ES8801651A1 - Un procedimiento para preparar fenixialquil(substituido con heterociclo)-isozazoles y furanos - Google Patents
Un procedimiento para preparar fenixialquil(substituido con heterociclo)-isozazoles y furanosInfo
- Publication number
- ES8801651A1 ES8801651A1 ES557780A ES557780A ES8801651A1 ES 8801651 A1 ES8801651 A1 ES 8801651A1 ES 557780 A ES557780 A ES 557780A ES 557780 A ES557780 A ES 557780A ES 8801651 A1 ES8801651 A1 ES 8801651A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- phenoxyalkyl
- isoxazoles
- furans
- antiviral agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE FENOXIALQUIL(SUSTITUIDO CON HETEROCICLO)-ISOXAZOLES Y -FURANOS, Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II), CON AZIDURO DE SODIO, PARA LA OBTENCION DE UN TETRAZOL, EN EL QUE R3 ES HIDROGENO, Y, SI SE DESEA, SE TRATA DE DICHO TETRAZOL CON UN HALOGENURO DE ALQUILO INFERIOR, EN PRESENCIA DE UNA BASE, PARA OBTENER TERAZOLES ISOMEROS, EN LOS QYE R3 ES ALQUILO INFERIOR. DE APLICACION EN MEDICINA Y FARMACIA COMO AGENTES ANTIVIRALES EFECTIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75134885A | 1985-07-02 | 1985-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8801651A1 true ES8801651A1 (es) | 1988-02-16 |
| ES557780A0 ES557780A0 (es) | 1988-02-16 |
Family
ID=25021592
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556812A Expired ES8802518A1 (es) | 1985-07-02 | 1986-06-25 | Un procedimiento para preparar derivados de isoxazol y furano. |
| ES556811A Expired ES8802517A1 (es) | 1985-07-02 | 1986-06-25 | Un procedimiento para preparar fenoxialquil (substituido con heterocido)-isoxazoles y furanos. |
| ES557778A Expired ES8802153A1 (es) | 1985-07-02 | 1987-12-04 | Procedimiento para preparar derivados de isoxazol y furano. |
| ES557780A Expired ES8801651A1 (es) | 1985-07-02 | 1987-12-07 | Un procedimiento para preparar fenixialquil(substituido con heterociclo)-isozazoles y furanos |
| ES557779A Expired ES8801649A1 (es) | 1985-07-02 | 1987-12-07 | Un procedimiento para preparar fenixialquil(substituido con heterociclo)-isoxazoles y furanos |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556812A Expired ES8802518A1 (es) | 1985-07-02 | 1986-06-25 | Un procedimiento para preparar derivados de isoxazol y furano. |
| ES556811A Expired ES8802517A1 (es) | 1985-07-02 | 1986-06-25 | Un procedimiento para preparar fenoxialquil (substituido con heterocido)-isoxazoles y furanos. |
| ES557778A Expired ES8802153A1 (es) | 1985-07-02 | 1987-12-04 | Procedimiento para preparar derivados de isoxazol y furano. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES557779A Expired ES8801649A1 (es) | 1985-07-02 | 1987-12-07 | Un procedimiento para preparar fenixialquil(substituido con heterociclo)-isoxazoles y furanos |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP0207454B1 (es) |
| JP (2) | JPH0768242B2 (es) |
| KR (2) | KR900001314B1 (es) |
| AR (4) | AR241705A1 (es) |
| AT (2) | ATE80397T1 (es) |
| AU (2) | AU587622B2 (es) |
| CA (2) | CA1299176C (es) |
| DE (3) | DE3689924D1 (es) |
| DK (2) | DK171275B1 (es) |
| ES (5) | ES8802518A1 (es) |
| FI (2) | FI85021C (es) |
| GR (2) | GR861697B (es) |
| IE (2) | IE66234B1 (es) |
| IL (2) | IL79309A (es) |
| MX (4) | MX2954A (es) |
| MY (1) | MY102908A (es) |
| NO (2) | NO164977C (es) |
| NZ (1) | NZ216678A (es) |
| PH (2) | PH22321A (es) |
| PT (2) | PT82892B (es) |
| ZA (2) | ZA864873B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1299176C (en) * | 1985-07-02 | 1992-04-21 | Guy Dominic Diana | Process for preparing isoxazole and furan derivatives |
| IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
| US5051437A (en) * | 1986-06-24 | 1991-09-24 | Sterling Drug Inc. | Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents |
| GB8807275D0 (en) * | 1988-03-26 | 1988-04-27 | Synphar Lab Inc | Chemical compounds |
| ZA896668B (en) * | 1988-09-01 | 1990-06-27 | Molecular Therapeutics Inc | A human rhinovirus receptor protein that inhibits virus infectivity |
| US6514936B1 (en) | 1988-09-01 | 2003-02-04 | Bayer Corporation | Antiviral methods using human rhinovirus receptor (ICAM-1) |
| US6051231A (en) * | 1988-09-01 | 2000-04-18 | Bayer Corporation | Antiviral methods and prepations |
| US6143298A (en) * | 1988-09-01 | 2000-11-07 | Bayer Corporation | Soluble truncated forms of ICAM-1 |
| ES2141076T3 (es) | 1988-09-01 | 2000-03-16 | Bayer Ag | Proteina del receptor de rinovirus humano que inhibe la infectividad del virus. |
| GB8911158D0 (en) * | 1989-05-16 | 1989-07-05 | Janssen Pharmaceutica Nv | Antiviral pyridazinamines |
| US5070090A (en) * | 1989-05-15 | 1991-12-03 | Janssen Pharmaceutica N.V. | Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers |
| US4945164A (en) * | 1989-08-18 | 1990-07-31 | Sterling Drug Inc. | 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof |
| US4942241A (en) * | 1989-08-21 | 1990-07-17 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| NZ234760A (en) * | 1989-08-18 | 1991-09-25 | Sterling Drug Inc | Antiviral oxazole compounds and compositions |
| US5175178A (en) * | 1989-08-21 | 1992-12-29 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5110821A (en) * | 1989-08-18 | 1992-05-05 | Sterling Drug Inc. | 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5686582A (en) * | 1990-07-20 | 1997-11-11 | Bayer Corporation | Multimeric forms of human rhinovirus receptor protein |
| US6107461A (en) * | 1990-07-20 | 2000-08-22 | Bayer Corporation | Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use |
| EP0468257B1 (en) * | 1990-07-20 | 1999-09-01 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
| US5686581A (en) * | 1990-07-20 | 1997-11-11 | Bayer Corporation | Multimeric form of human rhinovirus receptor protein |
| IT1247509B (it) * | 1991-04-19 | 1994-12-17 | Univ Cagliari | Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus |
| US5175177A (en) * | 1991-07-17 | 1992-12-29 | Sterling Drug Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5349068A (en) * | 1992-04-15 | 1994-09-20 | Sterling Winthrop Inc. | 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents |
| US5514781A (en) * | 1994-04-11 | 1996-05-07 | Bayer Corporation | Use of azoles as virucidal agents in solutions of biologically active proteins |
| US5514679A (en) * | 1994-05-13 | 1996-05-07 | Sterling Winthrop Inc. | Therapeutic phenoxyalklpyridazines and intermediates therefor |
| US5453433A (en) * | 1994-05-13 | 1995-09-26 | Sterling Winthrop Inc. | Thiadiazoles and antipicornaviral compositions |
| WO2005005423A1 (en) | 2003-07-02 | 2005-01-20 | F. Hoffmann-La Roche Ag | Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators |
| WO2006103045A1 (en) | 2005-03-31 | 2006-10-05 | Ucb Pharma S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| KR20120049852A (ko) * | 2009-06-30 | 2012-05-17 | 시가 테크놀로지스, 인크. | 뎅기 바이러스 감염의 치료 및 예방 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4451476A (en) * | 1982-12-13 | 1984-05-29 | Sterling Drug Inc. | Isoxazoles as antiviral agents |
| NZ209209A (en) * | 1983-08-29 | 1988-02-12 | Sterling Drug Inc | Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions |
| CA1299176C (en) * | 1985-07-02 | 1992-04-21 | Guy Dominic Diana | Process for preparing isoxazole and furan derivatives |
-
1986
- 1986-06-24 CA CA000512264A patent/CA1299176C/en not_active Expired - Lifetime
- 1986-06-24 CA CA000512258A patent/CA1280753C/en not_active Expired - Lifetime
- 1986-06-25 ES ES556812A patent/ES8802518A1/es not_active Expired
- 1986-06-25 ES ES556811A patent/ES8802517A1/es not_active Expired
- 1986-06-25 PH PH33948A patent/PH22321A/en unknown
- 1986-06-25 PH PH33947A patent/PH23197A/en unknown
- 1986-06-26 NZ NZ216678A patent/NZ216678A/xx unknown
- 1986-06-26 DE DE3689924A patent/DE3689924D1/de not_active Expired - Fee Related
- 1986-06-26 DE DE8686108745T patent/DE3686677T2/de not_active Expired - Fee Related
- 1986-06-26 AT AT86108745T patent/ATE80397T1/de not_active IP Right Cessation
- 1986-06-26 IE IE172386A patent/IE66234B1/en not_active IP Right Cessation
- 1986-06-26 DE DE3689924T patent/DE3689924T4/de not_active Expired - Lifetime
- 1986-06-26 IE IE172486A patent/IE59755B1/en not_active IP Right Cessation
- 1986-06-26 EP EP86108745A patent/EP0207454B1/en not_active Expired - Lifetime
- 1986-06-26 AT AT86108744T patent/ATE107645T1/de not_active IP Right Cessation
- 1986-06-26 EP EP86108744A patent/EP0207453B1/en not_active Expired - Lifetime
- 1986-06-27 MX MX295486A patent/MX2954A/es unknown
- 1986-06-30 GR GR861697A patent/GR861697B/el unknown
- 1986-06-30 GR GR861695A patent/GR861695B/el unknown
- 1986-07-01 PT PT82892A patent/PT82892B/pt active IP Right Grant
- 1986-07-01 FI FI862794A patent/FI85021C/fi not_active IP Right Cessation
- 1986-07-01 IL IL79309A patent/IL79309A/xx not_active IP Right Cessation
- 1986-07-01 PT PT82891A patent/PT82891B/pt not_active IP Right Cessation
- 1986-07-01 NO NO862651A patent/NO164977C/no not_active IP Right Cessation
- 1986-07-01 NO NO862650A patent/NO165023C/no not_active IP Right Cessation
- 1986-07-01 ZA ZA864873A patent/ZA864873B/xx unknown
- 1986-07-01 DK DK312986A patent/DK171275B1/da not_active IP Right Cessation
- 1986-07-01 AU AU59456/86A patent/AU587622B2/en not_active Ceased
- 1986-07-01 KR KR1019860005307A patent/KR900001314B1/ko not_active IP Right Cessation
- 1986-07-01 ZA ZA864872A patent/ZA864872B/xx unknown
- 1986-07-01 IL IL79308A patent/IL79308A/xx not_active IP Right Cessation
- 1986-07-01 KR KR1019860005308A patent/KR900001315B1/ko not_active IP Right Cessation
- 1986-07-01 AU AU59457/86A patent/AU589190B2/en not_active Ceased
- 1986-07-01 DK DK198603130A patent/DK173467B1/da not_active IP Right Cessation
- 1986-07-01 FI FI862795A patent/FI862795A/fi not_active Application Discontinuation
- 1986-07-02 JP JP61155928A patent/JPH0768242B2/ja not_active Expired - Fee Related
- 1986-07-02 JP JP61155927A patent/JPH0819128B2/ja not_active Expired - Fee Related
- 1986-07-02 AR AR86304418A patent/AR241705A1/es active
-
1987
- 1987-09-28 MY MYPI87002033A patent/MY102908A/en unknown
- 1987-12-04 ES ES557778A patent/ES8802153A1/es not_active Expired
- 1987-12-07 ES ES557780A patent/ES8801651A1/es not_active Expired
- 1987-12-07 ES ES557779A patent/ES8801649A1/es not_active Expired
-
1990
- 1990-03-07 AR AR90316339A patent/AR242572A1/es active
- 1990-03-28 AR AR90316484A patent/AR242573A1/es active
- 1990-03-28 AR AR90316483A patent/AR244686A1/es active
-
1991
- 1991-06-28 MX MX9100032A patent/MX9100032A/es unknown
- 1991-06-28 MX MX9100033A patent/MX9100033A/es unknown
- 1991-06-28 MX MX9100029A patent/MX9100029A/es unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC2A | Transfer of patent |
Owner name: STERLING WINTHROP INC. |
|
| PC1A | Transfer granted | ||
| FD1A | Patent lapsed |
Effective date: 20041224 |