ES2184770T3 - Guanididas de acido alquil-carboxilico sustituidas con fenilo y portadoras de grupos pperfluoralquilo, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como medicamentos que las contienen. - Google Patents

Guanididas de acido alquil-carboxilico sustituidas con fenilo y portadoras de grupos pperfluoralquilo, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como medicamentos que las contienen.

Info

Publication number
ES2184770T3
ES2184770T3 ES95100675T ES95100675T ES2184770T3 ES 2184770 T3 ES2184770 T3 ES 2184770T3 ES 95100675 T ES95100675 T ES 95100675T ES 95100675 T ES95100675 T ES 95100675T ES 2184770 T3 ES2184770 T3 ES 2184770T3
Authority
ES
Spain
Prior art keywords
rent
equal
perfluor
well
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95100675T
Other languages
English (en)
Inventor
Jan-Robert Dr Schwark
Heinz-Werner Dr Kleemann
Hans-Jochen Dr Lang
Andreas Dr Weichert
Wolfgang Dr Scholz
Udo Dr Albus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4402057A external-priority patent/DE4402057A1/de
Priority claimed from DE4413615A external-priority patent/DE4413615A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2184770T3 publication Critical patent/ES2184770T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Dentistry (AREA)
  • Pathology (AREA)
  • Environmental Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBEN COMPUESTOS GUANIDINA ACIDO CARBOXILICO ALQUIL FENIL SUSTITUIDO QUE PORTA GRUPOS PERFLUOR ALQUIL DE LA FORMULA I CON RA) Y R(B) IGUAL A H, HAL, CN, OR(6), ALQUIL, O R - PERFLUOR ALQUIL, NR(7)R(8); R(6) IGUAL A HIDROGENO, (CICLO) ALQ(EN)IL, PERFLUOR ALQUIL, FENIL, BENCIL; R(7) Y R(8) SE DEFINEN COMO R(6); X IGUAL A 1 - 3; R(1) IGUAL A H, ALQUIL, - O0 - 1 ( CH2)0 - 1 PERFLUOR ALQUIL; R(2), R(3), R(4) Y R(5) SE DEFINEN COMO R(1), SIN EMBARGO BAJO LA CONDICION, DE QUE R(1), R(2), R(3), R(4) Y R(5) NO SON IGUALES A HIDROGENO, Y QUE R(1), R(2), R(3), R(4) Y R(5) PUEDEN SER ENTONCES SOLAMENTE ALQUIL, CUANDO AL MENOS UNO DE LOS SUSTITUYENTES R(A) O R(B) CONTIENEN UN GRUPO OR(CH2)ACBF2B+1; ASI COMO SUS SALES TOLERABLES FARMACEUTICAMENTE. SE OBTIENEN LOS COMPUESTOS I MEDIANTE TRANSFORMACION DE UN COMPUESTO II CON GUANIDINA, DONDE L ES UN GRUPO SUSTITUIBLE NUCLEOFILO LIGERO. LOS COMPUESTOS I SON INHIBIDORES DE ANTIPORTADORES SODIO PROTONES CELULARES (NA+H+ -EXCHANGER). SON APROPIADOS PARATERAPIA PREVENTIVA, A FIN DE PREVENIR LA GENESIS DE ALTA PRESION ARTERIAL, POR EJEMPLO DE HIPERTONIAS ESENCIALES.
ES95100675T 1994-01-25 1995-01-19 Guanididas de acido alquil-carboxilico sustituidas con fenilo y portadoras de grupos pperfluoralquilo, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como medicamentos que las contienen. Expired - Lifetime ES2184770T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4402057A DE4402057A1 (de) 1994-01-25 1994-01-25 Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4413615A DE4413615A1 (de) 1994-04-19 1994-04-19 Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
ES2184770T3 true ES2184770T3 (es) 2003-04-16

Family

ID=25933249

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95100675T Expired - Lifetime ES2184770T3 (es) 1994-01-25 1995-01-19 Guanididas de acido alquil-carboxilico sustituidas con fenilo y portadoras de grupos pperfluoralquilo, procedimiento para su preparacion, su uso como medicamento o agente de diagnostico asi como medicamentos que las contienen.

Country Status (15)

Country Link
US (1) US5567734A (es)
EP (1) EP0666252B1 (es)
JP (1) JP3718250B2 (es)
AT (1) ATE225332T1 (es)
AU (1) AU683328B2 (es)
CA (1) CA2140989C (es)
DE (1) DE59510395D1 (es)
DK (1) DK0666252T3 (es)
ES (1) ES2184770T3 (es)
FI (1) FI950305L (es)
HU (1) HU217617B (es)
NO (1) NO302231B1 (es)
NZ (1) NZ270370A (es)
PT (1) PT666252E (es)
TW (1) TW415937B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0765867A1 (de) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament
DE19540995A1 (de) * 1995-11-03 1997-05-07 Hoechst Ag Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19542306A1 (de) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19605610A1 (de) * 1996-02-15 1997-08-21 Hoechst Ag Substituierte Thiophenylalkenylcarbonsäureguanidide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US6429481B1 (en) * 1997-11-14 2002-08-06 Fairchild Semiconductor Corporation Field effect transistor and method of its manufacture
AU3078500A (en) * 1999-01-27 2000-08-18 Sumitomo Pharmaceuticals Company, Limited Novel substituted guanidine derivatives and process for the preparation thereof
NZ544671A (en) * 2003-06-26 2009-02-28 Biotron Ltd Antiviral compounds and methods
US20070099968A1 (en) * 2004-06-26 2007-05-03 Biotron Limited Antiviral compounds and methods
TW200808705A (en) * 2006-06-15 2008-02-16 Sanofi Aventis Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3780027A (en) * 1970-04-29 1973-12-18 Merck & Co Inc Anthranilic acid derivatives
DE2931735A1 (de) * 1979-08-04 1981-02-19 Beiersdorf Ag Neue substituierte phenylacetylguanidine und verfahren zu ihrer herstellung
DE3360148D1 (en) * 1982-02-10 1985-06-05 Beecham Group Plc Guanidine derivatives
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
CZ284456B6 (cs) * 1992-02-15 1998-12-16 Hoechst Aktiengesellschaft Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DE4318658A1 (de) * 1993-06-04 1994-12-08 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
FI950305A0 (fi) 1995-01-24
HU9500211D0 (en) 1995-05-29
HUT71413A (en) 1995-11-28
TW415937B (en) 2000-12-21
AU683328B2 (en) 1997-11-06
NO950258D0 (no) 1995-01-24
NZ270370A (en) 1995-09-26
DE59510395D1 (de) 2002-11-07
CA2140989A1 (en) 1995-07-26
CA2140989C (en) 2006-09-19
JPH07224022A (ja) 1995-08-22
PT666252E (pt) 2003-02-28
HU217617B (hu) 2000-03-28
DK0666252T3 (da) 2003-01-27
ATE225332T1 (de) 2002-10-15
AU1135395A (en) 1995-08-03
NO950258L (no) 1995-07-26
EP0666252B1 (de) 2002-10-02
NO302231B1 (no) 1998-02-09
JP3718250B2 (ja) 2005-11-24
US5567734A (en) 1996-10-22
FI950305A7 (fi) 1995-07-26
EP0666252A1 (de) 1995-08-09
FI950305L (fi) 1995-07-26

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