AR059902A2 - Complejo de factor viii/vwf o factor viii:c - Google Patents

Complejo de factor viii/vwf o factor viii:c

Info

Publication number
AR059902A2
AR059902A2 ARP070101059A ARP070101059A AR059902A2 AR 059902 A2 AR059902 A2 AR 059902A2 AR P070101059 A ARP070101059 A AR P070101059A AR P070101059 A ARP070101059 A AR P070101059A AR 059902 A2 AR059902 A2 AR 059902A2
Authority
AR
Argentina
Prior art keywords
factor
viii
vwf
factor viii
complex
Prior art date
Application number
ARP070101059A
Other languages
English (en)
Inventor
Arthur Mitterer
Bernhard Fischer
Oyvind L Schonberger
Kathrin Thomas-Urban
Friedrich Dorner
Jonhann Eibl
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3487946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR059902(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immuno Ag filed Critical Immuno Ag
Publication of AR059902A2 publication Critical patent/AR059902A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a un complejo de factor VIII/vWF obtenible mediante cromatografía de intercambio cationico. Reivindicacion 1: Un complejo Factor VIII/factor von Willebrand (Factor VIII/vWF) caracterizado porque contiene multímeros de alto peso molecular que tienen una actividad vWF específica de al menos 66 U/mg de proteína y una actividad específica de Factor VIII de al menos 500 U/mg de proteína.
ARP070101059A 1997-02-27 2007-03-15 Complejo de factor viii/vwf o factor viii:c AR059902A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0033897A AT406373B (de) 1997-02-27 1997-02-27 Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie

Publications (1)

Publication Number Publication Date
AR059902A2 true AR059902A2 (es) 2008-05-07

Family

ID=3487946

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP980100835A AR010121A1 (es) 1997-02-27 1998-02-25 MÉTODO DE RECUPERACIoN DE COMPLEJO DE FACTOR VIII/FACTOR DE VON WILLEWBRAND (COMPLEJO DE FACTOR VIII/VWF) MEDIANTE CROMATOGRAFíA DE INTERCAMBIO CATIoNICO.
ARP070101059A AR059902A2 (es) 1997-02-27 2007-03-15 Complejo de factor viii/vwf o factor viii:c

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP980100835A AR010121A1 (es) 1997-02-27 1998-02-25 MÉTODO DE RECUPERACIoN DE COMPLEJO DE FACTOR VIII/FACTOR DE VON WILLEWBRAND (COMPLEJO DE FACTOR VIII/VWF) MEDIANTE CROMATOGRAFíA DE INTERCAMBIO CATIoNICO.

Country Status (11)

Country Link
US (3) US6831159B1 (es)
EP (1) EP0971958B2 (es)
JP (1) JP4250771B2 (es)
AR (2) AR010121A1 (es)
AT (2) AT406373B (es)
AU (1) AU744919B2 (es)
CA (1) CA2282841C (es)
DE (1) DE59814211D1 (es)
ES (1) ES2306471T5 (es)
NO (2) NO324902B1 (es)
WO (1) WO1998038220A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
EP1593388A1 (en) * 2004-05-05 2005-11-09 ZLB Behring GmbH Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
ES2298096B1 (es) 2008-01-08 2009-01-01 Grifols, S.A. Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos.
HRP20130414T1 (en) 2008-10-21 2013-06-30 Baxter International Inc. Lyophilized recombinant vwf formulations
HUE026907T2 (en) * 2009-08-20 2016-07-28 Baxalta Inc Clean VWF to enhance removal of non-lipid enveloped viruses
RU2579977C2 (ru) 2009-11-13 2016-04-10 Грифольс Терапьютикс Инк. СОДЕРЖАЩИЕ ФАКТОР ФОН ВИЛЛЕБРАНДА (vWF) ПРЕПАРАТЫ И СПОСОБЫ, НАБОРЫ И ПРИМЕНЕНИЯ, СВЯЗАННЫЕ С НИМИ
KR101997543B1 (ko) 2010-07-30 2019-07-09 이엠디 밀리포어 코포레이션 크로마토그래피 매질 및 방법
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
DK3412305T3 (da) * 2011-06-10 2021-03-01 Baxalta GmbH Behandling af koagulationssygdom ved administration af rekombinant vwf
HRP20171272T4 (hr) 2011-08-02 2020-08-07 Baxalta GmbH Sustavi i metode za povećanje prinosa proteina iz postupka rekombinatne proizvodnje
NZ631702A (en) 2012-06-15 2017-01-27 Grains Res & Dev Corp Production of long chain polyunsaturated fatty acids in plant cells
US20150315263A1 (en) * 2012-11-30 2015-11-05 Centre For Bioseparation Technology - Vit Monolith-based pseudo-bioaffinity purification methods for factor viii and applications thereof
DK3066119T3 (en) * 2013-11-08 2018-11-12 Csl Ltd NEW PROCEDURE FOR CONCENTRATION OF THE VON WILLEBRAND FACTOR OR COMPLEXES OF IT
EP3082405A4 (en) 2013-12-18 2017-12-13 Commonwealth Scientific and Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
PH12016502586B1 (en) 2014-06-27 2023-07-19 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid
EP3188816B1 (en) 2014-09-02 2021-06-09 EMD Millipore Corporation Chromatography media comprising discrete porous bundles of nanofibrils
CA2966515C (en) 2014-12-08 2021-04-27 Emd Millipore Corporation Mixed bed ion exchange adsorber
JP7307047B2 (ja) 2017-07-07 2023-07-11 武田薬品工業株式会社 組換えｖｗｆの投与による重度のフォンヴィレブランド病を患う患者における消化管出血の治療
JP2022524291A (ja) 2019-02-01 2022-05-02 武田薬品工業株式会社 組換えＶＷＦ（ｒＶＷＦ）を使用する予防治療法
CN114106145B (zh) * 2021-10-22 2023-09-01 山东泰邦生物制品有限公司 一种血源人凝血因子ⅷ/血管性血友病因子复合物生产工艺

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
US5200510A (en) * 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
FR2651437A1 (fr) 1989-09-05 1991-03-08 Lille Transfusion Sanguine Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total.
NZ237244A (en) * 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IT1256622B (it) † 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
CA2159044A1 (en) * 1994-09-26 1996-03-27 Falko-Guenter Falkner Method of quantitating nucleic acids
DE4435392B4 (de) * 1994-10-04 2008-02-07 Immuno Ag Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF
DE4435485C1 (de) * 1994-10-04 1996-03-21 Immuno Ag Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
CA2251558C (en) 1996-04-12 2005-11-22 Immuno Aktiengesellschaft Highly purified factor viii complex
AT403765B (de) 1996-04-12 1998-05-25 Immuno Ag Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex
AT406373B (de) 1997-02-27 2000-04-25 Immuno Ag Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie
AT405403B (de) 1997-02-27 1999-08-25 Immuno Ag Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie

Also Published As

Publication number Publication date
ES2306471T5 (es) 2012-06-07
ES2306471T3 (es) 2008-11-01
NO994137D0 (no) 1999-08-26
NO20071357L (no) 1999-08-26
US6831159B1 (en) 2004-12-14
AU6080698A (en) 1998-09-18
NO326257B1 (no) 2008-10-27
AU744919B2 (en) 2002-03-07
CA2282841A1 (en) 1998-09-03
EP0971958A1 (de) 2000-01-19
JP4250771B2 (ja) 2009-04-08
US20050239171A1 (en) 2005-10-27
US20020058625A1 (en) 2002-05-16
EP0971958B2 (de) 2012-02-08
DE59814211D1 (de) 2008-05-21
NO994137L (no) 1999-08-26
WO1998038220A1 (de) 1998-09-03
US7648958B2 (en) 2010-01-19
ATE391728T1 (de) 2008-04-15
CA2282841C (en) 2008-12-02
EP0971958B1 (de) 2008-04-09
US6953837B2 (en) 2005-10-11
AR010121A1 (es) 2000-05-17
AT406373B (de) 2000-04-25
ATA33897A (de) 1999-09-15
NO324902B1 (no) 2007-12-27
JP2001517212A (ja) 2001-10-02

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