ATE214701T1 - 3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden - Google Patents

3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden

Info

Publication number
ATE214701T1
ATE214701T1 AT97954301T AT97954301T ATE214701T1 AT E214701 T1 ATE214701 T1 AT E214701T1 AT 97954301 T AT97954301 T AT 97954301T AT 97954301 T AT97954301 T AT 97954301T AT E214701 T1 ATE214701 T1 AT E214701T1
Authority
AT
Austria
Prior art keywords
crf1
corticotropin
pyrimidine derivatives
specific ligands
trigger factor
Prior art date
Application number
AT97954301T
Other languages
English (en)
Inventor
Jun Yuan
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ATE214701T1 publication Critical patent/ATE214701T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97954301T 1996-12-31 1997-12-23 3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden ATE214701T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/775,404 US5723608A (en) 1996-12-31 1996-12-31 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
PCT/US1997/024172 WO1998029413A1 (en) 1996-12-31 1997-12-23 3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS

Publications (1)

Publication Number Publication Date
ATE214701T1 true ATE214701T1 (de) 2002-04-15

Family

ID=25104303

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97954301T ATE214701T1 (de) 1996-12-31 1997-12-23 3-aryl pyrazolo(4,3-d)pyrimidin derivaten; corticotropin auslösefaktor- (crf1) spezifischen liganden

Country Status (16)

Country Link
US (2) US5723608A (de)
EP (1) EP0960110B8 (de)
JP (1) JP2001507705A (de)
KR (1) KR20000069827A (de)
CN (1) CN1100779C (de)
AT (1) ATE214701T1 (de)
AU (1) AU738324B2 (de)
BR (1) BR9713808A (de)
CA (1) CA2276610A1 (de)
DE (1) DE69711241T2 (de)
ES (1) ES2172830T3 (de)
HK (1) HK1025958A1 (de)
IL (1) IL130680A0 (de)
NO (1) NO993240L (de)
NZ (1) NZ336529A (de)
WO (1) WO1998029413A1 (de)

Families Citing this family (24)

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US7094782B1 (en) * 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
AU2931099A (en) * 1998-03-06 1999-09-20 Janssen Pharmaceutica N.V. Crf antagonistic pyrazolo(4,3-b)pyridines
TR200102178T2 (tr) 1998-11-12 2002-01-21 Neurocrine Biosciences, Inc. CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.
JP2002529465A (ja) 1998-11-12 2002-09-10 ニューロクライン バイオサイエンシーズ， インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびｃｒｆレセプターアンタゴニストに関する方法
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
CA2441926A1 (en) 2001-03-27 2002-10-03 Neurogen Corporation (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
ATE478872T1 (de) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
TW200400034A (en) * 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
US7268133B2 (en) * 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
WO2005019222A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
AU2004266227A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine NMDA/NR2B antagonists
WO2006126718A1 (ja) * 2005-05-27 2006-11-30 Tanabe Seiyaku Co., Ltd. ピラゾロピリミジン誘導体
WO2007013964A1 (en) * 2005-07-22 2007-02-01 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
EP2167094A2 (de) * 2007-06-13 2010-03-31 Research Development Foundation Verfahren zur behandlung und prävention von tauopathien und amyloid-beta-amyloidose durch modulierung der crf-rezeptor-signalgebung
AU2012244549B2 (en) 2011-04-21 2017-04-20 Origenis Gmbh Heterocyclic compounds as kinase inhibitors
US9802937B2 (en) * 2011-04-21 2017-10-31 Origenis Gmbh Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors
WO2014060112A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
WO2014060113A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Novel kinase inhibitors
CN111233719B (zh) * 2020-02-27 2021-08-20 泰兴先先化工有限公司 α-肟基苯乙酮衍生物的制备方法

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Publication number Priority date Publication date Assignee Title
DE210265C (de) 1907-09-09
GB1103061A (en) * 1963-05-16 1968-02-14 Anson Units Ltd Shell mould sand blowing machines
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5063245A (en) * 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
AU690079B2 (en) * 1992-12-17 1998-04-23 Pfizer Inc. Substituted pyrazoles as CRF antagonists
EP0674624B1 (de) * 1992-12-17 1999-01-20 Pfizer Inc. Pyrazole mit crf antagonistischer aktivität
BR9307646A (pt) * 1992-12-17 1999-05-25 Pfizer Pirrolopirimidinas como antagonistas de crf
TW336932B (en) * 1992-12-17 1998-07-21 Pfizer Amino-substituted pyrazoles
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US5646152A (en) 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
HRP950330A2 (en) * 1994-07-05 1997-10-31 Ciba Geigy Ag New herbicides
DE69603240T2 (de) * 1995-05-12 2000-01-05 Neurogen Corp., Branford Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
EP0880523B1 (de) * 1996-02-07 2006-08-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidine als crf rezeptor-antagonisten
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

Also Published As

Publication number Publication date
HK1025958A1 (en) 2000-12-01
CN1246860A (zh) 2000-03-08
BR9713808A (pt) 2000-01-25
NO993240D0 (no) 1999-06-29
AU738324B2 (en) 2001-09-13
US6211187B1 (en) 2001-04-03
DE69711241D1 (de) 2002-04-25
EP0960110B8 (de) 2002-11-27
NO993240L (no) 1999-08-27
CA2276610A1 (en) 1998-07-09
CN1100779C (zh) 2003-02-05
EP0960110B1 (de) 2002-03-20
ES2172830T3 (es) 2002-10-01
NZ336529A (en) 2001-03-30
US5723608A (en) 1998-03-03
IL130680A0 (en) 2000-06-01
DE69711241T2 (de) 2002-12-12
WO1998029413A1 (en) 1998-07-09
EP0960110A1 (de) 1999-12-01
AU5811098A (en) 1998-07-31
KR20000069827A (ko) 2000-11-25
JP2001507705A (ja) 2001-06-12

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