ES2018403A6 - Procedimiento para preparar nuevas 2-carbonil sustituido-n, n' -di(trimetoxibenzoil) -piperazinas. - Google Patents

Procedimiento para preparar nuevas 2-carbonil sustituido-n, n' -di(trimetoxibenzoil) -piperazinas.

Info

Publication number
ES2018403A6
ES2018403A6 ES8903410A ES8903410A ES2018403A6 ES 2018403 A6 ES2018403 A6 ES 2018403A6 ES 8903410 A ES8903410 A ES 8903410A ES 8903410 A ES8903410 A ES 8903410A ES 2018403 A6 ES2018403 A6 ES 2018403A6
Authority
ES
Spain
Prior art keywords
trimethoxygenzoyl
piperazines
preparing
same
compounds containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8903410A
Other languages
English (en)
Inventor
Eduardo Pirotsky
Georges Dive
Jean-Jacques Godfroid
Francoise Heymans
Pierre Braquet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES2018403A6 publication Critical patent/ES2018403A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVAS 2-CARBONIL SUSTITUIDO-N,N''-DI-(TRIMETOXIBENZOIL)-PIPERAZINAS DE FORMULA FORMULA DONDE Y ES FORMULA Y Z ES OA (SIENDO A UNA CADENA ALQUILICA LINEAL O RAMIFICADA), UN GRUPO CICLOALQUILO O UN GRUPO DE FORMULA FORMULA DONDE N ES 0-5 Y RSI1-RSI5 REPRESENTAN HIDROGENO, CLORO, BROMO O UN GRUPO ORGANICO. COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA FORMULA DONDE Z ES COMO ANTES, CON N,N''-DIBENCILETILIDENDIAMINA EN UN DISOLVENTE APROTICO, A 80GC, EN PRESENCIA DE TRIETILAMINA, HIDROGENOLIZAR LA PIPERAZINA TRISUSTITUIDA OBTENIDA EN PRESENCIA DE PD/CARBON VEGETAL EN UN DISOLVENTE ALCOHOLICO A 40GC Y A PRESION, Y TRATAR LA CORRESPONDIENTE PIPERAZINA MONOSUSTITUIDA OBTENIDA CON CLORURO DE 3,4,5-TRIMETOXIBENZOILO EN BENCENO Y EN PRESENCIA DE TRIETILAMINA, A TEMPERATURA AMBIENTE. LOS COMPUESTOS OBTENIDOS SON UTILES COMO INHIBIDORES DE LA AGREGACION PLAQUETARIA.
ES8903410A 1988-10-11 1989-10-10 Procedimiento para preparar nuevas 2-carbonil sustituido-n, n' -di(trimetoxibenzoil) -piperazinas. Expired - Fee Related ES2018403A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888823775A GB8823775D0 (en) 1988-10-11 1988-10-11 New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines

Publications (1)

Publication Number Publication Date
ES2018403A6 true ES2018403A6 (es) 1991-04-01

Family

ID=10644988

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903410A Expired - Fee Related ES2018403A6 (es) 1988-10-11 1989-10-10 Procedimiento para preparar nuevas 2-carbonil sustituido-n, n' -di(trimetoxibenzoil) -piperazinas.

Country Status (33)

Country Link
US (1) US4923870A (es)
JP (1) JPH0635452B2 (es)
KR (1) KR970004912B1 (es)
AR (1) AR245110A1 (es)
AT (1) AT395423B (es)
AU (1) AU618220B2 (es)
BE (1) BE1003519A3 (es)
CA (1) CA1320958C (es)
CH (1) CH679859A5 (es)
DE (1) DE3933881C2 (es)
DK (1) DK500389A (es)
DZ (1) DZ1365A1 (es)
ES (1) ES2018403A6 (es)
FI (1) FI96854C (es)
FR (2) FR2637500B1 (es)
GB (2) GB8823775D0 (es)
GR (1) GR1000343B (es)
HK (1) HK47592A (es)
IE (1) IE62011B1 (es)
IN (1) IN173325B (es)
IT (1) IT1237088B (es)
LU (1) LU87604A1 (es)
MA (1) MA21652A1 (es)
MY (1) MY106235A (es)
NL (1) NL8902520A (es)
NO (1) NO176180C (es)
NZ (1) NZ230927A (es)
OA (1) OA09139A (es)
PT (1) PT91941B (es)
SE (1) SE505239C2 (es)
SG (1) SG41292G (es)
TN (1) TNSN89110A1 (es)
ZA (1) ZA897554B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
GB8908587D0 (en) * 1989-04-15 1989-06-01 Scras Societe De Conseils De R New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
WO1992020661A1 (en) * 1991-05-22 1992-11-26 Merck & Co., Inc. N, n-diacylpiperazines
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
US5348955A (en) * 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
FR2780649B1 (fr) 1998-07-06 2001-03-09 Univ Paris Vii Denis Diderot Derives de la piperazine pour l'inhibition de la replication du virus de l'immunodeficience humaine

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3186993A (en) * 1962-06-07 1965-06-01 Ethyl Corp alpha, alpha'-(1, 4-piperazinediyl) bis (3, 5-dialkyl-4-hydroxythiobenzaldehyde) compounds
GB1243991A (en) * 1968-06-10 1971-08-25 Ici Ltd Piperidine, morpholine and piperazine derivatives
FR2209560A1 (en) * 1972-12-07 1974-07-05 Degussa N-(Trialkoxyaroyl)-ethylenediamine derivs - useful as cardioactive medicaments, exhibit anti-ischaemic activity comparable to nitroglycerin
DE2423847A1 (de) * 1973-05-28 1975-01-02 Ciba Geigy Ag Neue sulfamoylbenzoesaeureamide
GB8427735D0 (en) * 1984-11-02 1984-12-12 Fujisawa Pharmaceutical Co Piperazine compound
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
DE3636278A1 (de) * 1986-10-24 1988-05-05 Hoechst Ag Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
IL85700A0 (en) * 1987-03-24 1988-08-31 Takeda Chemical Industries Ltd 1,4-disubstituted piperazine compounds,their production and use
GB8823776D0 (en) * 1988-10-11 1988-11-16 Scras New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
SG41292G (en) 1992-06-12
TNSN89110A1 (fr) 1991-02-04
GB8823775D0 (en) 1988-11-16
FI894812A0 (fi) 1989-10-11
FR2637500A1 (fr) 1990-04-13
AT395423B (de) 1992-12-28
GR890100647A (en) 1990-11-29
NO176180B (no) 1994-11-07
JPH0635452B2 (ja) 1994-05-11
GB8922870D0 (en) 1989-11-29
CA1320958C (en) 1993-08-03
CH679859A5 (es) 1992-04-30
NO894038D0 (no) 1989-10-10
IT8921992A1 (it) 1991-04-11
SE8903312L (sv) 1990-04-12
DK500389D0 (da) 1989-10-10
NZ230927A (en) 1991-01-29
FI96854C (fi) 1996-09-10
FR2637500B1 (fr) 1992-06-05
GR1000343B (el) 1992-06-25
DK500389A (da) 1990-04-12
IT8921992A0 (it) 1989-10-11
GB2223753A (en) 1990-04-18
NO894038L (no) 1990-04-17
SE8903312D0 (sv) 1989-10-09
NL8902520A (nl) 1990-05-01
KR970004912B1 (ko) 1997-04-08
FI894812A (fi) 1990-04-12
PT91941A (pt) 1990-04-30
BE1003519A3 (fr) 1992-04-14
HK47592A (en) 1992-07-10
OA09139A (fr) 1991-10-31
MY106235A (en) 1995-04-29
LU87604A1 (fr) 1990-02-07
AU4268889A (en) 1990-04-26
AR245110A1 (es) 1993-12-30
DZ1365A1 (fr) 2004-09-13
IE62011B1 (en) 1994-12-14
GB2223753B (en) 1992-01-02
FR2637593A1 (fr) 1990-04-13
US4923870A (en) 1990-05-08
NO176180C (no) 1995-02-15
DE3933881A1 (de) 1990-04-12
IE893258L (en) 1990-04-11
IT1237088B (it) 1993-05-18
FI96854B (fi) 1996-05-31
SE505239C2 (sv) 1997-07-21
MA21652A1 (fr) 1990-07-01
ATA234689A (de) 1992-05-15
IN173325B (es) 1994-04-02
PT91941B (pt) 1995-05-31
DE3933881C2 (de) 1994-06-30
KR900006309A (ko) 1990-05-07
ZA897554B (en) 1990-07-25
AU618220B2 (en) 1991-12-12
JPH02223565A (ja) 1990-09-05
FR2637593B1 (fr) 1992-06-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041011