CY1110512T1 - Πολυκυκλοαλκυλοπουρινες ως ανταγωνιστες υποδοχεων αδενοσινης - Google Patents

Πολυκυκλοαλκυλοπουρινες ως ανταγωνιστες υποδοχεων αδενοσινης

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Publication number
CY1110512T1
CY1110512T1 CY20091100543T CY091100543T CY1110512T1 CY 1110512 T1 CY1110512 T1 CY 1110512T1 CY 20091100543 T CY20091100543 T CY 20091100543T CY 091100543 T CY091100543 T CY 091100543T CY 1110512 T1 CY1110512 T1 CY 1110512T1
Authority
CY
Cyprus
Prior art keywords
polycyclocoylypurines
competitives
receptor
disorders
adenosine
Prior art date
Application number
CY20091100543T
Other languages
English (en)
Inventor
William F Kiesman
James E Dowling
Carol L Ensinger
Gnanasambandam Kumaravel
Russell C Petter
Ko Chung Lin
He Xi Chang
Original Assignee
Biogen Idec Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Ma Inc. filed Critical Biogen Idec Ma Inc.
Publication of CY1110512T1 publication Critical patent/CY1110512T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Η εφεύρεση βασίζεται στην ανακάλυψη ότι ενώσεις του Χημικού Τύπου I είναι αναπάντεχα σε μεγάλο βαθμό ισχυροί και επιλεκτικοί αναστολείς συγκεκριμένων υποτύπων υποδοχέων αδενοσίνης Α1. Ανταγωνιστές της αδενοσίνης Α1 μπορεί να είναι χρήσιμοι στην πρόληψη και/ή θεραπεία πολυάριθμων νόσων, όπου συμπεριλαμβάνονται καρδιακές και κυκλοφοριακές διαταραχές, εκφυλιστικές διαταραχές του κεντρικού νευρικού συστήματος, αναπνευστικές διαταραχές και πολλές νόσοι για τις οποίες είναι κατάλληλη μία διουρητική θεραπεία. Σε μία ενσωμάτωση εφεύρεση προβάλει μία ένωση του χημικού τύπου I:
CY20091100543T 1999-11-12 2009-05-21 Πολυκυκλοαλκυλοπουρινες ως ανταγωνιστες υποδοχεων αδενοσινης CY1110512T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16519199P 1999-11-12 1999-11-12
EP00978546A EP1230243B1 (en) 1999-11-12 2000-11-13 Poycyloalkylpurines as adenosine receptor antagonists

Publications (1)

Publication Number Publication Date
CY1110512T1 true CY1110512T1 (el) 2015-04-29

Family

ID=22597852

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100543T CY1110512T1 (el) 1999-11-12 2009-05-21 Πολυκυκλοαλκυλοπουρινες ως ανταγωνιστες υποδοχεων αδενοσινης

Country Status (35)

Country Link
US (5) US6649600B1 (el)
EP (3) EP2070930A1 (el)
JP (1) JP2003513982A (el)
KR (2) KR20080027971A (el)
CN (2) CN100390178C (el)
AT (1) ATE424403T1 (el)
AU (1) AU784556B2 (el)
BG (1) BG65720B1 (el)
BR (1) BR0015545A (el)
CA (1) CA2390496A1 (el)
CY (1) CY1110512T1 (el)
CZ (1) CZ20021614A3 (el)
DE (1) DE60041710D1 (el)
DK (1) DK1230243T3 (el)
EA (1) EA005211B1 (el)
EE (1) EE05365B1 (el)
ES (1) ES2323357T3 (el)
GE (1) GEP20043303B (el)
HK (1) HK1049155B (el)
IL (1) IL149487A0 (el)
IS (1) IS6379A (el)
ME (1) MEP42208A (el)
MX (1) MXPA02004796A (el)
NO (1) NO328956B1 (el)
NZ (2) NZ527917A (el)
PL (1) PL206890B1 (el)
PT (1) PT1230243E (el)
RS (1) RS50381B (el)
SI (1) SI1230243T1 (el)
SK (1) SK287311B6 (el)
TR (1) TR200201260T2 (el)
TW (1) TWI272270B (el)
UA (1) UA77391C2 (el)
WO (1) WO2001034610A1 (el)
ZA (1) ZA200203701B (el)

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UA77391C2 (en) 2006-12-15
NZ519426A (en) 2003-08-29
CN100390178C (zh) 2008-05-28
BG65720B1 (bg) 2009-08-31
EP2070930A1 (en) 2009-06-17
SK6632002A3 (en) 2003-02-04
EA005211B1 (ru) 2004-12-30
SK287311B6 (sk) 2010-06-07
PL206890B1 (pl) 2010-10-29
NO20022238L (no) 2002-07-12
EA200200560A1 (ru) 2002-10-31
ZA200203701B (en) 2004-02-23
US7579354B2 (en) 2009-08-25
EE05365B1 (et) 2010-12-15
ES2323357T3 (es) 2009-07-14
HK1049155B (zh) 2009-11-06
US20040067966A1 (en) 2004-04-08
US6649600B1 (en) 2003-11-18
MEP42208A (en) 2011-02-10
PT1230243E (pt) 2009-06-12
NO328956B1 (no) 2010-06-28
US20060252730A1 (en) 2006-11-09
CN1402729A (zh) 2003-03-12
ATE424403T1 (de) 2009-03-15
BR0015545A (pt) 2002-08-06
YU33802A (sh) 2006-01-16
HK1049155A1 (en) 2003-05-02
RS50381B (sr) 2009-11-10
PL356033A1 (en) 2004-06-14
AU1600001A (en) 2001-06-06
EE200200247A (et) 2003-06-16
US20070015732A1 (en) 2007-01-18
NZ527917A (en) 2005-03-24
KR20020049050A (ko) 2002-06-24
EP1230243B1 (en) 2009-03-04
MXPA02004796A (es) 2007-01-30
IS6379A (is) 2002-05-10
DE60041710D1 (de) 2009-04-16
DK1230243T3 (da) 2009-06-15
IL149487A0 (en) 2002-11-10
EP1230243A1 (en) 2002-08-14
US20090221821A1 (en) 2009-09-03
TWI272270B (en) 2007-02-01
KR20080027971A (ko) 2008-03-28
BG106762A (en) 2003-01-31
JP2003513982A (ja) 2003-04-15
KR100863761B1 (ko) 2008-10-16
AU784556B2 (en) 2006-05-04
SI1230243T1 (sl) 2009-08-31
CN101255162A (zh) 2008-09-03
CZ20021614A3 (cs) 2002-07-17
CA2390496A1 (en) 2001-05-17
NO20022238D0 (no) 2002-05-10
GEP20043303B (en) 2004-01-12
EP2305684A1 (en) 2011-04-06
TR200201260T2 (tr) 2002-09-23
WO2001034610A1 (en) 2001-05-17

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