NO20022238L - Polycykloalkyl-puriner som adenosinreseptor-antagonister - Google Patents

Polycykloalkyl-puriner som adenosinreseptor-antagonister

Info

Publication number
NO20022238L
NO20022238L NO20022238A NO20022238A NO20022238L NO 20022238 L NO20022238 L NO 20022238L NO 20022238 A NO20022238 A NO 20022238A NO 20022238 A NO20022238 A NO 20022238A NO 20022238 L NO20022238 L NO 20022238L
Authority
NO
Norway
Prior art keywords
polycycloalkyl
purines
receptor antagonists
adenosine receptor
adenosine
Prior art date
Application number
NO20022238A
Other languages
English (en)
Other versions
NO328956B1 (no
NO20022238D0 (no
Inventor
William F Kiesman
James E Dowling
Carol L Ensinger
Gnanasambandam Kumaravel
Russell C Petter
He Xi Chang
Ko Chung Lin
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of NO20022238D0 publication Critical patent/NO20022238D0/no
Publication of NO20022238L publication Critical patent/NO20022238L/no
Publication of NO328956B1 publication Critical patent/NO328956B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20022238A 1999-11-12 2002-05-10 Adenosinreseptorantagonist NO328956B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16519199P 1999-11-12 1999-11-12
PCT/US2000/031058 WO2001034610A1 (en) 1999-11-12 2000-11-13 Polycycloalkylpurines as adenosine receptor antagonists

Publications (3)

Publication Number Publication Date
NO20022238D0 NO20022238D0 (no) 2002-05-10
NO20022238L true NO20022238L (no) 2002-07-12
NO328956B1 NO328956B1 (no) 2010-06-28

Family

ID=22597852

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022238A NO328956B1 (no) 1999-11-12 2002-05-10 Adenosinreseptorantagonist

Country Status (35)

Country Link
US (5) US6649600B1 (no)
EP (3) EP2070930A1 (no)
JP (1) JP2003513982A (no)
KR (2) KR100863761B1 (no)
CN (2) CN100390178C (no)
AT (1) ATE424403T1 (no)
AU (1) AU784556B2 (no)
BG (1) BG65720B1 (no)
BR (1) BR0015545A (no)
CA (1) CA2390496A1 (no)
CY (1) CY1110512T1 (no)
CZ (1) CZ20021614A3 (no)
DE (1) DE60041710D1 (no)
DK (1) DK1230243T3 (no)
EA (1) EA005211B1 (no)
EE (1) EE05365B1 (no)
ES (1) ES2323357T3 (no)
GE (1) GEP20043303B (no)
HK (1) HK1049155B (no)
IL (1) IL149487A0 (no)
IS (1) IS6379A (no)
ME (1) MEP42208A (no)
MX (1) MXPA02004796A (no)
NO (1) NO328956B1 (no)
NZ (2) NZ519426A (no)
PL (1) PL206890B1 (no)
PT (1) PT1230243E (no)
RS (1) RS50381B (no)
SI (1) SI1230243T1 (no)
SK (1) SK287311B6 (no)
TR (1) TR200201260T2 (no)
TW (1) TWI272270B (no)
UA (1) UA77391C2 (no)
WO (1) WO2001034610A1 (no)
ZA (1) ZA200203701B (no)

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JP4491344B2 (ja) 2002-06-17 2010-06-30 グラクソ グループ リミテッド 肝ｘ受容体アゴニストとしてのプリン誘導体
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TWI538905B (zh) * 2010-12-22 2016-06-21 Ｈ 朗德貝克公司 雙環［３．２．１］辛基醯胺衍生物及其用途
AU2012275499A1 (en) 2011-06-27 2013-12-19 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
ES2765973T3 (es) * 2013-03-14 2020-06-11 Bristol Myers Squibb Co Moduladores de GPR120 de ácido biciclo[2.2.2]
US8962660B2 (en) 2013-03-14 2015-02-24 Bristol-Myers Squibb Company Oxabicyclo [2.2.2] acid GPR120 modulators
LT6401B (lt) 2015-07-28 2017-06-12 Vilniaus Universitetas Karboanhidrazės selektyvūs inhibitoriai
US10633315B2 (en) 2016-10-19 2020-04-28 Eastman Chemical Company Synthesis of bicyclo[2.2.2]octanes
US11548893B2 (en) 2017-07-15 2023-01-10 Arisan Therapeutics Inc. Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection
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Also Published As

Publication number Publication date
ZA200203701B (en) 2004-02-23
RS50381B (sr) 2009-11-10
JP2003513982A (ja) 2003-04-15
CN101255162A (zh) 2008-09-03
US6649600B1 (en) 2003-11-18
MEP42208A (en) 2011-02-10
AU1600001A (en) 2001-06-06
KR20020049050A (ko) 2002-06-24
PL206890B1 (pl) 2010-10-29
SI1230243T1 (sl) 2009-08-31
UA77391C2 (en) 2006-12-15
US20040067966A1 (en) 2004-04-08
BG106762A (en) 2003-01-31
EP1230243A1 (en) 2002-08-14
US20060252730A1 (en) 2006-11-09
BG65720B1 (bg) 2009-08-31
EP2305684A1 (en) 2011-04-06
DK1230243T3 (da) 2009-06-15
EA200200560A1 (ru) 2002-10-31
DE60041710D1 (de) 2009-04-16
IL149487A0 (en) 2002-11-10
ATE424403T1 (de) 2009-03-15
SK287311B6 (sk) 2010-06-07
EA005211B1 (ru) 2004-12-30
HK1049155B (zh) 2009-11-06
EP1230243B1 (en) 2009-03-04
TR200201260T2 (tr) 2002-09-23
NO328956B1 (no) 2010-06-28
CN1402729A (zh) 2003-03-12
CN100390178C (zh) 2008-05-28
YU33802A (sh) 2006-01-16
WO2001034610A1 (en) 2001-05-17
US20070015732A1 (en) 2007-01-18
NZ519426A (en) 2003-08-29
US7579354B2 (en) 2009-08-25
IS6379A (is) 2002-05-10
AU784556B2 (en) 2006-05-04
CZ20021614A3 (cs) 2002-07-17
EP2070930A1 (en) 2009-06-17
NO20022238D0 (no) 2002-05-10
KR20080027971A (ko) 2008-03-28
SK6632002A3 (en) 2003-02-04
ES2323357T3 (es) 2009-07-14
US20090221821A1 (en) 2009-09-03
TWI272270B (en) 2007-02-01
CA2390496A1 (en) 2001-05-17
EE200200247A (et) 2003-06-16
GEP20043303B (en) 2004-01-12
BR0015545A (pt) 2002-08-06
NZ527917A (en) 2005-03-24
PL356033A1 (en) 2004-06-14
CY1110512T1 (el) 2015-04-29
EE05365B1 (et) 2010-12-15
PT1230243E (pt) 2009-06-12
HK1049155A1 (en) 2003-05-02
MXPA02004796A (es) 2007-01-30
KR100863761B1 (ko) 2008-10-16

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