IL130680A0 - 3-aryl substituted pyrazolo (4,3-d) pyrimidine derivatives corticotrophin-releasing factor receptor (CRF1) specific ligands - Google Patents
3-aryl substituted pyrazolo (4,3-d) pyrimidine derivatives corticotrophin-releasing factor receptor (CRF1) specific ligandsInfo
- Publication number
- IL130680A0 IL130680A0 IL13068097A IL13068097A IL130680A0 IL 130680 A0 IL130680 A0 IL 130680A0 IL 13068097 A IL13068097 A IL 13068097A IL 13068097 A IL13068097 A IL 13068097A IL 130680 A0 IL130680 A0 IL 130680A0
- Authority
- IL
- Israel
- Prior art keywords
- crf1
- corticotrophin
- factor receptor
- aryl substituted
- pyrimidine derivatives
- Prior art date
Links
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 title 1
- 101800000414 Corticotropin Proteins 0.000 title 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title 1
- 229960000258 corticotropin Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 239000003488 releasing hormone Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 108091005471 CRHR1 Proteins 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/775,404 US5723608A (en) | 1996-12-31 | 1996-12-31 | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| PCT/US1997/024172 WO1998029413A1 (en) | 1996-12-31 | 1997-12-23 | 3-ARYL SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDINE DERIVATIVES; CORTICOTROPIN-RELEASING FACTOR RECEPTOR (CRF1) SPECIFIC LIGANDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL130680A0 true IL130680A0 (en) | 2000-06-01 |
Family
ID=25104303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13068097A IL130680A0 (en) | 1996-12-31 | 1997-12-23 | 3-aryl substituted pyrazolo (4,3-d) pyrimidine derivatives corticotrophin-releasing factor receptor (CRF1) specific ligands |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5723608A (de) |
| EP (1) | EP0960110B8 (de) |
| JP (1) | JP2001507705A (de) |
| KR (1) | KR20000069827A (de) |
| CN (1) | CN1100779C (de) |
| AT (1) | ATE214701T1 (de) |
| AU (1) | AU738324B2 (de) |
| BR (1) | BR9713808A (de) |
| CA (1) | CA2276610A1 (de) |
| DE (1) | DE69711241T2 (de) |
| ES (1) | ES2172830T3 (de) |
| IL (1) | IL130680A0 (de) |
| NO (1) | NO993240L (de) |
| NZ (1) | NZ336529A (de) |
| WO (1) | WO1998029413A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
| US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US7094782B1 (en) * | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| WO1999045007A1 (en) * | 1998-03-06 | 1999-09-10 | Janssen Pharmaceutica N.V. | Crf antagonistic pyrazolo[4,3-b]pyridines |
| DK1129096T3 (da) | 1998-11-12 | 2003-09-15 | Neurocrine Biosciences Inc | CRF-receptorantagonister og fremgangsmåder, der er relateret dertil |
| ES2180338T3 (es) | 1998-11-12 | 2003-02-01 | Neurocrine Biosciences Inc | Antagonistas del receptor de crf y metodos relacionados. |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| WO2002076987A1 (en) | 2001-03-27 | 2002-10-03 | Neurogen Corporation | (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides |
| ATE478872T1 (de) * | 2002-03-28 | 2010-09-15 | Ustav Ex Botan Av Cr V V I I O | Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung |
| TW200400034A (en) * | 2002-05-20 | 2004-01-01 | Bristol Myers Squibb Co | Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors |
| US7268133B2 (en) * | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
| EP1656379B1 (de) * | 2003-08-15 | 2007-01-10 | Merck & Co., Inc. | 4-cycloalkylaminopyrazolopyrimidin als nmda/nr2b-antagonisten |
| WO2005019222A1 (en) * | 2003-08-15 | 2005-03-03 | Merck & Co., Inc. | 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists |
| JPWO2006126718A1 (ja) * | 2005-05-27 | 2008-12-25 | 田辺三菱製薬株式会社 | ピラゾロピリミジン誘導体 |
| US7932257B2 (en) * | 2005-07-22 | 2011-04-26 | Sunesis Pharmaceuticals, Inc. | Substituted pyrazolo[4,3-d]pyrimidines as aurora kinase inhibitors |
| EP2167094A2 (de) * | 2007-06-13 | 2010-03-31 | Research Development Foundation | Verfahren zur behandlung und prävention von tauopathien und amyloid-beta-amyloidose durch modulierung der crf-rezeptor-signalgebung |
| AU2012244550C1 (en) * | 2011-04-21 | 2017-06-22 | Origenis Gmbh | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
| BR112013026744B1 (pt) | 2011-04-21 | 2022-05-17 | Origenis Gmbh | Compostos heterocíclicos, seus usos e seus intermediários, e composição farmacêutica |
| US9637491B2 (en) | 2012-10-19 | 2017-05-02 | Origenis Gmbh | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors |
| WO2014060113A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Novel kinase inhibitors |
| CN111233719B (zh) * | 2020-02-27 | 2021-08-20 | 泰兴先先化工有限公司 | α-肟基苯乙酮衍生物的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE210265C (de) | 1907-09-09 | |||
| GB1103061A (en) * | 1963-05-16 | 1968-02-14 | Anson Units Ltd | Shell mould sand blowing machines |
| US4495195A (en) * | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| US4605642A (en) * | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| US5063245A (en) * | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| US5712303A (en) * | 1992-12-17 | 1998-01-27 | Pfizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| ES2128544T3 (es) * | 1992-12-17 | 1999-05-16 | Pfizer | Pirrolopirimidinas como antagonistas del crf. |
| TW336932B (en) * | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| CA2150703C (en) * | 1992-12-17 | 2002-01-08 | Pfizer Limited | Substituted pyrazoles |
| TW574214B (en) * | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
| US5646152A (en) | 1994-06-15 | 1997-07-08 | Pfizer Inc. | Methods of administering CRF antagonists |
| HRP950330A2 (en) * | 1994-07-05 | 1997-10-31 | Ciba Geigy Ag | New herbicides |
| US5644057A (en) * | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| JPH10506126A (ja) * | 1995-05-12 | 1998-06-16 | ニューロゲン コーポレイション | 新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス |
| WO1997029109A1 (en) | 1996-02-07 | 1997-08-14 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as crf receptor antagonists |
| US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
-
1996
- 1996-12-31 US US08/775,404 patent/US5723608A/en not_active Expired - Fee Related
-
1997
- 1997-12-23 US US09/341,024 patent/US6211187B1/en not_active Expired - Fee Related
- 1997-12-23 JP JP53031298A patent/JP2001507705A/ja active Pending
- 1997-12-23 CA CA002276610A patent/CA2276610A1/en not_active Abandoned
- 1997-12-23 NZ NZ336529A patent/NZ336529A/xx unknown
- 1997-12-23 DE DE69711241T patent/DE69711241T2/de not_active Expired - Fee Related
- 1997-12-23 EP EP97954301A patent/EP0960110B8/de not_active Expired - Lifetime
- 1997-12-23 ES ES97954301T patent/ES2172830T3/es not_active Expired - Lifetime
- 1997-12-23 AU AU58110/98A patent/AU738324B2/en not_active Ceased
- 1997-12-23 WO PCT/US1997/024172 patent/WO1998029413A1/en not_active Ceased
- 1997-12-23 AT AT97954301T patent/ATE214701T1/de not_active IP Right Cessation
- 1997-12-23 CN CN97181857A patent/CN1100779C/zh not_active Expired - Fee Related
- 1997-12-23 IL IL13068097A patent/IL130680A0/xx unknown
- 1997-12-23 KR KR1019997005989A patent/KR20000069827A/ko not_active Ceased
- 1997-12-23 BR BR9713808-8A patent/BR9713808A/pt not_active Application Discontinuation
-
1999
- 1999-06-29 NO NO993240A patent/NO993240L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001507705A (ja) | 2001-06-12 |
| KR20000069827A (ko) | 2000-11-25 |
| EP0960110B1 (de) | 2002-03-20 |
| AU5811098A (en) | 1998-07-31 |
| ATE214701T1 (de) | 2002-04-15 |
| AU738324B2 (en) | 2001-09-13 |
| EP0960110B8 (de) | 2002-11-27 |
| US5723608A (en) | 1998-03-03 |
| DE69711241T2 (de) | 2002-12-12 |
| WO1998029413A1 (en) | 1998-07-09 |
| NZ336529A (en) | 2001-03-30 |
| CN1100779C (zh) | 2003-02-05 |
| DE69711241D1 (de) | 2002-04-25 |
| CN1246860A (zh) | 2000-03-08 |
| BR9713808A (pt) | 2000-01-25 |
| US6211187B1 (en) | 2001-04-03 |
| EP0960110A1 (de) | 1999-12-01 |
| ES2172830T3 (es) | 2002-10-01 |
| CA2276610A1 (en) | 1998-07-09 |
| NO993240L (no) | 1999-08-27 |
| HK1025958A1 (en) | 2000-12-01 |
| NO993240D0 (no) | 1999-06-29 |
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