292T1 (de) 1994-05-03 1995-05-02 Herstellung von camptothecinderivaten durch intramolekulare cyclisierung
AT95917217T ATE260919T1 (de) 1994-05-03 1995-05-02 Zwischenprodukte für die herstellung von pharmazeutischem camptothecin

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT02014439T ATE289608T1 (de) 1994-05-03 1995-05-02 Herstellung von camptothecinderivaten durch intramolekulare cyclisierung
AT95918904T ATE227292T1 (de) 1994-05-03 1995-05-02 Herstellung von camptothecinderivaten durch intramolekulare cyclisierung

Country Status (10)

Country Link
US (4) US5491237A (de)
EP (3) EP0758333B1 (de)
JP (2) JPH09512558A (de)
AT (3) ATE289608T1 (de)
AU (2) AU2465195A (de)
DE (3) DE69532634T2 (de)
DK (1) DK0758335T3 (de)
ES (3) ES2219661T3 (de)
HK (1) HK1052687A1 (de)
WO (2) WO1995029917A2 (de)

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JP2019505476A (ja) 2015-12-01 2019-02-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 組合せ処置およびその方法
WO2017098421A1 (en) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Benzothiadiazine compounds
WO2017153952A1 (en) 2016-03-10 2017-09-14 Glaxosmithkline Intellectual Property Development Limited 5-sulfamoyl-2-hydroxybenzamide derivatives
EP3494140A1 (de) 2016-08-04 2019-06-12 GlaxoSmithKline Intellectual Property Development Ltd Anti-icos- und anti-pd-1-antikörper-kombinationstherapie
EP3548638A1 (de) 2016-12-01 2019-10-09 GlaxoSmithKline Intellectual Property Development Limited Verfahren zur behandlung von krebs
AU2018297656B2 (en) 2017-07-05 2021-09-16 Novartis Ag Novel pharmaceutical composition
TW201922721A (zh) 2017-09-07 2019-06-16 英商葛蘭素史克智慧財產發展有限公司 化學化合物
WO2019053617A1 (en) 2017-09-12 2019-03-21 Glaxosmithkline Intellectual Property Development Limited CHEMICAL COMPOUNDS
MX2021009189A (es) 2019-02-01 2021-11-12 Glaxosmithkline Ip Dev Ltd Belantamab mafodotin en combinación con pembrolizumab para el tratamiento del cáncer.
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WO2021018941A1 (en) 2019-07-31 2021-02-04 Glaxosmithkline Intellectual Property Development Limited Methods of treating cancer
WO2021043961A1 (en) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and chemotherapy
WO2021046289A1 (en) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Dosing regimen for the treatment of cancer with an anti icos agonistic antibody and ipilimumab
CN115038466A (zh) 2020-01-28 2022-09-09 葛兰素史密斯克莱知识产权发展有限公司 联合治疗及其用途和方法

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Also Published As

Publication number Publication date
DK0758335T3 (da) 2003-03-17
DE69532634T2 (de) 2005-03-10
ATE227292T1 (de) 2002-11-15
WO1995029919A1 (en) 1995-11-09
ES2238523T3 (es) 2005-09-01
AU2381695A (en) 1995-11-29
DE69534029D1 (de) 2005-03-31
JPH09512558A (ja) 1997-12-16
DE69528762D1 (de) 2002-12-12
DE69532634D1 (de) 2004-04-08
EP0758333A1 (de) 1997-02-19
US6462196B1 (en) 2002-10-08
ES2219661T3 (es) 2004-12-01
JPH09512559A (ja) 1997-12-16
US5491237A (en) 1996-02-13
WO1995029917A3 (en) 1995-12-28
AU2465195A (en) 1995-11-29
DE69528762T2 (de) 2003-07-17
US5840898A (en) 1998-11-24
EP0758335B1 (de) 2002-11-06
WO1995029917A2 (en) 1995-11-09
HK1052687A1 (en) 2003-09-26
EP0758335A1 (de) 1997-02-19
ATE289608T1 (de) 2005-03-15
DE69534029T2 (de) 2006-01-12
EP1254908B1 (de) 2005-02-23
ES2188661T3 (es) 2003-07-01
EP1254908A1 (de) 2002-11-06
EP1254908B9 (de) 2005-09-21
EP0758333B1 (de) 2004-03-03
US6063923A (en) 2000-05-16

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