ES2183843T3 - Compuestos triciclicos que tienen afinidad por el receptor 5-ht1a. - Google Patents

Compuestos triciclicos que tienen afinidad por el receptor 5-ht1a.

Info

Publication number
ES2183843T3
ES2183843T3 ES94930720T ES94930720T ES2183843T3 ES 2183843 T3 ES2183843 T3 ES 2183843T3 ES 94930720 T ES94930720 T ES 94930720T ES 94930720 T ES94930720 T ES 94930720T ES 2183843 T3 ES2183843 T3 ES 2183843T3
Authority
ES
Spain
Prior art keywords
ht1a
affinity
receiver
compounds
tricycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94930720T
Other languages
English (en)
Inventor
Ellen W Baxter
Allen B Reitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Application granted granted Critical
Publication of ES2183843T3 publication Critical patent/ES2183843T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPUESTOS REPRESENTADOS POR LA FORMULA GENERAL (I) QUE TIENEN AFINIDAD PARA EL RECEPTOR 5-HT1A SE REVELAN COMO UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL.
ES94930720T 1993-10-25 1994-10-11 Compuestos triciclicos que tienen afinidad por el receptor 5-ht1a. Expired - Lifetime ES2183843T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/142,748 US5512566A (en) 1993-10-25 1993-10-25 Tricyclic compounds having affinity for the 5-HT1A receptor

Publications (1)

Publication Number Publication Date
ES2183843T3 true ES2183843T3 (es) 2003-04-01

Family

ID=22501119

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94930720T Expired - Lifetime ES2183843T3 (es) 1993-10-25 1994-10-11 Compuestos triciclicos que tienen afinidad por el receptor 5-ht1a.

Country Status (15)

Country Link
US (1) US5512566A (es)
EP (1) EP0746556B1 (es)
JP (1) JP3709203B2 (es)
AT (1) ATE224895T1 (es)
AU (1) AU680562B2 (es)
CA (1) CA2174850A1 (es)
DE (1) DE69431441T2 (es)
DK (1) DK0746556T3 (es)
ES (1) ES2183843T3 (es)
IL (1) IL111246A (es)
NZ (1) NZ275689A (es)
PT (1) PT746556E (es)
SI (1) SI0746556T1 (es)
WO (1) WO1995011903A1 (es)
ZA (1) ZA948354B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688950A (en) * 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755584A (en) * 1972-04-03 1973-08-28 Abbott Lab Tranquilizers
IT1052009B (it) * 1975-12-30 1981-06-20 Erba Carlo Spa Imidazo 4.3 c 1.4 benzossazino imidazo 4.3 c 1.4 benzotiazino pirazo 2.1 c 1.4 benzossazino e pirazo 2.1 c 1.4 benzotiazino derivati
ES2090119T3 (es) * 1988-12-15 1996-10-16 Abbott Lab Agentes selectivos de 5-ht.
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
US5244888A (en) * 1989-11-17 1993-09-14 Abbott Laboratories 5-HT selective agents
DE69131123T2 (de) * 1990-01-11 1999-09-30 Upjohn Co 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem
WO1991013872A1 (en) * 1990-03-15 1991-09-19 The Upjohn Company Therapeutically useful heterocyclic indole compounds
JPH07500333A (ja) * 1991-10-24 1995-01-12 ジ・アップジョン・カンパニー ベンゾ−イソキノリン誘導体
EP0539209A1 (en) * 1991-10-24 1993-04-28 The Upjohn Company Benzo-isoquinoline derivatives and analogs and their use in therapeutics

Also Published As

Publication number Publication date
DK0746556T3 (da) 2002-12-16
NZ275689A (en) 1997-12-19
CA2174850A1 (en) 1995-05-04
WO1995011903A1 (en) 1995-05-04
EP0746556A1 (en) 1996-12-11
JPH09504789A (ja) 1997-05-13
IL111246A (en) 1998-01-04
AU7975794A (en) 1995-05-22
DE69431441T2 (de) 2003-10-23
IL111246A0 (en) 1994-12-29
AU680562B2 (en) 1997-07-31
ATE224895T1 (de) 2002-10-15
US5512566A (en) 1996-04-30
PT746556E (pt) 2002-12-31
DE69431441D1 (de) 2002-10-31
JP3709203B2 (ja) 2005-10-26
ZA948354B (en) 1996-04-24
SI0746556T1 (en) 2003-02-28
EP0746556B1 (en) 2002-09-25

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ES2183843T3 (es) Compuestos triciclicos que tienen afinidad por el receptor 5-ht1a.