ATE256126T1 - 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen - Google Patents

5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen

Info

Publication number
ATE256126T1
ATE256126T1 AT97909992T AT97909992T ATE256126T1 AT E256126 T1 ATE256126 T1 AT E256126T1 AT 97909992 T AT97909992 T AT 97909992T AT 97909992 T AT97909992 T AT 97909992T AT E256126 T1 ATE256126 T1 AT E256126T1
Authority
AT
Austria
Prior art keywords
pyrido
benzimidazole
heteroatom
oxo
treatment
Prior art date
Application number
AT97909992T
Other languages
English (en)
Inventor
Allen B Reitz
Alfonzo D Jordan
Pauline J Sanfilippo
Malcolm K Scott
Anna V Smith
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE256126T1 publication Critical patent/ATE256126T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97909992T 1996-10-07 1997-10-03 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen ATE256126T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2751196P 1996-10-07 1996-10-07
PCT/US1997/018045 WO1998015553A1 (en) 1996-10-07 1997-10-03 5-HETEROATOM-CONTAINING ALKYL SUBSTITUTED-3-OXO-PYRIDO(1,2-a) BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS

Publications (1)

Publication Number Publication Date
ATE256126T1 true ATE256126T1 (de) 2003-12-15

Family

ID=21838133

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97909992T ATE256126T1 (de) 1996-10-07 1997-10-03 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen

Country Status (13)

Country Link
US (1) US5817668A (de)
EP (1) EP0935598B1 (de)
JP (1) JP2001501949A (de)
AR (1) AR013844A1 (de)
AT (1) ATE256126T1 (de)
AU (1) AU719333B2 (de)
CA (1) CA2267943A1 (de)
DE (1) DE69726749T2 (de)
DK (1) DK0935598T3 (de)
ES (1) ES2212081T3 (de)
NZ (1) NZ335060A (de)
PT (1) PT935598E (de)
WO (1) WO1998015553A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922731A (en) * 1997-06-30 1999-07-13 Ortho Pharmaceutical Corporation 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
EP1023291B1 (de) * 1997-10-07 2004-05-26 Ortho-McNeil Pharmaceutical, Inc. Dipyridoimidazolderivate zur behandlung von störungen des zentralen nervensystems
EP1025101B1 (de) * 1997-10-07 2002-12-18 Ortho-McNeil Pharmaceutical, Inc. Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
US6177569B1 (en) 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
AU5691199A (en) * 1998-08-25 2000-03-14 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: gaba brain receptor ligands
AU779686B2 (en) 1999-08-02 2005-02-03 Ortho-Mcneil Pharmaceutical, Inc. C-6 ring-substituted pyrido(1,2-a)benzimidazole derivatives useful in treating central nervous system disorders
GB0008696D0 (en) 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
ATE443699T1 (de) * 2002-12-06 2009-10-15 Purdue Research Foundation Pyridine zur behandlung von verletztemsäugetiernervengewebe
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100262762B1 (ko) * 1992-08-19 2000-08-01 랄프 알. 팔로 중추신경계 질환의 치료에 유용한 3-옥소-피리도(1,2-알파)벤즈이미다졸-4-카복실 및 4-옥소-아제디노(1,2-알파)벤즈이미다졸-5-카복실 유도체
US5521200A (en) * 1993-12-30 1996-05-28 Ho; Winston 2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous system disorders

Also Published As

Publication number Publication date
PT935598E (pt) 2004-03-31
DK0935598T3 (da) 2004-03-29
WO1998015553A1 (en) 1998-04-16
JP2001501949A (ja) 2001-02-13
AU4747397A (en) 1998-05-05
EP0935598B1 (de) 2003-12-10
NZ335060A (en) 2000-05-26
US5817668A (en) 1998-10-06
DE69726749D1 (de) 2004-01-22
AR013844A1 (es) 2001-01-31
ES2212081T3 (es) 2004-07-16
CA2267943A1 (en) 1998-04-16
EP0935598A1 (de) 1999-08-18
AU719333B2 (en) 2000-05-04
DE69726749T2 (de) 2005-07-21

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