ES2172830T3 - Derivados 3-aril sustituidos de pirazolo(4,3-d)pirimidina; ligantes especificos del receptor del factor liberador de corticotropina (crf1). - Google Patents

Derivados 3-aril sustituidos de pirazolo(4,3-d)pirimidina; ligantes especificos del receptor del factor liberador de corticotropina (crf1).

Info

Publication number
ES2172830T3
ES2172830T3 ES97954301T ES97954301T ES2172830T3 ES 2172830 T3 ES2172830 T3 ES 2172830T3 ES 97954301 T ES97954301 T ES 97954301T ES 97954301 T ES97954301 T ES 97954301T ES 2172830 T3 ES2172830 T3 ES 2172830T3
Authority
ES
Spain
Prior art keywords
pirazolo
crf1
pyrimidine
substituted derivatives
release factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97954301T
Other languages
English (en)
Inventor
Jun Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ES2172830T3 publication Critical patent/ES2172830T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION ABARCA COMPUESTOS DE FORMULA (I), DONDE AR REPRESENTA UN GRUPO ARILO MONO, DI O TRISUSTITUIDO, DONDE AL MENOS UNA POSICION SOBRE EL ARILO SITUADO EN POSICION ORTO RESPECTO AL PUNTO DE UNION DEL ANILLO PIRAZOL, ESTA SUSTITUIDA; Y R 1 REPRESENTA ALQUILO INFERIOR; R 2 ES HIDR OGENO O ALQUILO INFERIOR; Y R 3 Y R 4 , INDEPENDIENTEMENTE, REPRESENTAN SUSTITUYENTES ORGANICOS E INORGANICOS. DICHOS COMPUESTOS SON AGONISTAS O ANTAGONISTAS PARCIALES ALTAMENTE SELECTIVOS DE LOS RECEPTORES HUMANOS CRF 1 , Y SON UTILES PARA EL DIAGNOSTICO Y TRATAMIENTO DE ALTERACIONES RELACIONADAS CON EL ESTRES, COMO LA ALTERACION DEL ESTRES POST-TRAUMATICO (PTSD), ASI COMO LA DEPRESION, DOLOR DE CABEZA Y ANSIEDAD.
ES97954301T 1996-12-31 1997-12-23 Derivados 3-aril sustituidos de pirazolo(4,3-d)pirimidina; ligantes especificos del receptor del factor liberador de corticotropina (crf1). Expired - Lifetime ES2172830T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/775,404 US5723608A (en) 1996-12-31 1996-12-31 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

Publications (1)

Publication Number Publication Date
ES2172830T3 true ES2172830T3 (es) 2002-10-01

Family

ID=25104303

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97954301T Expired - Lifetime ES2172830T3 (es) 1996-12-31 1997-12-23 Derivados 3-aril sustituidos de pirazolo(4,3-d)pirimidina; ligantes especificos del receptor del factor liberador de corticotropina (crf1).

Country Status (16)

Country Link
US (2) US5723608A (es)
EP (1) EP0960110B8 (es)
JP (1) JP2001507705A (es)
KR (1) KR20000069827A (es)
CN (1) CN1100779C (es)
AT (1) ATE214701T1 (es)
AU (1) AU738324B2 (es)
BR (1) BR9713808A (es)
CA (1) CA2276610A1 (es)
DE (1) DE69711241T2 (es)
ES (1) ES2172830T3 (es)
HK (1) HK1025958A1 (es)
IL (1) IL130680A0 (es)
NO (1) NO993240L (es)
NZ (1) NZ336529A (es)
WO (1) WO1998029413A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094782B1 (en) * 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
AU2931099A (en) * 1998-03-06 1999-09-20 Janssen Pharmaceutica N.V. Crf antagonistic pyrazolo(4,3-b)pyridines
TR200102178T2 (tr) 1998-11-12 2002-01-21 Neurocrine Biosciences, Inc. CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.
JP2002529465A (ja) 1998-11-12 2002-09-10 ニューロクライン バイオサイエンシーズ， インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびｃｒｆレセプターアンタゴニストに関する方法
US6432989B1 (en) 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
CA2441926A1 (en) 2001-03-27 2002-10-03 Neurogen Corporation (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
ATE478872T1 (de) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
TW200400034A (en) * 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
US7268133B2 (en) * 2003-04-23 2007-09-11 Pfizer, Inc. Patent Department Cannabinoid receptor ligands and uses thereof
WO2005019222A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine nmda/nr2b antagonists
AU2004266227A1 (en) * 2003-08-15 2005-03-03 Merck & Co., Inc. 4-cycloalkylaminopyrazolo pyrimidine NMDA/NR2B antagonists
WO2006126718A1 (ja) * 2005-05-27 2006-11-30 Tanabe Seiyaku Co., Ltd. ピラゾロピリミジン誘導体
WO2007013964A1 (en) * 2005-07-22 2007-02-01 Sunesis Pharmaceuticals, Inc. Pyrazolo pyrimidines useful as aurora kinase inhibitors
EP2167094A2 (en) * 2007-06-13 2010-03-31 Research Development Foundation Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating crf receptor signaling
AU2012244549B2 (en) 2011-04-21 2017-04-20 Origenis Gmbh Heterocyclic compounds as kinase inhibitors
US9802937B2 (en) * 2011-04-21 2017-10-31 Origenis Gmbh Substituted pyrazolo{4,3-D}pyrimidines as kinase inhibitors
WO2014060112A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
WO2014060113A1 (en) 2012-10-19 2014-04-24 Origenis Gmbh Novel kinase inhibitors
CN111233719B (zh) * 2020-02-27 2021-08-20 泰兴先先化工有限公司 α-肟基苯乙酮衍生物的制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE210265C (es) 1907-09-09
GB1103061A (en) * 1963-05-16 1968-02-14 Anson Units Ltd Shell mould sand blowing machines
US4495195A (en) * 1982-11-01 1985-01-22 Eli Lilly And Company Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
US4605642A (en) * 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5063245A (en) * 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
AU690079B2 (en) * 1992-12-17 1998-04-23 Pfizer Inc. Substituted pyrazoles as CRF antagonists
EP0674624B1 (en) * 1992-12-17 1999-01-20 Pfizer Inc. Pyrazoles having crf antagonist activity
BR9307646A (pt) * 1992-12-17 1999-05-25 Pfizer Pirrolopirimidinas como antagonistas de crf
TW336932B (en) * 1992-12-17 1998-07-21 Pfizer Amino-substituted pyrazoles
TW370529B (en) * 1992-12-17 1999-09-21 Pfizer Pyrazolopyrimidines
TW574214B (en) 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US5646152A (en) 1994-06-15 1997-07-08 Pfizer Inc. Methods of administering CRF antagonists
HRP950330A2 (en) * 1994-07-05 1997-10-31 Ciba Geigy Ag New herbicides
DE69603240T2 (de) * 1995-05-12 2000-01-05 Neurogen Corp., Branford Neue deazapurinderivate; eine neue klasse von crf1-spezifischen liganden
US5644057A (en) * 1995-05-12 1997-07-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
EP0880523B1 (en) * 1996-02-07 2006-08-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as crf receptor antagonists
US5723608A (en) * 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands

Also Published As

Publication number Publication date
HK1025958A1 (en) 2000-12-01
CN1246860A (zh) 2000-03-08
BR9713808A (pt) 2000-01-25
NO993240D0 (no) 1999-06-29
AU738324B2 (en) 2001-09-13
US6211187B1 (en) 2001-04-03
DE69711241D1 (de) 2002-04-25
EP0960110B8 (en) 2002-11-27
NO993240L (no) 1999-08-27
CA2276610A1 (en) 1998-07-09
CN1100779C (zh) 2003-02-05
EP0960110B1 (en) 2002-03-20
NZ336529A (en) 2001-03-30
US5723608A (en) 1998-03-03
IL130680A0 (en) 2000-06-01
DE69711241T2 (de) 2002-12-12
ATE214701T1 (de) 2002-04-15
WO1998029413A1 (en) 1998-07-09
EP0960110A1 (en) 1999-12-01
AU5811098A (en) 1998-07-31
KR20000069827A (ko) 2000-11-25
JP2001507705A (ja) 2001-06-12

Similar Documents

Publication Publication Date Title
ES2172830T3 (es) Derivados 3-aril sustituidos de pirazolo(4,3-d)pirimidina; ligantes especificos del receptor del factor liberador de corticotropina (crf1).
PE91798A1 (es) Pirrolicarboxanilidas condensadas: utiles como ligandos receptores
EA199700156A1 (ru) Производные индола как антагонисты рецептора 5-нт
EA200200560A1 (ru) Полициклоалкилпурины в качестве антагонистов аденозиновых рецепторов
AR027406A1 (es) Moduladores de receptores canabinoides, sus procesos de preparacion y uso de los moduladores de receptores canabinoides para el tratamiento de enfermedadesrespiratorias y no respiratorias.
BR0312758A (pt) Derivados de 1-heterociclilalquil-3-sulfonilazaindol ou -azaindazol como ligantes da 5-hidroxitriptamina-6
DE69331190D1 (de) Überbrückte azabicyclische derivate als substanz p antagonisten
DK0856003T3 (da) Heterocykliske analoger af 1,2,4-triazolo[1,5-c]pyrimidin med antagonistisk virkning på adenosin A2a-receptorer
PT1235787E (pt) Receptores agonistas beta2 adrenergicos
AR029199A1 (es) Derivados de adenosina n6 heterociclico 5'-tio- sustituidos agonistas a1 parciales o totales, sus usos, y sus composiciones farmaceuticas
PE20020970A1 (es) Derivados de imidazo-pirimidina como ligandos para los receptores de gaba
DE69626705D1 (de) A1 adenosin rezeptor agonisten und antagonisten
TR200301062T2 (tr) Adenosin reseptörü antagonistleri ve bu antagonistlerin yapım ve kullanım yöntemleri
BR0007864A (pt) Composto, e, uso de um composto
ES2150039T3 (es) Benzonitrilos como 5-ht agonistas y antagonistas.
ATE424194T1 (de) Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
PT729455E (pt) Arilpiperazinas derivadas de indol como ligados para os receptores 5ht1-like, 5ht1b e 5ht1d
ES2154470T3 (es) Derivados de tetrahidroisoquinolina y su uso farmaceutico.
PT628033E (pt) Derivados de benzodiazepina uteis como antagonistas dos receptores-cck
AU5614198A (en) Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
ATE341538T1 (de) Benzimidazolonderivate mit affinität zu serotonin-und dopaminrezeptoren
TR199801659T2 (xx) Yeni triazolopurinler, haz�rlama y�ntemi, ila� olarak kullan�m�.
MX9700305A (es) Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1.
DE50209113D1 (de) 1-allyl-ergotalkaloid-derivate- verfahren zu ihrer herstellung und ihre verwendung zur prophylaxe und therapie von migräne
MX9203518A (es) 9-amino-2-fenilbiciclo [3.3.1] nonanos y 9-amino-2-fenilbiciclo [3.3.1] non-2-enos y drogas que los contienen.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 960110

Country of ref document: ES