ES2134762T3 - Formas multimericas de proteinas receptoras de rinovirus humanos. - Google Patents

Formas multimericas de proteinas receptoras de rinovirus humanos.

Info

Publication number
ES2134762T3
ES2134762T3 ES91111272T ES91111272T ES2134762T3 ES 2134762 T3 ES2134762 T3 ES 2134762T3 ES 91111272 T ES91111272 T ES 91111272T ES 91111272 T ES91111272 T ES 91111272T ES 2134762 T3 ES2134762 T3 ES 2134762T3
Authority
ES
Spain
Prior art keywords
human rhinovirus
infectivity
forms
multimerical
hrv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91111272T
Other languages
English (en)
Inventor
Jeffrey M Greve
Alan Mcclelland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Application granted granted Critical
Publication of ES2134762T3 publication Critical patent/ES2134762T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS FORMAS Y CONFIGURACIONES DE MOLECULA DE ADHESION INTERCELULAR (ICAM) INCLUYENDO CONFIGURACIONES MULTIMERICAS QUE SE UNEN EFICAZMENTE AL RINOVIRUS HUMANO Y PUEDEN REDUCIR EFICAZMENTE LA INFECCION DE HRV. CUANDO EN UNA CONFIGURACION MULTIMERICA, PREFERIBLEMENTE COMO LOS DIMEROS, ESTAS PROTEINAS EXHIBEN UNA UNION REALZADA DE HRV Y SON CAPACES DE REDUCIR LA INFECCION DE HRV ASI COMO LA INFECCION DE OTROS VIRUS CONOCIDO DE UNIRSE AL GRUPO "MAYOR" DE RECEPTOR DE RINOVIRUS HUMANO (HRR). LAS PROTEINAS MULTIMERIZADAS PUEDEN UTILIZARSE TAMBIEN PARA BLOQUEAR LA INTERACCION TLCAM CON EL ANTIGENO 1 (LFA-1) DE ACCION ASOCIADA LIMFOCITA.
ES91111272T 1990-07-20 1991-07-06 Formas multimericas de proteinas receptoras de rinovirus humanos. Expired - Lifetime ES2134762T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55623890A 1990-07-20 1990-07-20

Publications (1)

Publication Number Publication Date
ES2134762T3 true ES2134762T3 (es) 1999-10-16

Family

ID=24220489

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91111272T Expired - Lifetime ES2134762T3 (es) 1990-07-20 1991-07-06 Formas multimericas de proteinas receptoras de rinovirus humanos.

Country Status (14)

Country Link
US (1) US6096862A (es)
EP (2) EP0468257B1 (es)
JP (1) JP3091527B2 (es)
KR (1) KR100208847B1 (es)
AT (1) ATE184049T1 (es)
DE (1) DE69131564T2 (es)
DK (1) DK0468257T3 (es)
ES (1) ES2134762T3 (es)
FI (1) FI105687B (es)
GR (1) GR3031768T3 (es)
IE (1) IE912552A1 (es)
IL (1) IL98866A0 (es)
PT (1) PT98394B (es)
ZA (1) ZA915678B (es)

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ES2141076T3 (es) 1988-09-01 2000-03-16 Bayer Ag Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
DE69131564T2 (de) * 1990-07-20 2000-01-13 Bayer Ag Multimere Formen des menschlichen Rhinovirus-Rezeptorproteins
US6130202A (en) * 1990-07-20 2000-10-10 Bayer Corporation Antiviral methods
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5891841A (en) * 1991-06-11 1999-04-06 The Center For Blood Research, Inc. Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof
US6153395A (en) * 1992-01-27 2000-11-28 Icos Corporation ICAM-related protein
US6818743B1 (en) 1992-01-27 2004-11-16 Icos Corporation I-CAM related protein
EP0578819A4 (en) * 1992-01-27 1994-10-12 Icos Corp Icam-related protein.
US5532127A (en) * 1992-01-27 1996-07-02 Icos Corporation Assay for 1-CAM related protein expression
US5989843A (en) * 1992-01-27 1999-11-23 Icos Corporation Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein
US5773293A (en) * 1992-01-27 1998-06-30 Icos Corporation Anti-ICAM-4 antibodies and hybridomas
US5852170A (en) * 1992-01-27 1998-12-22 Icos Corporation ICAM-4 materials and methods
US5753502A (en) * 1993-08-05 1998-05-19 Icos Corporation Neuron-specific ICAM-4 promoter
US6100383A (en) * 1992-01-27 2000-08-08 Icos Corporation Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions
US5702917A (en) * 1992-01-27 1997-12-30 Icos Corporation Polynucleotides encoding human ICAM-4
US5837822A (en) * 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
US5525487A (en) * 1992-01-27 1996-06-11 Icos Corporation DNA encoding I-CAM related protein
US5700658A (en) * 1992-01-27 1997-12-23 Icos Corporation ICAM-4 materials and methods
EP0604624A4 (en) * 1992-06-22 1997-03-12 Miles Inc MULTIMER FORMS OF HUMAN RHINOVIRUS RECEPTOR PROTEIN.
US5879712A (en) 1995-06-07 1999-03-09 Sri International Method for producing drug-loaded microparticles and an ICAM-1 dosage form so produced
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US20020168367A1 (en) 2000-04-28 2002-11-14 Planet Biotechnology Incorporated Novel immunoadhesins for treating and preventing viral and bacterial diseases
US7951378B2 (en) 2000-04-28 2011-05-31 Planet Biotechnology Inc. Immunoadhesin comprising a chimeric ICAM-1 molecule produced in a plant
EP2040716B1 (en) * 2006-04-04 2010-07-28 Marinomed Biotechnologie GmbH Cellulose sulfate for the treatment of rhinovirus infection
US20080131454A1 (en) * 2006-12-05 2008-06-05 Marinomed Biotechnologie Gmbh Methods and Compositions for the Treatment of Rhinovirus Infections with Carrageenan

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Also Published As

Publication number Publication date
FI913470A0 (fi) 1991-07-18
AU652567B2 (en) 1994-09-01
EP0468257A1 (en) 1992-01-29
EP0987329A2 (en) 2000-03-22
ZA915678B (en) 1992-05-27
KR100208847B1 (ko) 1999-07-15
DK0468257T3 (da) 2000-03-27
EP0987329A3 (en) 2004-03-03
ATE184049T1 (de) 1999-09-15
DE69131564T2 (de) 2000-01-13
JP3091527B2 (ja) 2000-09-25
IE912552A1 (en) 1992-01-29
KR930002511A (ko) 1993-02-23
FI913470A (fi) 1992-01-21
FI105687B (fi) 2000-09-29
PT98394A (pt) 1992-06-30
DE69131564D1 (de) 1999-10-07
AU8117691A (en) 1992-01-23
PT98394B (pt) 1999-01-29
IL98866A0 (en) 1992-07-15
GR3031768T3 (en) 2000-02-29
US6096862A (en) 2000-08-01
EP0468257B1 (en) 1999-09-01
JPH04297499A (ja) 1992-10-21

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