MX9700305A - Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1. - Google Patents

Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1.

Info

Publication number
MX9700305A
MX9700305A MX9700305A MX9700305A MX9700305A MX 9700305 A MX9700305 A MX 9700305A MX 9700305 A MX9700305 A MX 9700305A MX 9700305 A MX9700305 A MX 9700305A MX 9700305 A MX9700305 A MX 9700305A
Authority
MX
Mexico
Prior art keywords
novel
new class
specific ligands
deazapurine derivatives
crf1
Prior art date
Application number
MX9700305A
Other languages
English (en)
Inventor
Yuanjun
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Priority claimed from PCT/US1996/006708 external-priority patent/WO1996035689A1/en
Publication of MX9700305A publication Critical patent/MX9700305A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen compuestos de formula (I), en donde Ar representa un grupo arilo o heteroarilo y R1, R2, R3, R4 y R5 representan sustituyentes orgánicos o inorgánicos, los cuales compuestos son agonistas o antagonistas parciales altamente selectivos en los receptores del CRF1 humano y así son utiles en el diagnostico y tratamiento de enfermedades relacionadas con la tension (stress) tales como enfermedad de la tension post-traumática (PTSD) también como depresion, dolor de cabeza y ansiedad.
MX9700305A 1995-06-07 1996-05-09 Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1. MX9700305A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/476,689 US5804685A (en) 1995-06-07 1995-06-07 Deazapurine derivatives: a new class of CRF1 specific ligands
PCT/US1996/006708 WO1996035689A1 (en) 1995-05-12 1996-05-09 Novel deazapurine derivatives; a new class of crf1 specific ligands

Publications (1)

Publication Number Publication Date
MX9700305A true MX9700305A (es) 1998-01-31

Family

ID=23892859

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700305A MX9700305A (es) 1995-06-07 1996-05-09 Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1.

Country Status (2)

Country Link
US (1) US5804685A (es)
MX (1) MX9700305A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716993B2 (en) * 1995-05-12 2000-03-16 Neurogen Corporation Novel deazapurine derivatives; a new class of CRF1 specific ligands
AU738304B2 (en) * 1995-10-13 2001-09-13 Neurogen Corporation Certain pyrrolopyridine derivatives; novel CRF 1 specific ligands
CA2272705C (en) * 1996-11-27 2003-03-18 Pfizer Inc. Fused bicyclic pyrimidine derivatives
US6472402B1 (en) 1998-04-02 2002-10-29 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
WO1999051597A1 (en) 1998-04-02 1999-10-14 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole and 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole derivatives: crf1 specific ligands
ES2196820T3 (es) 1998-06-09 2003-12-16 Neurogen Corp Derivados de pirido(2,3-b)indolizina y aza-analogos de la misma; ligandos especificos de crf 1.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5063245A (en) * 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
US6765008B1 (en) * 1992-12-17 2004-07-20 Pfizer Inc Pyrrolopyrimidines as CRF antagonists

Also Published As

Publication number Publication date
US5804685A (en) 1998-09-08

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees