DE69431441D1 - Trizyklische verbindungen mit affinität für den 5-ht1a rezeptor - Google Patents

Trizyklische verbindungen mit affinität für den 5-ht1a rezeptor

Info

Publication number
DE69431441D1
DE69431441D1 DE69431441T DE69431441T DE69431441D1 DE 69431441 D1 DE69431441 D1 DE 69431441D1 DE 69431441 T DE69431441 T DE 69431441T DE 69431441 T DE69431441 T DE 69431441T DE 69431441 D1 DE69431441 D1 DE 69431441D1
Authority
DE
Germany
Prior art keywords
tricyclic
affinity
connections
ht1a receptor
ht1a
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431441T
Other languages
English (en)
Other versions
DE69431441T2 (de
Inventor
W Baxter
B Reitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of DE69431441D1 publication Critical patent/DE69431441D1/de
Publication of DE69431441T2 publication Critical patent/DE69431441T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69431441T 1993-10-25 1994-10-11 Trizyklische verbindungen mit affinität für den 5-ht1a rezeptor Expired - Fee Related DE69431441T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/142,748 US5512566A (en) 1993-10-25 1993-10-25 Tricyclic compounds having affinity for the 5-HT1A receptor
PCT/US1994/011544 WO1995011903A1 (en) 1993-10-25 1994-10-11 Tricyclic compounds having affinity for the 5-ht1a receptor

Publications (2)

Publication Number Publication Date
DE69431441D1 true DE69431441D1 (de) 2002-10-31
DE69431441T2 DE69431441T2 (de) 2003-10-23

Family

ID=22501119

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431441T Expired - Fee Related DE69431441T2 (de) 1993-10-25 1994-10-11 Trizyklische verbindungen mit affinität für den 5-ht1a rezeptor

Country Status (15)

Country Link
US (1) US5512566A (de)
EP (1) EP0746556B1 (de)
JP (1) JP3709203B2 (de)
AT (1) ATE224895T1 (de)
AU (1) AU680562B2 (de)
CA (1) CA2174850A1 (de)
DE (1) DE69431441T2 (de)
DK (1) DK0746556T3 (de)
ES (1) ES2183843T3 (de)
IL (1) IL111246A (de)
NZ (1) NZ275689A (de)
PT (1) PT746556E (de)
SI (1) SI0746556T1 (de)
WO (1) WO1995011903A1 (de)
ZA (1) ZA948354B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688950A (en) * 1996-04-23 1997-11-18 Neurogen Corporation Tricyclic aminoalkylcarboxamides; novel dopamine D3 receptor subtype specific ligands

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755584A (en) * 1972-04-03 1973-08-28 Abbott Lab Tranquilizers
IT1052009B (it) * 1975-12-30 1981-06-20 Erba Carlo Spa Imidazo 4.3 c 1.4 benzossazino imidazo 4.3 c 1.4 benzotiazino pirazo 2.1 c 1.4 benzossazino e pirazo 2.1 c 1.4 benzotiazino derivati
ATE139230T1 (de) * 1988-12-15 1996-06-15 Abbott Lab 5-ht-selektive mittel
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
US5244888A (en) * 1989-11-17 1993-09-14 Abbott Laboratories 5-HT selective agents
JP3049089B2 (ja) * 1990-01-11 2000-06-05 ファルマシア・アンド・アップジョン・カンパニー 新規な中枢作用性の６，７，８，９―テトラヒドロ―３Ｈ―ベンズ［ｅ］インドールヘテロ環式化合物
CA2075057A1 (en) * 1990-03-15 1991-09-16 Pharmacia & Upjohn Company Llc Therapeutically useful heterocyclic indole compounds
AU2559392A (en) * 1991-10-24 1993-05-21 Upjohn Company, The Benzo-isoquinoline derivatives and analogs and their use in therapeutics
EP0539209A1 (de) * 1991-10-24 1993-04-28 The Upjohn Company Benzo-Isochinoline Derivate und Analoge und ihre Anwendung in der Therapie

Also Published As

Publication number Publication date
DE69431441T2 (de) 2003-10-23
ES2183843T3 (es) 2003-04-01
IL111246A (en) 1998-01-04
SI0746556T1 (en) 2003-02-28
ZA948354B (en) 1996-04-24
WO1995011903A1 (en) 1995-05-04
ATE224895T1 (de) 2002-10-15
CA2174850A1 (en) 1995-05-04
AU680562B2 (en) 1997-07-31
EP0746556B1 (de) 2002-09-25
IL111246A0 (en) 1994-12-29
JP3709203B2 (ja) 2005-10-26
DK0746556T3 (da) 2002-12-16
PT746556E (pt) 2002-12-31
JPH09504789A (ja) 1997-05-13
AU7975794A (en) 1995-05-22
US5512566A (en) 1996-04-30
NZ275689A (en) 1997-12-19
EP0746556A1 (de) 1996-12-11

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ORTHO-MCNEIL PHARMACEUTICAL, INC., NEW BRUNSWICK,

8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN

8339 Ceased/non-payment of the annual fee