AR010121A1 - MÉTODO DE RECUPERACIoN DE COMPLEJO DE FACTOR VIII/FACTOR DE VON WILLEWBRAND (COMPLEJO DE FACTOR VIII/VWF) MEDIANTE CROMATOGRAFíA DE INTERCAMBIO CATIoNICO. - Google Patents
MÉTODO DE RECUPERACIoN DE COMPLEJO DE FACTOR VIII/FACTOR DE VON WILLEWBRAND (COMPLEJO DE FACTOR VIII/VWF) MEDIANTE CROMATOGRAFíA DE INTERCAMBIO CATIoNICO.Info
- Publication number
- AR010121A1 AR010121A1 ARP980100835A ARP980100835A AR010121A1 AR 010121 A1 AR010121 A1 AR 010121A1 AR P980100835 A ARP980100835 A AR P980100835A AR P980100835 A ARP980100835 A AR P980100835A AR 010121 A1 AR010121 A1 AR 010121A1
- Authority
- AR
- Argentina
- Prior art keywords
- applicant
- presented
- data
- factor viii
- complex
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe un procedimiento para recuperar un complejo de factor VIII/vWF caracteriza porque el complejo de factor VIII/vWF de una solucion de proteína esintercambiador cationico y es recuperado por elucion escalonada del complejo de VIII/vWF, quec ontiene particularmente multímeros de vWF de alto peso molecular.invencion también se refiere a un complejo de factor VIII/vWF obtenible medianteDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTE DATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANT E DATOS DEL DISQUETTEPRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTE DATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SO LICITANTE DATOS DEL DISQUETTE PRESENTADO POR ELSOLICITANTEDATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTE DATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRESENTADO P OR EL SOLICITANTE DATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DELDISQUETTE PRESENTADO POR EL SOLICITANTE DATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTEDATOS DEL DISQUETTE PRES ENTADO POR EL SOLICITANTE DATOS DEL DISQUETTE PRESENTADO POR EL SOLICITANTE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0033897A AT406373B (de) | 1997-02-27 | 1997-02-27 | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR010121A1 true AR010121A1 (es) | 2000-05-17 |
Family
ID=3487946
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100835A AR010121A1 (es) | 1997-02-27 | 1998-02-25 | MÉTODO DE RECUPERACIoN DE COMPLEJO DE FACTOR VIII/FACTOR DE VON WILLEWBRAND (COMPLEJO DE FACTOR VIII/VWF) MEDIANTE CROMATOGRAFíA DE INTERCAMBIO CATIoNICO. |
| ARP070101059A AR059902A2 (es) | 1997-02-27 | 2007-03-15 | Complejo de factor viii/vwf o factor viii:c |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101059A AR059902A2 (es) | 1997-02-27 | 2007-03-15 | Complejo de factor viii/vwf o factor viii:c |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6831159B1 (es) |
| EP (1) | EP0971958B2 (es) |
| JP (1) | JP4250771B2 (es) |
| AR (2) | AR010121A1 (es) |
| AT (2) | AT406373B (es) |
| AU (1) | AU744919B2 (es) |
| CA (1) | CA2282841C (es) |
| DE (1) | DE59814211D1 (es) |
| ES (1) | ES2306471T5 (es) |
| NO (2) | NO324902B1 (es) |
| WO (1) | WO1998038220A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
| EP1593388A1 (en) * | 2004-05-05 | 2005-11-09 | ZLB Behring GmbH | Therapeutic plasma protein-concentrates containing von willebrand factor as high molecular weight multimers |
| US11197916B2 (en) | 2007-12-28 | 2021-12-14 | Takeda Pharmaceutical Company Limited | Lyophilized recombinant VWF formulations |
| ES2298096B1 (es) | 2008-01-08 | 2009-01-01 | Grifols, S.A. | Procedimiento para la obtencion de un concentrado de factor von willebrand o del complejo de factor viii/factor von willebrand y utilizacionde los mismos. |
| TWI508735B (zh) | 2008-10-21 | 2015-11-21 | 巴克斯特國際公司 | 凍乾的重組ｖｗｆ調配物 |
| JP5838159B2 (ja) * | 2009-08-20 | 2015-12-24 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | 非脂質エンベロープウイルスの除去を高めるためのｖｗｆの精製 |
| EP2499165B1 (en) | 2009-11-13 | 2016-09-14 | Grifols Therapeutics Inc. | Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto |
| KR20130031351A (ko) | 2010-07-30 | 2013-03-28 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 및 방법 |
| US9488625B2 (en) | 2010-12-15 | 2016-11-08 | Baxalta GmbH | Purification of factor VIII using a conductivity gradient |
| HUE039317T2 (hu) * | 2011-06-10 | 2018-12-28 | Baxalta GmbH | Koagulációs betegség kezelése rekombináns VWF adagolásával |
| US9534037B2 (en) | 2011-08-02 | 2017-01-03 | Baxalta GmbH | Systems and methods to increase protein yield from recombinant manufacturing processes |
| NZ631702A (en) | 2012-06-15 | 2017-01-27 | Grains Res & Dev Corp | Production of long chain polyunsaturated fatty acids in plant cells |
| WO2014083510A1 (en) * | 2012-11-30 | 2014-06-05 | Centre For Bioseparation Technology - Vit | Monolith-based pseudo-bioaffinity purification methods for factor viii and applications thereof |
| WO2015066769A1 (en) * | 2013-11-08 | 2015-05-14 | Csl Ltd. | New method to concentrate von willebrand factor or complexes thereof |
| CA3241340A1 (en) | 2013-12-18 | 2015-06-25 | Grains Research And Development Corporation | Lipid comprising long chain polyunsaturated fatty acids |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| KR102072529B1 (ko) | 2014-09-02 | 2020-02-25 | 이엠디 밀리포어 코포레이션 | 나노-피브릴화된 표면 특징을 갖는 고표면적 섬유 매질 |
| KR102162753B1 (ko) | 2014-12-08 | 2020-10-07 | 이엠디 밀리포어 코포레이션 | 혼합층 이온 교환 흡착제 |
| DK3648788T3 (da) | 2017-07-07 | 2024-08-19 | Takeda Pharmaceuticals Co | Behandling af gastrointestinal blødning hos patienter med svær von willebrand-sygdom ved administration af rekombinant vwf |
| CN114106145B (zh) * | 2021-10-22 | 2023-09-01 | 山东泰邦生物制品有限公司 | 一种血源人凝血因子ⅷ/血管性血友病因子复合物生产工艺 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4540573A (en) | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| GB8403473D0 (en) * | 1984-02-09 | 1984-03-14 | Special Trustees For St Thomas | Purification of factor viii |
| US5200510A (en) * | 1987-06-16 | 1993-04-06 | Zymogenetics, Inc. | Method for purifying factor viii:c, von willebrand factor and complexes thereof |
| FR2651437A1 (fr) | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
| NZ237244A (en) * | 1990-03-02 | 1992-10-28 | Bio Technology General Corp | Cloning and production of human von willebrand factor analogues and compositions thereof |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| IT1256622B (it) * | 1992-12-04 | 1995-12-12 | Sclavo Spa | Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale. |
| AT401270B (de) * | 1994-09-26 | 1996-07-25 | Immuno Ag | Verfahren zur quantifizierung von genomischer dna |
| CA2159044A1 (en) | 1994-09-26 | 1996-03-27 | Falko-Guenter Falkner | Method of quantitating nucleic acids |
| DE4435485C1 (de) | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
| DE4435392B4 (de) | 1994-10-04 | 2008-02-07 | Immuno Ag | Verfahren zur Trennung von vWF in hochmolekularen vWF und niedermolekularen vWF |
| AT403764B (de) | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| CA2251558C (en) | 1996-04-12 | 2005-11-22 | Immuno Aktiengesellschaft | Highly purified factor viii complex |
| AT403765B (de) | 1996-04-12 | 1998-05-25 | Immuno Ag | Verfahren zur herstellung einer präparation enthaltend einen hochgereinigten komplex |
| AT406373B (de) | 1997-02-27 | 2000-04-25 | Immuno Ag | Verfahren zur reinigung von faktor viii/vwf-komplex mittels kationenaustauscherchromatographie |
| AT405403B (de) | 1997-02-27 | 1999-08-25 | Immuno Ag | Reinigung von von willebrand-faktor durch kationenaustauscherchromatographie |
-
1997
- 1997-02-27 AT AT0033897A patent/AT406373B/de not_active IP Right Cessation
-
1998
- 1998-02-25 AR ARP980100835A patent/AR010121A1/es active IP Right Grant
- 1998-02-27 CA CA002282841A patent/CA2282841C/en not_active Expired - Lifetime
- 1998-02-27 AU AU60806/98A patent/AU744919B2/en not_active Expired
- 1998-02-27 DE DE59814211T patent/DE59814211D1/de not_active Expired - Lifetime
- 1998-02-27 EP EP98905132A patent/EP0971958B2/de not_active Expired - Lifetime
- 1998-02-27 JP JP53706098A patent/JP4250771B2/ja not_active Expired - Lifetime
- 1998-02-27 WO PCT/AT1998/000043 patent/WO1998038220A1/de active IP Right Grant
- 1998-02-27 AT AT98905132T patent/ATE391728T1/de active
- 1998-02-27 US US09/367,459 patent/US6831159B1/en not_active Expired - Lifetime
- 1998-02-27 ES ES98905132T patent/ES2306471T5/es not_active Expired - Lifetime
-
1999
- 1999-08-26 NO NO19994137A patent/NO324902B1/no not_active IP Right Cessation
-
2001
- 2001-11-02 US US10/003,621 patent/US6953837B2/en not_active Expired - Lifetime
-
2004
- 2004-02-27 US US10/789,562 patent/US7648958B2/en not_active Expired - Fee Related
-
2007
- 2007-03-13 NO NO20071357A patent/NO326257B1/no not_active IP Right Cessation
- 2007-03-15 AR ARP070101059A patent/AR059902A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001517212A (ja) | 2001-10-02 |
| WO1998038220A1 (de) | 1998-09-03 |
| AU744919B2 (en) | 2002-03-07 |
| ES2306471T5 (es) | 2012-06-07 |
| EP0971958A1 (de) | 2000-01-19 |
| US6953837B2 (en) | 2005-10-11 |
| NO324902B1 (no) | 2007-12-27 |
| AU6080698A (en) | 1998-09-18 |
| US6831159B1 (en) | 2004-12-14 |
| CA2282841A1 (en) | 1998-09-03 |
| JP4250771B2 (ja) | 2009-04-08 |
| ATA33897A (de) | 1999-09-15 |
| EP0971958B2 (de) | 2012-02-08 |
| NO994137L (no) | 1999-08-26 |
| NO20071357L (no) | 1999-08-26 |
| EP0971958B1 (de) | 2008-04-09 |
| NO994137D0 (no) | 1999-08-26 |
| ATE391728T1 (de) | 2008-04-15 |
| DE59814211D1 (de) | 2008-05-21 |
| CA2282841C (en) | 2008-12-02 |
| ES2306471T3 (es) | 2008-11-01 |
| US20050239171A1 (en) | 2005-10-27 |
| NO326257B1 (no) | 2008-10-27 |
| AR059902A2 (es) | 2008-05-07 |
| AT406373B (de) | 2000-04-25 |
| US7648958B2 (en) | 2010-01-19 |
| US20020058625A1 (en) | 2002-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |