AR007828A1 - Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos - Google Patents

Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos

Info

Publication number
AR007828A1
AR007828A1 ARP970103050A ARP970103050A AR007828A1 AR 007828 A1 AR007828 A1 AR 007828A1 AR P970103050 A ARP970103050 A AR P970103050A AR P970103050 A ARP970103050 A AR P970103050A AR 007828 A1 AR007828 A1 AR 007828A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical compositions
piridilpirrol
same
compositions containing
preparation procedure
Prior art date
Application number
ARP970103050A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR007828A1 publication Critical patent/AR007828A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

Un compuesto derivado de piridil pirrol de fórmula (I) y sus sales farmacéuticamente aceptables, donde R1, R2, R3, R4, R5 y m son tal como sedefinen en la reivindicación 1. También aporta procedimientos para la preparación delmis mo, útil en el tratamiento de enfermedades en las queintervienen moléculas de adhesión celular (CAMs) y composiciones farmacéuticas para usarse en tal terapia.
ARP970103050A 1996-07-11 1997-07-08 Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos AR007828A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9600671 1996-07-11

Publications (1)

Publication Number Publication Date
AR007828A1 true AR007828A1 (es) 1999-11-24

Family

ID=11004451

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103050A AR007828A1 (es) 1996-07-11 1997-07-08 Compuestos derivados de piridilpirrol, procedimiento de preparacion y composiciones farmaceuticas conteniendo los mismos

Country Status (14)

Country Link
US (1) US6417202B1 (es)
EP (1) EP0912548A1 (es)
AP (1) AP9701041A0 (es)
AR (1) AR007828A1 (es)
AU (1) AU3044197A (es)
BR (1) BR9710352A (es)
CA (1) CA2260213C (es)
HN (1) HN1997000090A (es)
HR (1) HRP970378A2 (es)
ID (1) ID19476A (es)
MA (1) MA26433A1 (es)
PA (1) PA8432901A1 (es)
TN (1) TNSN97119A1 (es)
WO (1) WO1998002430A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6608060B1 (en) 1996-12-18 2003-08-19 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US5945418A (en) * 1996-12-18 1999-08-31 Vertex Pharmaceuticals Incorporated Inhibitors of p38
US6147080A (en) * 1996-12-18 2000-11-14 Vertex Pharmaceuticals Incorporated Inhibitors of p38
PT853083E (pt) * 1997-01-06 2001-12-28 Pfizer Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica
FR2771412B1 (fr) * 1997-11-26 2000-04-28 Adir Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1162151C (zh) * 1998-01-14 2004-08-18 日本新药株式会社 钾通道激活剂
AU3953899A (en) * 1998-05-27 1999-12-13 Nippon Shinyaku Co. Ltd. Cyclooxygenase-2 inhibitors
AU4315100A (en) * 1999-04-28 2000-11-17 Sankyo Company Limited Preventive or inhibitory agents for hepatopathy
IL146465A0 (en) 1999-05-14 2002-07-25 Ortho Mcneil Pharm Inc Substituted 3-pyridyl-4-arylpyrroles and related therapeutic and prophylactic methods
EP1652839A3 (en) * 1999-10-28 2006-07-05 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
GB0003154D0 (en) * 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
GB0016453D0 (en) * 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
EP1352906A4 (en) * 2001-01-18 2004-06-16 Sankyo Co COMPOSITIONS FOR PREVENTION OR TREATMENT OF LIVER DISEASES
US7056917B2 (en) * 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
WO2002087589A1 (fr) * 2001-04-26 2002-11-07 Daiichi Pharmaceutical Co., Ltd. Medicament permettant d'inhiber une pompe d'elimination de medicament
SE0102616D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
SE0102617D0 (sv) 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
AU2002331179B2 (en) 2001-08-30 2008-04-17 F. Hoffmann-La Roche Ag Aminopyrrole compounds as antiinflammatory agents
JP2006514043A (ja) * 2002-12-20 2006-04-27 ファルマシア・コーポレーション マイトジェン活性化タンパク質キナーゼ−活性化タンパク質キナーゼ−２を阻害する化合物
SE0300092D0 (sv) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300091D0 (sv) 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
US20050043346A1 (en) * 2003-08-08 2005-02-24 Pharmacia Italia S.P.A. Pyridylpyrrole derivatives active as kinase inhibitors
CN1942190A (zh) * 2004-02-20 2007-04-04 阿斯利康(瑞典)有限公司 用作促性腺激素释放激素(GnRH)拮抗剂的吡咯衍生物
JP5237111B2 (ja) * 2005-12-19 2013-07-17 シンジェンタ リミテッド 殺菌剤としての置換型芳香族複素環式化合物
US7618982B2 (en) * 2005-12-19 2009-11-17 Nerviano Medical Sciences S.R.L. Heteroarylpyrrolopyridinones active as kinase inhibitors
MX2008012422A (es) 2006-03-27 2008-10-09 Nerviano Medical Sciences Srl Derivados de furano y tiofeno, pirrol substituido con pirimidinil y piridil como inhibidores de cinasa.
CN101516874A (zh) 2006-09-21 2009-08-26 诺瓦提斯公司 用于治疗细胞因子介导的疾病的吡咯衍生物
EP2838881B1 (en) 2012-04-20 2018-08-08 AbbVie Inc. Isoindolone derivatives
CN104379573A (zh) * 2012-04-20 2015-02-25 艾伯维公司 异吲哚酮衍生物
WO2014165127A1 (en) * 2013-03-12 2014-10-09 Abbvie Inc. Pyrrole amide inhibitors
AR100886A1 (es) 2014-06-17 2016-11-09 Bayer Pharma AG 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
CN108602820A (zh) * 2015-12-16 2018-09-28 拜耳制药股份公司 杂-1,5,6,7-四氢-4h-吲哚-4-酮类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356897A (en) 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines
EP0871444A4 (en) * 1995-08-10 1999-01-13 Merck & Co Inc 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF
JP3294616B2 (ja) * 1995-08-10 2002-06-24 メルク エンド カンパニー インコーポレーテッド ２−置換アリールピロール、このような化合物を含む組成物及び使用方法
WO1997016441A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997016426A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997016442A1 (en) 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use

Also Published As

Publication number Publication date
US6417202B1 (en) 2002-07-09
US20020049235A1 (en) 2002-04-25
BR9710352A (pt) 1999-08-17
ID19476A (id) 1998-07-16
WO1998002430A1 (en) 1998-01-22
PA8432901A1 (es) 2000-05-24
EP0912548A1 (en) 1999-05-06
TNSN97119A1 (fr) 2005-03-15
CA2260213A1 (en) 1998-01-22
AU3044197A (en) 1998-02-09
AP9701041A0 (en) 1999-01-10
HN1997000090A (es) 1997-12-26
CA2260213C (en) 2005-03-29
MA26433A1 (fr) 2004-12-20
HRP970378A2 (en) 1998-08-31

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