ES2127946T3 - Antagonistas de neurocinina diazabiciclica. - Google Patents

Antagonistas de neurocinina diazabiciclica.

Info

Publication number
ES2127946T3
ES2127946T3 ES94931148T ES94931148T ES2127946T3 ES 2127946 T3 ES2127946 T3 ES 2127946T3 ES 94931148 T ES94931148 T ES 94931148T ES 94931148 T ES94931148 T ES 94931148T ES 2127946 T3 ES2127946 T3 ES 2127946T3
Authority
ES
Spain
Prior art keywords
neurocinine
diazabyclic
antagonists
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94931148T
Other languages
English (en)
Inventor
Harry R Howard Jr
Kevin D Shenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2127946T3 publication Critical patent/ES2127946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DIAZABICICLICOS Y, ESPECIFICAMENTE A COMPUESTOS DE LA FORMULA (I), EN LA QUE A, G, R1, R2, R3, R4, R5, R6 Y R7 SON SEGUN SE DEFINEN EN LA ESPECIFICACION. LOS COMPUESTOS DE LA FORMULA (I) SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS Y DEL SISTEMA NERVIOSO CENTRAL, ASI COMO DE OTRAS ENFERMEDADES.
ES94931148T 1993-12-29 1994-11-14 Antagonistas de neurocinina diazabiciclica. Expired - Lifetime ES2127946T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17503493A 1993-12-29 1993-12-29

Publications (1)

Publication Number Publication Date
ES2127946T3 true ES2127946T3 (es) 1999-05-01

Family

ID=22638565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94931148T Expired - Lifetime ES2127946T3 (es) 1993-12-29 1994-11-14 Antagonistas de neurocinina diazabiciclica.

Country Status (26)

Country Link
US (2) US5854239A (es)
EP (1) EP0737194B1 (es)
JP (1) JP2895630B2 (es)
KR (1) KR100197454B1 (es)
CN (1) CN1046515C (es)
AT (1) ATE177099T1 (es)
AU (1) AU699465B2 (es)
BR (1) BR9408450A (es)
CA (1) CA2180263C (es)
CO (1) CO4230019A1 (es)
CZ (1) CZ282567B6 (es)
DE (1) DE69416869T2 (es)
DK (1) DK0737194T3 (es)
ES (1) ES2127946T3 (es)
FI (1) FI108296B (es)
GR (1) GR3029853T3 (es)
HU (1) HUT74682A (es)
IL (1) IL112118A (es)
NO (1) NO305600B1 (es)
NZ (1) NZ274915A (es)
PE (1) PE49395A1 (es)
PL (1) PL179435B1 (es)
RU (1) RU2124014C1 (es)
TW (1) TW369526B (es)
WO (1) WO1995018129A1 (es)
ZA (1) ZA9410339B (es)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
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ATE177099T1 (de) * 1993-12-29 1999-03-15 Pfizer Diazabicyclische neurokinin antagonisten
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WO2001095904A1 (en) * 2000-06-12 2001-12-20 University Of Rochester Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
CA2415532C (en) 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
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RU2368614C2 (ru) * 2004-02-04 2009-09-27 НьюроСёрч А/С Диазабициклические арильные производные в качестве модуляторов холинергических рецепторов
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Also Published As

Publication number Publication date
EP0737194B1 (en) 1999-03-03
HU9601790D0 (en) 1996-09-30
ZA9410339B (en) 1996-06-28
NZ274915A (en) 1997-11-24
US6110919A (en) 2000-08-29
ATE177099T1 (de) 1999-03-15
WO1995018129A1 (en) 1995-07-06
DE69416869D1 (de) 1999-04-08
NO962742D0 (no) 1996-06-28
JPH09500904A (ja) 1997-01-28
GR3029853T3 (en) 1999-07-30
NO305600B1 (no) 1999-06-28
TW369526B (en) 1999-09-11
CN1046515C (zh) 1999-11-17
IL112118A (en) 1998-10-30
PL315193A1 (en) 1996-10-14
FI108296B (fi) 2001-12-31
PL179435B1 (pl) 2000-09-29
US5854239A (en) 1998-12-29
CN1139434A (zh) 1997-01-01
CA2180263C (en) 2000-05-16
FI946140L (fi) 1995-06-30
NO962742L (no) 1996-06-28
EP0737194A1 (en) 1996-10-16
RU2124014C1 (ru) 1998-12-27
IL112118A0 (en) 1995-03-15
DK0737194T3 (da) 1999-09-27
HUT74682A (en) 1997-01-28
PE49395A1 (es) 1996-01-06
CO4230019A1 (es) 1995-10-19
BR9408450A (pt) 1997-08-05
FI946140A0 (fi) 1994-12-28
KR100197454B1 (ko) 1999-06-15
CZ188696A3 (en) 1996-10-16
AU699465B2 (en) 1998-12-03
CZ282567B6 (cs) 1997-08-13
DE69416869T2 (de) 1999-07-01
JP2895630B2 (ja) 1999-05-24
AU8002194A (en) 1995-07-17

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