JPH09504789A - 5−ht1aレセプターに対して親和性をもつ三環式化合物 - Google Patents
5−ht1aレセプターに対して親和性をもつ三環式化合物Info
- Publication number
- JPH09504789A JPH09504789A JP7512659A JP51265995A JPH09504789A JP H09504789 A JPH09504789 A JP H09504789A JP 7512659 A JP7512659 A JP 7512659A JP 51265995 A JP51265995 A JP 51265995A JP H09504789 A JPH09504789 A JP H09504789A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- benzoyl
- methyl
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 一般式Iによって表される化合物またはそれらのラセミ化合物、個々の 異性体、水和物、ソルベートもしくは酸付加塩: 式中、R1およびR2は、独立して、H、ハロゲン、C1−C6アルコキシ、C1− C6アルキルもしくはトリフルオロメチルのいずれかから選ばれ; Xは、nが1である場合にはOであり、そしてXは、nが0である場合にはN Hであり; 式中、Yは、CH2であり; 式中、nは、0もしくは1であり; 式中、Zは、XがOである場合にはNであり、そしてZは、XがNHである場 合にはCであり; 式中、R3およびR4は、もし、R3およびR4が、同時に両方ともC1−C8アシ ルではない場合には、独立して、H、C1−C6アルキル、C1−C8アシルのいず れかから選ばれるか、あるいは、一緒になって、Nとともに、単環式5−7員飽 和環、または芳香環アリルに縮合された5員環を形成するように使われてもよい 。 2. R1およびR2が、各々Hである、請求の範囲1の化合物。 3. XがOであり、そしてnが1である、請求の範囲1の化合物。 4. Xが、NHであり、そしてnが0である、請求の範囲1の化合物。 5. R3およびR4が、Nと一緒になって、6員飽和環を形成するか、または Nと一緒になって、式: の二環式環構造を形成する、請求の範囲1の化合物。 6. R3およびR4が、一緒になって、Nとともに、6員飽和環を形成する、 請求の範囲1の化合物。 7. 化合物が、 1−(3−(2−(1,2,3,4−テトラヒドロ−9H−ピリド(3,4− b)インドリル)メチル)ベンゾイル)ピペリジン; 1−(3−(2−(1,2,3,4−テトラヒドロ−9H−ピリド(3,4− b)インドリル)メチル)ベンゾイル)インドリン; 1−(3−(1−(1,2,3,4,4a,5−ヘキサヒドロピラジノ(1, 2−c)−1,4−ベンズオキサジニル)メチル)ベンゾイル)ピペリジン;ま たは 1−(3−(3−(1,2,3,4,4a,5−ヘキサヒドロピラジノ(1, 2−c)−1,4−ベンズオキサジニル)メチル)ベンゾイル)インドリン のいずれかから選ばれる、請求の範囲1の化合物。 8. 適切な薬物キャリアーとの組み合わせにおいて、請求の範囲1の化合物 を含む医薬組成物であって、前記化合物が、中枢神経系の病気を治療するための 治療学的有効量で存在する組成物。 9. 中枢神経系の病気を治療する方法であって、そのような病気を治療する のに十分な量の請求の範囲1の化合物を、そのような病気に罹った動物に投与す ることを含む方法。 10.病気が不安である、請求の範囲9の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US142,748 | 1993-10-25 | ||
US08/142,748 US5512566A (en) | 1993-10-25 | 1993-10-25 | Tricyclic compounds having affinity for the 5-HT1A receptor |
PCT/US1994/011544 WO1995011903A1 (en) | 1993-10-25 | 1994-10-11 | Tricyclic compounds having affinity for the 5-ht1a receptor |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09504789A true JPH09504789A (ja) | 1997-05-13 |
JP3709203B2 JP3709203B2 (ja) | 2005-10-26 |
Family
ID=22501119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51265995A Expired - Fee Related JP3709203B2 (ja) | 1993-10-25 | 1994-10-11 | 5−ht1aレセプターに対して親和性をもつ三環式化合物 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5512566A (ja) |
EP (1) | EP0746556B1 (ja) |
JP (1) | JP3709203B2 (ja) |
AT (1) | ATE224895T1 (ja) |
AU (1) | AU680562B2 (ja) |
CA (1) | CA2174850A1 (ja) |
DE (1) | DE69431441T2 (ja) |
DK (1) | DK0746556T3 (ja) |
ES (1) | ES2183843T3 (ja) |
IL (1) | IL111246A (ja) |
NZ (1) | NZ275689A (ja) |
PT (1) | PT746556E (ja) |
SI (1) | SI0746556T1 (ja) |
WO (1) | WO1995011903A1 (ja) |
ZA (1) | ZA948354B (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5688950A (en) * | 1996-04-23 | 1997-11-18 | Neurogen Corporation | Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3755584A (en) * | 1972-04-03 | 1973-08-28 | Abbott Lab | Tranquilizers |
IT1052009B (it) * | 1975-12-30 | 1981-06-20 | Erba Carlo Spa | Imidazo 4.3 c 1.4 benzossazino imidazo 4.3 c 1.4 benzotiazino pirazo 2.1 c 1.4 benzossazino e pirazo 2.1 c 1.4 benzotiazino derivati |
AU626621B2 (en) * | 1988-12-15 | 1992-08-06 | Abbott Laboratories | Substituted hexahydro-indenopyrroles, -indenopyridines, and -benzoisoindoles as 5-ht selective agents |
US5049564A (en) * | 1989-11-17 | 1991-09-17 | Abbott Laboratories | 5-HT selective agents |
US5244888A (en) * | 1989-11-17 | 1993-09-14 | Abbott Laboratories | 5-HT selective agents |
DK0510068T3 (da) * | 1990-01-11 | 1999-10-25 | Upjohn Co | Nye 6,7,8,9-tetrahydro-3H-benz(e)indol-heterocycler med virkning på centralnervesystemet |
JPH05505599A (ja) * | 1990-03-15 | 1993-08-19 | ジ・アップジョン・カンパニー | 治療上有用な複素環インドール化合物類 |
EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
CA2118920A1 (en) * | 1991-10-24 | 1993-04-29 | Arthur G. Romero | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
-
1993
- 1993-10-25 US US08/142,748 patent/US5512566A/en not_active Expired - Lifetime
-
1994
- 1994-10-11 DK DK94930720T patent/DK0746556T3/da active
- 1994-10-11 DE DE69431441T patent/DE69431441T2/de not_active Expired - Fee Related
- 1994-10-11 AU AU79757/94A patent/AU680562B2/en not_active Ceased
- 1994-10-11 EP EP94930720A patent/EP0746556B1/en not_active Expired - Lifetime
- 1994-10-11 ES ES94930720T patent/ES2183843T3/es not_active Expired - Lifetime
- 1994-10-11 JP JP51265995A patent/JP3709203B2/ja not_active Expired - Fee Related
- 1994-10-11 IL IL111246A patent/IL111246A/en not_active IP Right Cessation
- 1994-10-11 CA CA002174850A patent/CA2174850A1/en not_active Abandoned
- 1994-10-11 AT AT94930720T patent/ATE224895T1/de active
- 1994-10-11 WO PCT/US1994/011544 patent/WO1995011903A1/en active IP Right Grant
- 1994-10-11 NZ NZ275689A patent/NZ275689A/en unknown
- 1994-10-11 PT PT94930720T patent/PT746556E/pt unknown
- 1994-10-11 SI SI9430418T patent/SI0746556T1/xx unknown
- 1994-10-24 ZA ZA948354A patent/ZA948354B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES2183843T3 (es) | 2003-04-01 |
JP3709203B2 (ja) | 2005-10-26 |
ATE224895T1 (de) | 2002-10-15 |
EP0746556A1 (en) | 1996-12-11 |
DE69431441D1 (de) | 2002-10-31 |
AU7975794A (en) | 1995-05-22 |
ZA948354B (en) | 1996-04-24 |
WO1995011903A1 (en) | 1995-05-04 |
AU680562B2 (en) | 1997-07-31 |
US5512566A (en) | 1996-04-30 |
DK0746556T3 (da) | 2002-12-16 |
CA2174850A1 (en) | 1995-05-04 |
NZ275689A (en) | 1997-12-19 |
DE69431441T2 (de) | 2003-10-23 |
IL111246A0 (en) | 1994-12-29 |
SI0746556T1 (en) | 2003-02-28 |
PT746556E (pt) | 2002-12-31 |
EP0746556B1 (en) | 2002-09-25 |
IL111246A (en) | 1998-01-04 |
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