ATE256126T1 - 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen - Google Patents

5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen

Info

Publication number
ATE256126T1
ATE256126T1 AT97909992T AT97909992T ATE256126T1 AT E256126 T1 ATE256126 T1 AT E256126T1 AT 97909992 T AT97909992 T AT 97909992T AT 97909992 T AT97909992 T AT 97909992T AT E256126 T1 ATE256126 T1 AT E256126T1
Authority
AT
Austria
Prior art keywords
pyrido
benzimidazole
heteroatom
oxo
treatment
Prior art date
Application number
AT97909992T
Other languages
English (en)
Inventor
Allen B Reitz
Alfonzo D Jordan
Pauline J Sanfilippo
Malcolm K Scott
Anna V Smith
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE256126T1 publication Critical patent/ATE256126T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT97909992T 1996-10-07 1997-10-03 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen ATE256126T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2751196P 1996-10-07 1996-10-07
PCT/US1997/018045 WO1998015553A1 (en) 1996-10-07 1997-10-03 5-HETEROATOM-CONTAINING ALKYL SUBSTITUTED-3-OXO-PYRIDO(1,2-a) BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS

Publications (1)

Publication Number Publication Date
ATE256126T1 true ATE256126T1 (de) 2003-12-15

Family

ID=21838133

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97909992T ATE256126T1 (de) 1996-10-07 1997-10-03 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen

Country Status (13)

Country Link
US (1) US5817668A (de)
EP (1) EP0935598B1 (de)
JP (1) JP2001501949A (de)
AR (1) AR013844A1 (de)
AT (1) ATE256126T1 (de)
AU (1) AU719333B2 (de)
CA (1) CA2267943A1 (de)
DE (1) DE69726749T2 (de)
DK (1) DK0935598T3 (de)
ES (1) ES2212081T3 (de)
NZ (1) NZ335060A (de)
PT (1) PT935598E (de)
WO (1) WO1998015553A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922731A (en) * 1997-06-30 1999-07-13 Ortho Pharmaceutical Corporation 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
CA2305342A1 (en) * 1997-10-07 1999-04-15 Ortho-Mcneil Pharmaceutical, Inc. Novel heterocyclic derivatives useful in treating central nervous system disorders
DE69810340T2 (de) * 1997-10-07 2003-10-30 Ortho-Mcneil Pharmaceutical, Inc. Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
JP2002523399A (ja) * 1998-08-25 2002-07-30 ニューロゲン コーポレイション オキソ−ピリドイミダゾール−カルボキサミド：ｇａｂａ脳レセプタリガンド
US6177569B1 (en) 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
ES2260034T3 (es) * 1999-08-02 2006-11-01 Ortho-Mcneil Pharmaceutical, Inc. Derivados de pirido (1.2-a) bencimidazol sustituidos en c-6 utiles en el tratamiento de transtornos del sistema nervioso central.
GB0008696D0 (en) 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
EP1567497B1 (de) * 2002-12-06 2009-09-23 Purdue Research Foundation Pyridine zur behandlung von verletztemsäugetiernervengewebe

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ255821A (en) * 1992-08-19 1996-10-28 Mcneilab Inc 3-oxo-pyrido-(or 4-oxo-azepino)[1,2-a]benzimidazole-4(or 5)-carboxyl derivatives; medicament
US5521200A (en) * 1993-12-30 1996-05-28 Ho; Winston 2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous system disorders

Also Published As

Publication number Publication date
CA2267943A1 (en) 1998-04-16
DE69726749T2 (de) 2005-07-21
WO1998015553A1 (en) 1998-04-16
NZ335060A (en) 2000-05-26
PT935598E (pt) 2004-03-31
ES2212081T3 (es) 2004-07-16
AR013844A1 (es) 2001-01-31
AU719333B2 (en) 2000-05-04
EP0935598B1 (de) 2003-12-10
AU4747397A (en) 1998-05-05
JP2001501949A (ja) 2001-02-13
EP0935598A1 (de) 1999-08-18
US5817668A (en) 1998-10-06
DK0935598T3 (da) 2004-03-29
DE69726749D1 (de) 2004-01-22

Similar Documents

Publication Publication Date Title
DE69925571D1 (de) Sulphonamid-derivate zur behandlung von störungen des zentralnervensystems
NO20005884D0 (no) Kombinasjonsterapi for behandling av bipolare forstyrrelser
ATE308527T1 (de) Phenylamino-substituierte triicyclische derivate zur behandlung hyperproliferativer krankheiten
DE69625518D1 (de) Wirkstoff zur behandlung neurodegenerativer störungen
IS5113A (is) Notkun antagónista CB1-viðtaka til meðhöndlunar löngunartruflana
NO20005864D0 (no) Quinasoler til behandling av hjernesvulst
NO306977B1 (no) Anvendelse av tienol[1,5]benzodiazepin for behandling av tilstander i mave/tarmkanalen
DE69737402D1 (de) Vorrichtung zur Behandlung von neurodegenerativen Störungen
EE04280B1 (et) Imidasopürimidiinid ja imidasopüridiinid neuroloogiliste häirete käitlemiseks
ATE235481T1 (de) Substituierte benzopyranderivate zur behandlung von entzündungen
DE69936335D1 (de) Verwendung von morpholinol zur behandlung von sexuellen funktionsstörungen
UA27911C2 (uk) Засіб для лікування або запобігання фізіологічних розладів, які викликані надлишком тахікініну
IL155589A0 (en) Novel amidoalkyl-piperidine and amidoalkyl-piperazine derivatives useful for the treatment of nervous system disorders
AU4674797A (en) Phenylalaninol derivatives for the treatment of central nervous system disorders
ATE256126T1 (de) 5-heteroatom-alkyl substituierte 3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid derivate zur behandlung zentral nervöser system störungen
ID27214A (id) Triazolopiridina untuk pengobatan gangguan trombosis
DE69735417D1 (de) 2,5-dihydroxybenzylsulfonderivate zur behandlung von sexuellen störungen
EE200000391A (et) Triasiiniühendid kesknärvisüsteemihäirete raviks
ATE226071T1 (de) Antikonvulsive derivate zur behandlung von neuropathischem schmerz
ATE261434T1 (de) Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten
NO991734D0 (no) Pyrazolinoner for behandling av potensforstyrrelser
NO984432D0 (no) FremgangsmÕte for behandling av migrenesmerte
ATE287718T1 (de) Benzenesulfonamide derivate in kombination mit beta-blockern zur behandlung von störungen des autonomen nervensystems
NO984189D0 (no) Fremgangsmåte for behandling av bipolar forstyrrelse
NO952411D0 (no) Midler for behandling av metaboliske bensykdommer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0935598

Country of ref document: EP

REN Ceased due to non-payment of the annual fee