ES8606282A1 - Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos - Google Patents

Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos

Info

Publication number
ES8606282A1
ES8606282A1 ES540443A ES540443A ES8606282A1 ES 8606282 A1 ES8606282 A1 ES 8606282A1 ES 540443 A ES540443 A ES 540443A ES 540443 A ES540443 A ES 540443A ES 8606282 A1 ES8606282 A1 ES 8606282A1
Authority
ES
Spain
Prior art keywords
compounds
derivatives
preparing
yes
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540443A
Other languages
English (en)
Other versions
ES540443A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES540443A0 publication Critical patent/ES540443A0/es
Publication of ES8606282A1 publication Critical patent/ES8606282A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS QUINOLIN- Y NAFTIRIDIN-CARBOXILICOS, Y DE SUS SALES DE ADICION DE ACIDO O DE BASE FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES CF O NITROGENO; R1 REPRESENTA HIDROGENO O ALQUILO INFERIOR; Y Z PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE SUSTITUCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R REPRESENTA FLUOR O CLORO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON UNA AMINA CORRESPONDIENTE AL GRUPO REPRESENTADO POR Z. LA REACCION SE LLEVA A CABO EN PRESENCIA O AUSENCIA DE UN DISOLVENTE INERTE, EN PRESENCIA DE UN ACEPTOR DE ACIDOS, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 150JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES540443A 1984-02-17 1985-02-15 Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos Expired ES8606282A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58141084A 1984-02-17 1984-02-17
US69281985A 1985-01-23 1985-01-23

Publications (2)

Publication Number Publication Date
ES540443A0 ES540443A0 (es) 1986-04-16
ES8606282A1 true ES8606282A1 (es) 1986-04-16

Family

ID=27078323

Family Applications (1)

Application Number Title Priority Date Filing Date
ES540443A Expired ES8606282A1 (es) 1984-02-17 1985-02-15 Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos

Country Status (20)

Country Link
EP (1) EP0153828B1 (es)
KR (1) KR900003512B1 (es)
AR (1) AR241593A1 (es)
AU (1) AU566416B2 (es)
CA (1) CA1285279C (es)
DE (1) DE3581090D1 (es)
DK (1) DK165635C (es)
ES (1) ES8606282A1 (es)
FI (1) FI850632L (es)
GR (1) GR850395B (es)
HK (1) HK71393A (es)
HU (1) HU193946B (es)
IE (1) IE58976B1 (es)
IL (1) IL74244A (es)
NO (1) NO162721C (es)
NZ (1) NZ211136A (es)
OA (1) OA07955A (es)
PH (1) PH21230A (es)
PT (1) PT79968B (es)
SG (1) SG56293G (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092012A (en) * 1977-01-13 1978-05-30 Otsuka Koki Co., Ltd. Ratchet type quick feeding mechanism for automobile pantograph jack
JPS58173692U (ja) * 1982-05-15 1983-11-19 株式会社三ツ知 パンタグラフ式ジヤツキ
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3508816A1 (de) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
DE3601567A1 (de) * 1986-01-21 1987-07-23 Bayer Ag 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
US4689423A (en) * 1986-04-01 1987-08-25 Warner-Lambert Company Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds
DE3635062A1 (de) * 1986-10-15 1988-04-21 Bayer Ag Neue metallsalze von 1-cyclopropyl-chinoloncarbonsaeuren und diese enthaltende arzneimittel
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
US5312088A (en) * 1993-03-17 1994-05-17 Universal Tool & Stamping Co., Inc. Screw designs for a scissors jack
ES2105970B1 (es) * 1995-08-02 1998-07-01 S A L V A T Lab Sa Composicion farmaceutica oral de ciprofloxacino, no acuosa, estable y con caracteristicas organolepticas mejoradas.
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
FI850632L (fi) 1985-08-18
IL74244A (en) 1988-06-30
NO162721C (no) 1990-02-07
PT79968B (en) 1987-02-02
NO850615L (no) 1985-08-19
KR900003512B1 (ko) 1990-05-21
PT79968A (en) 1985-03-01
ES540443A0 (es) 1986-04-16
IL74244A0 (en) 1985-05-31
EP0153828A3 (en) 1985-10-16
NZ211136A (en) 1988-08-30
HUT36805A (en) 1985-10-28
AR241593A1 (es) 1992-09-30
AU3856185A (en) 1985-08-22
HK71393A (en) 1993-07-30
PH21230A (en) 1987-08-21
AU566416B2 (en) 1987-10-22
DK165635B (da) 1992-12-28
IE58976B1 (en) 1993-12-15
DK165635C (da) 1993-06-01
OA07955A (en) 1987-01-31
GR850395B (es) 1985-06-14
KR850006415A (ko) 1985-10-05
DK67285A (da) 1985-08-18
CA1285279C (en) 1991-06-25
EP0153828A2 (en) 1985-09-04
DK67285D0 (da) 1985-02-13
DE3581090D1 (de) 1991-02-07
EP0153828B1 (en) 1990-12-27
SG56293G (en) 1993-07-09
NO162721B (no) 1989-10-30
IE850386L (en) 1985-08-17
HU193946B (en) 1987-12-28
FI850632A0 (fi) 1985-02-15

Similar Documents

Publication Publication Date Title
ES8606282A1 (es) Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
AU643489B2 (en) Antibacterial agents - II
NZ214610A (en) Piperazine derivatives and pharmaceutical compositions
HUT40101A (en) Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
MY105538A (en) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
AU586808B2 (en) Purine derivatives
IL86080A (en) Substituted alkoxy-2-alkyl-indan and 1,2,3,4-tetrahydro-naphthol,process for the preparation thereof and pharmaceutical compositions comprising the same
CA2016551A1 (en) Thieno-triazolo-diazepine derivatives, a preparation process of the same and therapeutic compositions containing them
AU7266291A (en) A novel substituted-amine compound and a process for the preparation thereof
ES8702390A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,5-benzotiazepina
AU5992990A (en) 14,17alpha-etheno- and -ethanoestratrienes, processes for the preparation of these compounds, as well as their use for the production of medicinal agents
MY106235A (en) New 2 - carbonyl substituted n, n'' -di (trimethoxybenzoyl) piperazines, process for preparing the same and therapeutical compounds containing them.
HUT45059A (en) Process for producing abeoergoline derivatives
HUT57227A (en) 2'-dezamino-4'-desoxy-4'-amino-8-fluoro-anthracycline derivatives, process for producing them as well as pharmaceutical preparatives containing said compounds as active substance
ES8203328A1 (es) Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas.
HUT35694A (en) Process for producing 2'-deoxy-oxanosine and pharmaceutical compositions containing them
IL106934A (en) Heteroarenylpiperazines a process for their preparation and pharmaceutical compositions comprising them
IE890199L (en) Antibiotic a 42867 derivative
ES8506700A1 (es) Un procedimiento para preparar nuevas 5-aminometil-imidazol-1-il-1,3-dialquil-1h-pirazol-4-il-aroil-metanonas
MY101746A (en) 1,5-benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof.
ES8606375A1 (es) Un procedimiento para preparar un derivado de aminoprpilaminobleomicina
ES8105713A1 (es) Un procedimiento para la preparacion de los enatiomeros levogiro y dextrogiro de la 1-ciclopropil-metil-4-(3-metoxi-5h- dibenzo (a,d) ciclohepten-5-iliden) piperidina