ES8203328A1 - Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas. - Google Patents

Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas.

Info

Publication number
ES8203328A1
ES8203328A1 ES496138A ES496138A ES8203328A1 ES 8203328 A1 ES8203328 A1 ES 8203328A1 ES 496138 A ES496138 A ES 496138A ES 496138 A ES496138 A ES 496138A ES 8203328 A1 ES8203328 A1 ES 8203328A1
Authority
ES
Spain
Prior art keywords
same
fluorodihydroxyphenylalanines
preparing
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496138A
Other languages
English (en)
Other versions
ES496138A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8203328A1 publication Critical patent/ES8203328A1/es
Publication of ES496138A0 publication Critical patent/ES496138A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE 6-FLUORDIHIDROXIFENILALANINAS. CONSISTE EN SOMETER A HIDROLISIS A UN COMPUESTO DE FORMULA GENERAL (I), CON LO QUE SE OBTIENE EL COMUESTO (II), EN QUE R ES HIDROGENO O METILO. ACTIVIDAD INHIBIDORA DE DESCARBOXILASA, TAL COMO LA INTERFERENCIA EN EL SISTEMA ENZIMATICO QUE EFECTUA LA DESCARBOXILACION DE UN ALFA-AMINOACIDO TAL COMO LA DOPA; LAS COMPOSICIONES SE FABRICAN UTILIZANDO PROCEDIMIENTOS PREPARATIVOS CONVENCIONALES Y PUEDEN CONTENER INDREDIENTES CONVENCIONALES TALES COMO DILUYENTES, VEHICULOS O EXCIPIENTES.
ES496138A 1979-10-22 1980-10-21 Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas. Granted ES496138A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8687179A 1979-10-22 1979-10-22
US15338880A 1980-05-27 1980-05-27

Publications (2)

Publication Number Publication Date
ES8203328A1 true ES8203328A1 (es) 1982-04-01
ES496138A0 ES496138A0 (es) 1982-04-01

Family

ID=26775247

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496138A Granted ES496138A0 (es) 1979-10-22 1980-10-21 Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas.

Country Status (6)

Country Link
EP (1) EP0027993A1 (es)
JP (1) JPS5665850A (es)
DK (1) DK444980A (es)
ES (1) ES496138A0 (es)
GR (1) GR70669B (es)
PT (1) PT71927B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0451422A1 (en) * 1990-04-13 1991-10-16 Merrell Dow Pharmaceuticals Inc. Pharmaceutically active fluoromethyltyrosine compounds
GB0115929D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL124121C (es) * 1960-04-08
US3725470A (en) * 1969-05-14 1973-04-03 Hoffmann La Roche Amino acid derivatives

Also Published As

Publication number Publication date
JPS5665850A (en) 1981-06-03
EP0027993A1 (en) 1981-05-06
DK444980A (da) 1981-04-23
PT71927A (en) 1980-11-01
PT71927B (en) 1982-03-31
GR70669B (es) 1982-12-06
ES496138A0 (es) 1982-04-01

Similar Documents

Publication Publication Date Title
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
PH23739A (en) Piperidine derivative and pharmaceutical composition
ES8300112A1 (es) Un procedimiento para preparar compuestos de cefem .
AU6128590A (en) Novel compounds
ES8203883A1 (es) Un procedimiento para la preparacion de derivados de imida- zol
ES8606282A1 (es) Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
MY100095A (en) 2-oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
IL75115A0 (en) Beta-carboline-3-oxadiazolyl derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
ES8106892A1 (es) Un procedimiento para preparar derivados de fenilpiperidina
PH24176A (en) New bicyclic compounds,process for preparation thereof and pharmaceutical composition comprising the same
ES8203382A1 (es) Un procedimiento para la preparacion de indolo benzoxazinas.
ES8203867A1 (es) Procedimiento para la obtencion de derivados de benzotiazol
HUT60275A (en) Process for producing 7-acyl-3-(substituted carbamoyloxy)-cef-3-em-4-carboxylic acid derivatives and pharmaceutical compositions comprising such compounds
ES8203328A1 (es) Un procedimiento para la preparacion de 6-fluordihidroxifenilalaninas.
ES474367A1 (es) Procedimiento de preparacion de nuevos derivados del benzo- (d)tiazol.
ES424274A1 (es) Procedimiento para la preparacion de 2,4-diamino-5-(3',5'- dimetoxi-4'-metoxialcoxibencil)-pirimidinas.
GB1109848A (en) New dibenzocycloheptadiene derivatives and process for their preparation
ES2018403A6 (es) Procedimiento para preparar nuevas 2-carbonil sustituido-n, n' -di(trimetoxibenzoil) -piperazinas.
DE2962281D1 (en) Substituted 2-phenylamino-3,4,5,6-tetrahydropyrimidines, their acid addition salts, medicines containing them and process for their preparation
ES470462A1 (es) Procedimiento para producir imidazol-2-carbamatos
ES8507524A1 (es) Un procedimiento para preparar derivados de tropona
SE8903313L (sv) Nya 2-metoxikarbonyl-substituerade n,n'-di-(trimetoxibensoyl)-piperaziner, foerfarande foer framstaellning daerav och terapeutiska foereningar innehaallande dem
GB1420758A (en) Anti-ulcer compositions
ES306443A1 (es) Procedimiento de preparaciën de derivados de quinoleina
ES484086A1 (es) Procedimiento para la preparacion de compuestos de isopropi-lamina