PE91798A1 - Pirrolicarboxanilidas condensadas: utiles como ligandos receptores - Google Patents

Pirrolicarboxanilidas condensadas: utiles como ligandos receptores

Info

Publication number
PE91798A1
PE91798A1 PE1997000632A PE00063297A PE91798A1 PE 91798 A1 PE91798 A1 PE 91798A1 PE 1997000632 A PE1997000632 A PE 1997000632A PE 00063297 A PE00063297 A PE 00063297A PE 91798 A1 PE91798 A1 PE 91798A1
Authority
PE
Peru
Prior art keywords
formula
halogen
phenyl
preferred
preference
Prior art date
Application number
PE1997000632A
Other languages
English (en)
Inventor
Pamela Albaugh
Alan Hutchison
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of PE91798A1 publication Critical patent/PE91798A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Multicomponent Fibers (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: "T" ES HALOGENO, OH, NO2, NH2 o ALCOXI INFERIOR, DE PREFERENCIA "T" ES H; "X" ES H, OH o ALQUILO INFERIOR, DE PREFERENCIA "X" ES H; "W" ES FENILO O FENILO SUSTITUIDO, DE PREFERENCIA HASTA DOS VECES SUSTITUIDO CON HALOGENO, HIDROXI, ALQUILO INFERIOR Y ALCOXI INFERIOR, ENTRE OTROS; EL ANILLO C ES UN RADICAL DE FORMULA (a), (b) (c) o (d), EN DONDE "Y" ES N o CR4; R3 ES H, FENILO O PIRIDILO, ENTRE OTROS; R4 ES HALOGENO o CF3, ENTRE OTROS; R5 Y R6 SON H, HALOGENO, ALQUILO INFERIOR o ALCOXI INFERIOR; DE PREFERENCIA EL ANILLO C ES UN RADICAL DE FORMULA (d), EN DONDE "Z" ES NR7 o CR8R9; n ES 1; 2; 3 o 4; DE PREFERENCIA 1 o 2; R7 ES COMO R3; R8 Y R9 SON DE PREFERENCIA METILO; SIENDO UN COMPUESTO (I) PREFERIDO EL DE FORMULA (Ia). TAMBIEN SE REFIEREN A COMPUESTOS DE FORMULA (DVII) EN DONDE: R3 Y R4 SON H o ALQUILO; "G" ES TIENILO, TIAZOLILO, PIRIDILO, NAFTIRIDINILO, QUINOLINILO O FENILO LOS CUALES SE ENCUENTRAN OPCIONALMENTE SUSTITUIDOS. ESTOS COMPUESTOS ACTUAN UNIENDOSE AL LUGAR DE UNION GABA EN EL RECEPTOR DE BENDIAZEPINA, POR LO QUE ESTE COMPUESTO PUEDE SER UTIL EN EL TRATAMIENTO Y DIAGNOSTICO DE LA ANSIEDAD, DEL SUENO Y DE LOS DESORDENES EPILEPTICOS, ENTRE OTROS
PE1997000632A 1996-07-16 1997-07-16 Pirrolicarboxanilidas condensadas: utiles como ligandos receptores PE91798A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/683,066 US5750702A (en) 1993-10-27 1996-07-16 Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands

Publications (1)

Publication Number Publication Date
PE91798A1 true PE91798A1 (es) 1999-01-07

Family

ID=24742434

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000632A PE91798A1 (es) 1996-07-16 1997-07-16 Pirrolicarboxanilidas condensadas: utiles como ligandos receptores

Country Status (10)

Country Link
US (2) US5750702A (es)
AU (2) AU2832897A (es)
CO (1) CO4900050A1 (es)
DZ (1) DZ2271A1 (es)
HR (1) HRP970385A2 (es)
MA (1) MA27120A1 (es)
PA (1) PA8434101A1 (es)
PE (1) PE91798A1 (es)
WO (2) WO1998002433A1 (es)
ZA (1) ZA976244B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0888300A1 (en) 1996-03-22 1999-01-07 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
ID24135A (id) 1997-11-13 2000-07-06 Pfizer Prod Inc Metode sintesa pirol amida
EP1048651B1 (en) * 1997-12-03 2003-05-14 Taisho Pharmaceutical Co., Ltd Nitrogen-containing tetracyclic compounds
US6103903A (en) * 1998-02-26 2000-08-15 Neurogen Corporation 4-(4-piperidylmethyhlamino) substituted heteroaryl fused pyridines: GABA brain receptor ligands
ES2243046T3 (es) 1998-02-26 2005-11-16 Neurogen Corporation Carboxamidas cicloalquil-4-oxonicotinicas sustituidas; ligandos de receptores gaba del cerebro.
JPH11279040A (ja) 1998-03-27 1999-10-12 Kao Corp 皮膚外用剤
GB9812038D0 (en) 1998-06-04 1998-07-29 Merck Sharp & Dohme Therapeutic compound
MXPA01011173A (es) * 1999-05-06 2002-04-24 Neurogen Corp 4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba.
US6375948B1 (en) * 1999-07-12 2002-04-23 Kao Corporation Treating method for suppressing hair growth
OA12015A (en) * 1999-08-31 2006-04-19 Neurogen Corp Fused pyrrolecarboxamides: gaba brain receptor ligands.
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
US7112594B2 (en) 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
CA2430841A1 (en) * 2000-12-04 2002-06-13 Pfizer Products Inc. Synthesis of fused pyrrolecarboxamides
US6861529B2 (en) * 2001-07-06 2005-03-01 Pfizer Inc Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives
US20060100196A1 (en) * 2001-09-24 2006-05-11 Andrea Gailunas Substituted amines for the treatment of alzheimer's disease
JP2005516901A (ja) * 2001-11-19 2005-06-09 ニューロジェン コーポレイション １Ｈ−ピロロ［３，２−ｂ］ピリジン−３−カルボン酸アミド化合物
US6673811B1 (en) * 2001-11-19 2004-01-06 Neurogen Corporation 1H-pyrrolo [3,2-b] pyridine-3-carboxylic acid amines as GABAA receptor ligands
WO2003066634A1 (en) * 2002-02-07 2003-08-14 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
US20040122218A1 (en) * 2002-12-20 2004-06-24 Sean Turner Pyrrolopyridine potassium channel openers
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) * 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
KR20090064418A (ko) 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
JP5373613B2 (ja) 2006-10-16 2013-12-18 バイオノミクス リミテッド 新規な抗不安薬化合物
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2014510065A (ja) 2011-03-02 2014-04-24 バイオノミックス リミテッド 治療薬としての新規な小分子
CN103649086A (zh) 2011-05-12 2014-03-19 生态学有限公司 制备萘啶的方法
EP3911651B1 (en) 2019-01-17 2024-01-10 ViiV Healthcare UK (No.4) Limited Process for preparing fostemsavir

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455943A (en) * 1966-10-21 1969-07-15 American Cyanamid Co Certain 5,8-dihydro-beta-carbolines
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3535927A1 (de) * 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
AU652968B2 (en) * 1990-10-09 1994-09-15 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5243049A (en) * 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
US5266698A (en) * 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands

Also Published As

Publication number Publication date
CO4900050A1 (es) 2000-03-27
AU2832897A (en) 1998-02-09
ZA976244B (en) 1999-01-21
AU3660497A (en) 1998-02-09
US5925770A (en) 1999-07-20
WO1998002420A1 (en) 1998-01-22
DZ2271A1 (fr) 2002-12-18
US5750702A (en) 1998-05-12
PA8434101A1 (es) 2000-05-24
WO1998002433A1 (en) 1998-01-22
MA27120A1 (fr) 2005-01-03
HRP970385A2 (en) 1998-08-31

Similar Documents

Publication Publication Date Title
PE91798A1 (es) Pirrolicarboxanilidas condensadas: utiles como ligandos receptores
DE69415614D1 (de) N-acylierte trizyklische Azaheteroringe verwendbar als Vasopressin-Antagonisten
ES2031513T3 (es) Quinazolindionas y piridopirimidinadionas.
DE69331190D1 (de) Überbrückte azabicyclische derivate als substanz p antagonisten
PE109598A1 (es) Pirrolcarboxamidas condensadas, utiles como ligandos de receptores cerebrales gaba
PE106499A1 (es) Antagonistas del receptor ccr-3
ES2147759T3 (es) Heterociclos no aromaticos sustituidos con aminometileno y uso como antagonistas de la sustancia p.
ES2059327T3 (es) Derivados de tetrahidronaftaleno y de indano, obtencion de los mismos y utilizacion en preparados farmaceuticos.
ES2172830T3 (es) Derivados 3-aril sustituidos de pirazolo(4,3-d)pirimidina; ligantes especificos del receptor del factor liberador de corticotropina (crf1).
ATE171447T1 (de) Benzimidazole derivate
EA200300716A1 (ru) Гетероциклилалкилиндольные или -азаиндольные соединения в качестве лиганд 5-гидрокситриптамина-6
CA2207784A1 (en) Certain pyrrolopyridine derivatives; novel crf1 specific ligands
ATE72563T1 (de) 3-amino-dihydro-(1>-benzopyrane und benzothiopyrane.
ATE63744T1 (de) 3-amino-dihydro-(1>-benzopyrane und benzothiopyrane.
CO4900047A1 (es) Amidas del acido 4-(n -benzoilamino)-penten-2-enoico que tienen actividad como antagonistas de neuroquinina
PE44199A1 (es) Benzo[e]isoindoles y benzo[h]isoquinolinas triciclicos
ATE269329T1 (de) Neue basische derivate von benz(e)isoindol-1-onen und pyrrolo(3,4-c)chinolin-1-onen mit 5-ht3- antagonistischer aktivität, ihre herstellung und ihre therapeutische verwendung
MX9700305A (es) Nuevos derivados de deazapurina; una clase de ligandos especificos del crf1.
ATE415390T1 (de) Neue aminopyridinderivate als mglur5-antagonisten
DE69907448D1 (de) Pyrido[2,3-b]indolizinderivate und aza analoge: crf1 spezifische liganden
ATE112256T1 (de) 9-amino-2-phenylbicyclo(3.3.1>nonane und 9-amino- 2-phenylbicyclo(3.3.1>-non-2-ene und diese enthaltende therapeutische mittel.
PE20040746A1 (es) Ciclobuten-1,2-dionas 3,4-di-sustituidas como ligandos del receptor de quimiocina cxc

Legal Events

Date Code Title Description
FC Refusal