BR9713808A - Composto. - Google Patents

Composto.

Info

Publication number
BR9713808A
BR9713808A BR9713808-8A BR9713808A BR9713808A BR 9713808 A BR9713808 A BR 9713808A BR 9713808 A BR9713808 A BR 9713808A BR 9713808 A BR9713808 A BR 9713808A
Authority
BR
Brazil
Prior art keywords
lower alkyl
compounds
formulawhereinar
andr1
andr3
Prior art date
Application number
BR9713808-8A
Other languages
English (en)
Inventor
Jun Yuan
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of BR9713808A publication Critical patent/BR9713808A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"COMPOSTO". Esta invenção engloba compostos de fórmula (I): em que A representa um grupo arila mono-, di ou tri-substituído, onde pelo menos uma posição em Ar orto para o ponto de fixação para o anel pirazol é substituída; e R~ 1~ representa alquila inferior; R~ 2~ é hidrogênio ou alquila inferior; e R~ 3~ e R~ 4~ independentemente representam substituintes orgânicos e inorgânicos, cujos compostos são agonistas parciais altamente seletivos ou antagonistas em receptores CRF~ 1~ humanos e são utilizáveis no diagnóstico e tratamento de distúrbios relacionados com estresse de tratamentos, como distúrbio de estresse pós-traumático (PTSD) assim como depressão, dor de cabeça e ansiedade.
BR9713808-8A 1996-12-31 1997-12-23 Composto. BR9713808A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/775,404 US5723608A (en) 1996-12-31 1996-12-31 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
PCT/US1997/024172 WO1998029413A1 (en) 1996-12-31 1997-12-23 3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS

Publications (1)

Publication Number Publication Date
BR9713808A true BR9713808A (pt) 2000-01-25

Family

ID=25104303

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713808-8A BR9713808A (pt) 1996-12-31 1997-12-23 Composto.

Country Status (16)

Country Link
US (2) US5723608A (pt)
EP (1) EP0960110B8 (pt)
JP (1) JP2001507705A (pt)
KR (1) KR20000069827A (pt)
CN (1) CN1100779C (pt)
AT (1) ATE214701T1 (pt)
AU (1) AU738324B2 (pt)
BR (1) BR9713808A (pt)
CA (1) CA2276610A1 (pt)
DE (1) DE69711241T2 (pt)
ES (1) ES2172830T3 (pt)
HK (1) HK1025958A1 (pt)
IL (1) IL130680A0 (pt)
NO (1) NO993240L (pt)
NZ (1) NZ336529A (pt)
WO (1) WO1998029413A1 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094782B1 (en) * 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
US6613777B1 (en) 1998-03-06 2003-09-02 Chen Chen CRF antagonistic pyrazolo[4,3-b]pyridines
KR20010080402A (ko) 1998-11-12 2001-08-22 추후기재 Ｃｒｆ 수용체 길항제 및 그와 관련된 방법
ATE225349T1 (de) 1998-11-12 2002-10-15 Neurocrine Biosciences Inc Crf rezeptor-antagonisten und darauf bezogene methoden
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
EP1392692B1 (en) 2001-03-27 2006-11-15 Neurogen Corporation (oxo-pyrazolo¬1,5a|pyrimidin-2-yl)alkyl-carboxamides
EP1348707B1 (en) * 2002-03-28 2010-08-25 Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
TW200400034A (en) * 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
US7268133B2 (en) * 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
EP1656379B1 (en) * 2003-08-15 2007-01-10 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
WO2005019222A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
EP1903045A1 (en) * 2005-05-27 2008-03-26 Mitsubishi Tanabe Pharma Corporation Pyrazolopyrimidine derivative
CA2615946A1 (en) * 2005-07-22 2007-02-01 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
US9555032B2 (en) * 2007-06-13 2017-01-31 Research Development Foundation Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling
EA034193B1 (ru) 2011-04-21 2020-01-15 Оригенис Гмбх Гетероциклические соединения в качестве ингибиторов киназ
AU2012244550C1 (en) * 2011-04-21 2017-06-22 Origenis Gmbh Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors
WO2014060112A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
US10000482B2 (en) 2012-10-19 2018-06-19 Origenis Gmbh Kinase inhibitors
CN111233719B (zh) * 2020-02-27 2021-08-20 泰兴先先化工有限公司 α-肟基苯乙酮衍生物的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE210265C (pt) 1907-09-09
GB1103061A (en) * 1963-05-16 1968-02-14 Anson Units Ltd Shell mould sand blowing machines
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5063245A (en) * 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
TW336932B (en) * 1992-12-17 1998-07-21 Pfizer Amino-substituted pyrazoles
NZ256620A (en) * 1992-12-17 1996-05-28 Pfizer Pyrazole derivatives; compounds and pharmaceutical compositions containing them; intermediate compounds
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
RU2142946C1 (ru) * 1992-12-17 1999-12-20 Пфайзер Инк. Производные пиразола и фармацевтическая композиция, содержащая их
US6765008B1 (en) * 1992-12-17 2004-07-20 Pfizer Inc Pyrrolopyrimidines as CRF antagonists
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US5646152A (en) * 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
HRP950330A2 (en) * 1994-07-05 1997-10-31 Ciba Geigy Ag New herbicides
CA2194756A1 (en) 1995-05-12 1996-11-14 Jun Yuan Novel deazapurine derivatives; a new class of crf1 specific ligands
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
CZ244598A3 (cs) * 1996-02-07 1998-10-14 Janssen Pharmaceutica N.V. Pyrazolopyrimidiny jako antagonisty CRF receptoru
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

Also Published As

Publication number Publication date
IL130680A0 (en) 2000-06-01
EP0960110A1 (en) 1999-12-01
EP0960110B1 (en) 2002-03-20
CN1100779C (zh) 2003-02-05
JP2001507705A (ja) 2001-06-12
NO993240L (no) 1999-08-27
HK1025958A1 (en) 2000-12-01
EP0960110B8 (en) 2002-11-27
NO993240D0 (no) 1999-06-29
AU5811098A (en) 1998-07-31
ES2172830T3 (es) 2002-10-01
AU738324B2 (en) 2001-09-13
WO1998029413A1 (en) 1998-07-09
US6211187B1 (en) 2001-04-03
CN1246860A (zh) 2000-03-08
CA2276610A1 (en) 1998-07-09
NZ336529A (en) 2001-03-30
US5723608A (en) 1998-03-03
KR20000069827A (ko) 2000-11-25
DE69711241D1 (de) 2002-04-25
DE69711241T2 (de) 2002-12-12
ATE214701T1 (de) 2002-04-15

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]