DE60041710D1 - Polycycloalkylpurine als adenosinrezeptorantagonisten - Google Patents

Polycycloalkylpurine als adenosinrezeptorantagonisten

Info

Publication number
DE60041710D1
DE60041710D1 DE60041710T DE60041710T DE60041710D1 DE 60041710 D1 DE60041710 D1 DE 60041710D1 DE 60041710 T DE60041710 T DE 60041710T DE 60041710 T DE60041710 T DE 60041710T DE 60041710 D1 DE60041710 D1 DE 60041710D1
Authority
DE
Germany
Prior art keywords
polycycloalkylpurine
receptor antagonists
adenosine receptor
adenosine
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60041710T
Other languages
English (en)
Inventor
William F Kiesman
James E Dowling
Carol L Ensinger
Gnanasambandam Kumaravel
Russell C Petter
Ko Chung Lin
He Xi Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Idec Inc
Biogen Idec MA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Biogen Idec MA Inc filed Critical Biogen Idec Inc
Application granted granted Critical
Publication of DE60041710D1 publication Critical patent/DE60041710D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60041710T 1999-11-12 2000-11-13 Polycycloalkylpurine als adenosinrezeptorantagonisten Expired - Lifetime DE60041710D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16519199P 1999-11-12 1999-11-12
PCT/US2000/031058 WO2001034610A1 (en) 1999-11-12 2000-11-13 Polycycloalkylpurines as adenosine receptor antagonists

Publications (1)

Publication Number Publication Date
DE60041710D1 true DE60041710D1 (de) 2009-04-16

Family

ID=22597852

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60041710T Expired - Lifetime DE60041710D1 (de) 1999-11-12 2000-11-13 Polycycloalkylpurine als adenosinrezeptorantagonisten

Country Status (35)

Country Link
US (5) US6649600B1 (de)
EP (3) EP2070930A1 (de)
JP (1) JP2003513982A (de)
KR (2) KR100863761B1 (de)
CN (2) CN100390178C (de)
AT (1) ATE424403T1 (de)
AU (1) AU784556B2 (de)
BG (1) BG65720B1 (de)
BR (1) BR0015545A (de)
CA (1) CA2390496A1 (de)
CY (1) CY1110512T1 (de)
CZ (1) CZ20021614A3 (de)
DE (1) DE60041710D1 (de)
DK (1) DK1230243T3 (de)
EA (1) EA005211B1 (de)
EE (1) EE05365B1 (de)
ES (1) ES2323357T3 (de)
GE (1) GEP20043303B (de)
HK (1) HK1049155B (de)
IL (1) IL149487A0 (de)
IS (1) IS6379A (de)
ME (1) MEP42208A (de)
MX (1) MXPA02004796A (de)
NO (1) NO328956B1 (de)
NZ (2) NZ519426A (de)
PL (1) PL206890B1 (de)
PT (1) PT1230243E (de)
RS (1) RS50381B (de)
SI (1) SI1230243T1 (de)
SK (1) SK287311B6 (de)
TR (1) TR200201260T2 (de)
TW (1) TWI272270B (de)
UA (1) UA77391C2 (de)
WO (1) WO2001034610A1 (de)
ZA (1) ZA200203701B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS50381B (sr) * 1999-11-12 2009-11-10 Biogen Idec Ma Inc., Policikloalkilpurini kao adenozin receptor antagonisti
ATE353328T1 (de) * 1999-11-12 2007-02-15 Biogen Idec Inc Adenosin rezeptor antagonisten sowie methoden zu deren herstellung und verwendung
UA80258C2 (en) * 2001-09-06 2007-09-10 Biogen Inc Methods of treating pulmonary disease
DE10145193C1 (de) 2001-09-13 2003-03-13 Sachtler Gmbh & Co Kg Körpermontierbares Kameratragesystem mit einem multifunktionalen Verbund elektrischer Komponenten
EA200500005A1 (ru) * 2002-06-12 2005-06-30 Байоджен Айдек Ма Инк. Способ лечения повреждения, вызванного реперфузией после ишемии, с использованием антагонистов рецептора аденозина
US7495004B2 (en) 2002-06-17 2009-02-24 Glaxo Group Limited Purine derivatives as liver X receptor agonists
WO2004009594A2 (en) * 2002-07-19 2004-01-29 Aryx Therapeutics Xanthine derivatives having adenosine a1-receptor antagonist properties
US7202252B2 (en) 2003-02-19 2007-04-10 Endacea, Inc. A1 adenosine receptor antagonists
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
TW200500070A (en) * 2003-04-25 2005-01-01 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
WO2005009343A2 (en) 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
CN101248041B (zh) * 2005-06-17 2013-11-20 艾宝奇生物工艺有限公司 鞘氨醇激酶抑制剂
WO2007059330A2 (en) * 2005-11-17 2007-05-24 Medkura Inc. Cubane nucleoside analogs
AU2007235372A1 (en) * 2006-04-06 2007-10-18 Novacardia, Inc. Co-administration of adenosine A1 receptor antagonists and anticonvulsants
CN101085785B (zh) * 2006-06-06 2011-09-21 中国科学院上海药物研究所 用于治疗乙型肝炎的嘌呤类化合物及其制备方法和用途，以及包括该化合物的组合物
JP2009540003A (ja) * 2006-06-16 2009-11-19 ノヴァカーディア，インク． Ａａ１ｒａの低頻度投与を含む腎機能の長期間にわたる改善
US8685471B2 (en) * 2006-07-17 2014-04-01 Tyratech, Inc. Compositions and methods for controlling insects
WO2008121893A1 (en) * 2007-03-29 2008-10-09 Novacardia, Inc. Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
WO2008121882A1 (en) * 2007-03-29 2008-10-09 Novacardia, Inc. Improved methods of administration of adenosine a1 receptor antagonists
JP5603248B2 (ja) * 2007-12-21 2014-10-08 エンダセア， インコーポレイテッド Ａ１アデノシン受容体アンタゴニスト
US20100063071A1 (en) * 2008-06-13 2010-03-11 Kiesman William F Therapeutic compositions and related methods of use
WO2010011917A1 (en) * 2008-07-25 2010-01-28 Glaxosmithkline Llc SEH AND 11β-HSD1 DUAL INHIBITORS
WO2011063268A2 (en) 2009-11-19 2011-05-26 Biogen Idec Ma Inc Novel synthetic methods
EP2507280B1 (de) * 2009-12-04 2016-10-19 Commonwealth Scientific and Industrial Research Organisation Polymermaterialien
CN101709034B (zh) * 2009-12-14 2017-05-31 大连九信精细化工有限公司 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法
AR084457A1 (es) * 2010-12-22 2013-05-15 Lundbeck & Co As H Derivados de biciclo[3,2,1]octilamida
EP2723737A1 (de) 2011-06-27 2014-04-30 Kyorin Pharmaceutical Co., Ltd. Verbrückte bicyclische verbindungen zur behandlung von bakteriellen infektionen
US8962660B2 (en) 2013-03-14 2015-02-24 Bristol-Myers Squibb Company Oxabicyclo [2.2.2] acid GPR120 modulators
BR112015021386A2 (pt) * 2013-03-14 2017-07-18 Bristol Myers Squibb Co moduladores de ácido biciclo [2.2.2] gpr120
LT6401B (lt) 2015-07-28 2017-06-12 Vilniaus Universitetas Karboanhidrazės selektyvūs inhibitoriai
US10633315B2 (en) 2016-10-19 2020-04-28 Eastman Chemical Company Synthesis of bicyclo[2.2.2]octanes
WO2019018185A1 (en) 2017-07-15 2019-01-24 Arisan Therapeutics Inc. ENANTIOMERICALLY PURE ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTIONS
BR112020005174A2 (pt) 2017-09-14 2020-11-10 Daiichi Sankyo Company,Limited composto que possui estrutura cíclica
US11518726B2 (en) 2017-10-11 2022-12-06 Eastman Chemical Company Synthesis of bicyclo[2.2.2]octane derivatives
EA202091063A1 (ru) 2017-11-01 2020-09-18 Бристол-Маерс Сквибб Компани Мостиковые бициклические соединения в качестве модуляторов фарнезоидного х-рецептора
WO2020060914A1 (en) 2018-09-18 2020-03-26 Bristol-Myers Squibb Company Oxabicyclo acids as lpa antagonists
US10836899B2 (en) 2018-12-13 2020-11-17 Eastman Chemical Company Polyesters with specified crystallization half-times

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0011399A1 (de) 1978-11-11 1980-05-28 FISONS plc N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE3843117A1 (de) * 1988-12-22 1990-06-28 Boehringer Ingelheim Kg Neue xanthinderivate mit adenosin-antagonistischer wirkung
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
ES2152207T3 (es) 1989-10-20 2001-02-01 Kyowa Hakko Kogyo Kk Derivados condensados de la purina.
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
CA2061544A1 (en) 1991-02-25 1992-08-26 Fumio Suzuki Xanthine compounds
JPH04270222A (ja) * 1991-02-25 1992-09-25 Kyowa Hakko Kogyo Co Ltd 脳機能改善剤
JPH0559056A (ja) * 1991-02-25 1993-03-09 Kyowa Hakko Kogyo Co Ltd キサンチン誘導体
JPH04346986A (ja) * 1991-05-23 1992-12-02 Kyowa Hakko Kogyo Co Ltd トリチウム標識化されたキサンチン誘導体
DE69229257D1 (de) * 1991-11-08 1999-07-01 Kyowa Hakko Kogyo Kk Xanthinderivate zur Behandlung der Demenz
JP3115128B2 (ja) * 1991-11-08 2000-12-04 協和醗酵工業株式会社 キサンチン誘導体
US5336769A (en) * 1992-02-17 1994-08-09 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH0616668A (ja) * 1992-03-12 1994-01-25 Kyowa Hakko Kogyo Co Ltd キサンチン誘導体
US5342841A (en) * 1992-03-12 1994-08-30 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
TW252044B (de) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
US5384176A (en) * 1992-12-11 1995-01-24 Zimmerman; Richard C. Phenolic acid sulfate esters for prevention of marine biofouling
WO1994016702A1 (en) * 1993-01-26 1994-08-04 Kyowa Hakko Kogyo Co., Ltd. Remedy for irregular bowel movement
US5395836A (en) * 1993-04-07 1995-03-07 Kyowa Hakko Kogyo Co., Ltd. 8-tricycloalkyl xanthine derivatives
JP3729874B2 (ja) * 1993-04-07 2005-12-21 協和醗酵工業株式会社 キサンチン誘導体
US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
AU7675498A (en) * 1997-06-16 1999-01-04 Kyowa Hakko Kogyo Co. Ltd. Preventive and remedy for drug-induced nephropathy
WO1998057645A1 (fr) * 1997-06-16 1998-12-23 Kyowa Hakko Kogyo Co., Ltd. Medicament contre l'oedeme hepatique
DE19816857A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2295101C (en) 1998-04-24 2009-06-30 Biogen, Inc. Adenosine a1 receptor antagonist containing composition and method for restoring diuretic and renal function
EP0955301A3 (de) * 1998-04-27 2001-04-18 Pfizer Products Inc. 7-Aza-bicyclo[2.2.1]-heptan Derivate, deren Herstellung und Verwendung aufgrund ihrer Affinität für neuronale nikotinische Acetylcholin Rezeptoren
CA2336412C (en) 1998-07-02 2007-11-27 Junichi Shimada Medicament for treatment of diabetes
ATE353328T1 (de) * 1999-11-12 2007-02-15 Biogen Idec Inc Adenosin rezeptor antagonisten sowie methoden zu deren herstellung und verwendung
RS50381B (sr) * 1999-11-12 2009-11-10 Biogen Idec Ma Inc., Policikloalkilpurini kao adenozin receptor antagonisti
DE60304911D1 (de) 2002-02-25 2006-06-08 Eisai Co Ltd Xanthin-Derivate als DPP-IV-Inhibitoren
WO2004009594A2 (en) * 2002-07-19 2004-01-29 Aryx Therapeutics Xanthine derivatives having adenosine a1-receptor antagonist properties
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
PL1781657T3 (pl) * 2004-02-14 2013-08-30 Glaxosmithkline Ip Dev Ltd Leki o aktywności wobec receptora HM74A

Also Published As

Publication number Publication date
US7579354B2 (en) 2009-08-25
KR100863761B1 (ko) 2008-10-16
IS6379A (is) 2002-05-10
NO20022238L (no) 2002-07-12
BR0015545A (pt) 2002-08-06
YU33802A (sh) 2006-01-16
UA77391C2 (en) 2006-12-15
EP2305684A1 (de) 2011-04-06
CN101255162A (zh) 2008-09-03
JP2003513982A (ja) 2003-04-15
TWI272270B (en) 2007-02-01
EE200200247A (et) 2003-06-16
CN1402729A (zh) 2003-03-12
HK1049155B (zh) 2009-11-06
PL356033A1 (en) 2004-06-14
MXPA02004796A (es) 2007-01-30
RS50381B (sr) 2009-11-10
GEP20043303B (en) 2004-01-12
NO20022238D0 (no) 2002-05-10
CA2390496A1 (en) 2001-05-17
NZ519426A (en) 2003-08-29
SI1230243T1 (sl) 2009-08-31
EA005211B1 (ru) 2004-12-30
IL149487A0 (en) 2002-11-10
DK1230243T3 (da) 2009-06-15
US20040067966A1 (en) 2004-04-08
EA200200560A1 (ru) 2002-10-31
US20090221821A1 (en) 2009-09-03
ZA200203701B (en) 2004-02-23
WO2001034610A1 (en) 2001-05-17
CN100390178C (zh) 2008-05-28
CY1110512T1 (el) 2015-04-29
NO328956B1 (no) 2010-06-28
EP2070930A1 (de) 2009-06-17
AU784556B2 (en) 2006-05-04
TR200201260T2 (tr) 2002-09-23
PL206890B1 (pl) 2010-10-29
NZ527917A (en) 2005-03-24
AU1600001A (en) 2001-06-06
EP1230243A1 (de) 2002-08-14
US20060252730A1 (en) 2006-11-09
KR20080027971A (ko) 2008-03-28
PT1230243E (pt) 2009-06-12
EE05365B1 (et) 2010-12-15
US6649600B1 (en) 2003-11-18
EP1230243B1 (de) 2009-03-04
MEP42208A (en) 2011-02-10
SK287311B6 (sk) 2010-06-07
ES2323357T3 (es) 2009-07-14
BG65720B1 (bg) 2009-08-31
CZ20021614A3 (cs) 2002-07-17
ATE424403T1 (de) 2009-03-15
BG106762A (en) 2003-01-31
US20070015732A1 (en) 2007-01-18
HK1049155A1 (en) 2003-05-02
SK6632002A3 (en) 2003-02-04
KR20020049050A (ko) 2002-06-24

Similar Documents

Publication Publication Date Title
DE60041710D1 (de) Polycycloalkylpurine als adenosinrezeptorantagonisten
CY1106560T1 (el) Ανταγωνιστες υποδοχεα αδενοσινης και μεθοδοι κατασκευης και χρησης αυτων
DE60230683D1 (de) 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
WO2004092173A3 (en) A2a adenosine receptor antagonists
GB9815618D0 (en) Treatment of dyskinesia
DE60227576D1 (de) 3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
ATE256126T1 (de) 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen
PT889044E (pt) Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central
NO20053612D0 (no) 1,2,4-triaminobenzenderivater nyttige for behandling av forstyrrelser i sentralnervesystemet

Legal Events

Date Code Title Description
8364 No opposition during term of opposition