DE3689924T4 - Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel. - Google Patents

Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.

Info

Publication number
DE3689924T4
DE3689924T4 DE3689924T DE3689924T DE3689924T4 DE 3689924 T4 DE3689924 T4 DE 3689924T4 DE 3689924 T DE3689924 T DE 3689924T DE 3689924 T DE3689924 T DE 3689924T DE 3689924 T4 DE3689924 T4 DE 3689924T4
Authority
DE
Germany
Prior art keywords
phenoxyalkylisoxazoles
substituted
heterocyclic group
antiviral agents
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3689924T
Other languages
English (en)
Other versions
DE3689924T2 (de
DE3689924D1 (de
Inventor
Guy Dominic Diana
Philip Michael Carabateas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of DE3689924T2 publication Critical patent/DE3689924T2/de
Application granted granted Critical
Publication of DE3689924T4 publication Critical patent/DE3689924T4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
DE3689924T 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel. Expired - Lifetime DE3689924T4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75134885A 1985-07-02 1985-07-02

Publications (2)

Publication Number Publication Date
DE3689924T2 DE3689924T2 (de) 1995-01-19
DE3689924T4 true DE3689924T4 (de) 1995-05-11

Family

ID=25021592

Family Applications (3)

Application Number Title Priority Date Filing Date
DE8686108745T Expired - Fee Related DE3686677T2 (de) 1985-07-02 1986-06-26 Isoxazol- und furanderivate, verfahren zu ihrer herstellung und ihre verwendung als antivirale mittel.
DE3689924A Expired - Fee Related DE3689924D1 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.
DE3689924T Expired - Lifetime DE3689924T4 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE8686108745T Expired - Fee Related DE3686677T2 (de) 1985-07-02 1986-06-26 Isoxazol- und furanderivate, verfahren zu ihrer herstellung und ihre verwendung als antivirale mittel.
DE3689924A Expired - Fee Related DE3689924D1 (de) 1985-07-02 1986-06-26 Durch eine heterocyclische Gruppe substituierte Phenoxyalkylisoxazole und ihre Verwendung als antivirale Mittel.

Country Status (21)

Country Link
EP (2) EP0207454B1 (de)
JP (2) JPH0819128B2 (de)
KR (2) KR900001314B1 (de)
AR (4) AR241705A1 (de)
AT (2) ATE80397T1 (de)
AU (2) AU589190B2 (de)
CA (2) CA1280753C (de)
DE (3) DE3686677T2 (de)
DK (2) DK173467B1 (de)
ES (5) ES8802517A1 (de)
FI (2) FI862795A (de)
GR (2) GR861695B (de)
IE (2) IE59755B1 (de)
IL (2) IL79309A (de)
MX (4) MX2954A (de)
MY (1) MY102908A (de)
NO (2) NO165023C (de)
NZ (1) NZ216678A (de)
PH (2) PH23197A (de)
PT (2) PT82891B (de)
ZA (2) ZA864873B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US5051437A (en) * 1986-06-24 1991-09-24 Sterling Drug Inc. Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
GB8807275D0 (en) * 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
US6051231A (en) * 1988-09-01 2000-04-18 Bayer Corporation Antiviral methods and prepations
EP0362531B1 (de) 1988-09-01 1999-11-10 Bayer Corporation Menschliches Rhinovirusrezeptorprotein, das die Virusinfektionsanfälligkeit hemmt
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
US6514936B1 (en) 1988-09-01 2003-02-04 Bayer Corporation Antiviral methods using human rhinovirus receptor (ICAM-1)
US5070090A (en) * 1989-05-15 1991-12-03 Janssen Pharmaceutica N.V. Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) * 1989-05-16 1989-07-05 Janssen Pharmaceutica Nv Antiviral pyridazinamines
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5110821A (en) * 1989-08-18 1992-05-05 Sterling Drug Inc. 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US5871733A (en) * 1990-07-20 1999-02-16 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
ES2134762T3 (es) * 1990-07-20 1999-10-16 Bayer Ag Formas multimericas de proteinas receptoras de rinovirus humanos.
IT1247509B (it) * 1991-04-19 1994-12-17 Univ Cagliari Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5514781A (en) * 1994-04-11 1996-05-07 Bayer Corporation Use of azoles as virucidal agents in solutions of biologically active proteins
US5514679A (en) * 1994-05-13 1996-05-07 Sterling Winthrop Inc. Therapeutic phenoxyalklpyridazines and intermediates therefor
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
KR100796093B1 (ko) 2003-07-02 2008-01-21 에프. 호프만-라 로슈 아게 티아졸 고리로 치환된 인돌릴 유도체 및 ｐｐａｒ조절제로서 그의 용도
EP1866293A1 (de) 2005-03-31 2007-12-19 UCB Pharma, S.A. Eine oxazol- oder thiazolgruppe enthaltende verbindungen, verfahren zu deren herstellung und ihre anwendungen
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
EP2448410A4 (de) * 2009-06-30 2013-12-18 Siga Technologies Inc Behandlung und vorbeugung von infektionen mit dem dengue-virus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
NZ209209A (en) * 1983-08-29 1988-02-12 Sterling Drug Inc Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans

Also Published As

Publication number Publication date
DE3689924T2 (de) 1995-01-19
JPH0768242B2 (ja) 1995-07-26
IL79308A0 (en) 1986-10-31
EP0207453A3 (en) 1988-11-23
EP0207453B1 (de) 1994-06-22
NO164977B (no) 1990-08-27
IE59755B1 (en) 1994-03-23
IL79308A (en) 1991-01-31
ATE80397T1 (de) 1992-09-15
DK313086A (da) 1987-01-03
DK312986A (da) 1987-01-03
EP0207453A2 (de) 1987-01-07
ES8801651A1 (es) 1988-02-16
DK313086D0 (da) 1986-07-01
KR870001202A (ko) 1987-03-12
IE66234B1 (en) 1995-12-13
NO862650D0 (no) 1986-07-01
KR900001315B1 (ko) 1990-03-08
IE861723L (en) 1987-01-02
KR870001205A (ko) 1987-03-12
EP0207454B1 (de) 1992-09-09
MX9100033A (es) 1993-01-01
JPH0819128B2 (ja) 1996-02-28
ES8802518A1 (es) 1988-07-01
DE3686677D1 (de) 1992-10-15
FI85021C (fi) 1992-02-25
IL79309A0 (en) 1986-10-31
PT82892B (pt) 1994-09-30
CA1299176C (en) 1992-04-21
IE861724L (en) 1987-01-02
ES557780A0 (es) 1988-02-16
ES556811A0 (es) 1988-07-01
IL79309A (en) 1990-11-29
EP0207454A3 (en) 1988-08-10
AU589190B2 (en) 1989-10-05
ATE107645T1 (de) 1994-07-15
FI862794A (fi) 1987-01-03
AR241705A1 (es) 1992-11-30
AU587622B2 (en) 1989-08-24
ZA864873B (en) 1987-02-25
DK171275B1 (da) 1996-08-19
ES556812A0 (es) 1988-07-01
FI862795A (fi) 1987-01-03
MY102908A (en) 1993-03-31
ES557778A0 (es) 1988-04-01
DE3689924D1 (de) 1994-07-28
MX9100029A (es) 1993-01-01
JPS6216480A (ja) 1987-01-24
GR861695B (en) 1986-11-04
MX9100032A (es) 1993-01-01
AU5945786A (en) 1987-01-08
FI85021B (fi) 1991-11-15
GR861697B (en) 1986-11-04
PH23197A (en) 1989-05-29
PT82891B (pt) 1988-05-27
AR244686A1 (es) 1993-11-30
NO862650L (no) 1987-01-05
PT82891A (en) 1986-08-01
ES8802517A1 (es) 1988-07-01
NO862651D0 (no) 1986-07-01
PT82892A (pt) 1987-01-26
AU5945686A (en) 1987-01-08
NO165023B (no) 1990-09-03
DE3686677T2 (de) 1993-03-11
KR900001314B1 (ko) 1990-03-08
PH22321A (en) 1988-07-29
EP0207454A2 (de) 1987-01-07
NZ216678A (en) 1989-10-27
MX2954A (es) 1993-11-01
NO165023C (no) 1990-12-12
AR242573A1 (es) 1993-04-30
ES8801649A1 (es) 1988-02-16
ZA864872B (en) 1987-02-25
CA1280753C (en) 1991-02-26
NO164977C (no) 1990-12-05
AR242572A1 (es) 1993-04-30
DK312986D0 (da) 1986-07-01
FI862795A0 (fi) 1986-07-01
JPS6216479A (ja) 1987-01-24
ES8802153A1 (es) 1988-04-01
FI862794A0 (fi) 1986-07-01
DK173467B1 (da) 2000-12-04
NO862651L (no) 1987-01-05
ES557779A0 (es) 1988-02-16

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