CO4900047A1 - Amidas del acido 4-(n -benzoilamino)-penten-2-enoico que tienen actividad como antagonistas de neuroquinina - Google Patents

Amidas del acido 4-(n -benzoilamino)-penten-2-enoico que tienen actividad como antagonistas de neuroquinina

Info

Publication number
CO4900047A1
CO4900047A1 CO97048265A CO97048265A CO4900047A1 CO 4900047 A1 CO4900047 A1 CO 4900047A1 CO 97048265 A CO97048265 A CO 97048265A CO 97048265 A CO97048265 A CO 97048265A CO 4900047 A1 CO4900047 A1 CO 4900047A1
Authority
CO
Colombia
Prior art keywords
lower alkyl
benzoylamine
enoic
penten
activity
Prior art date
Application number
CO97048265A
Other languages
English (en)
Inventor
Gerspacher Marc
Andreas Von Sprecher
Robert Mah
Silvio Roggo
Stefan Stutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO4900047A1 publication Critical patent/CO4900047A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Abstract

Un compuesto de la fórmula I;en donde:R es fenilo que está insustituido o que está sustituido por 1, 2, ó 3 sustituyentes seleccionados a partir del grupo de halógeno, alquilo inferior, trifluorometilo, hidroxi, y alcoxi inferior,R1 es hidrógeno o alquilo inferior, R2 es hidrógeno, alquilo inferior, o fenilo que está insustituido o que está sustituido por 1, 2 ó 3 sustituyentes seleccionados a partir del grupo de halógeno, alquilo inferior, trifluorometilo, hidroxi, y alcoxi inferior, R3 es fenilo que está insustituido o que está sustituido por 1, 2, ó 3 sustituyentes seleccionados a partir del grupo de halógeno, alquilo inferior, trifluorometilo, hidroxi y alcoxi inferior; o es naftilo, 1H-indol-3-ilo, ó 1-alquilo inferior indol-3-ilo, R4 ´ y R4 " son cada uno independientemente del otro, hidrógeno o alquilo inferior, siendo cuando menos uno de los radicales R4 ´ y R4 " hidrógeno, R5 es cicloalquilo de 3 a 8 átomos de carbono, D-azacicloheptan-2-on-3-ilo, ó L-azacicloheptan-2-on-3-ilo: o una sal del mismo.
CO97048265A 1996-08-22 1997-08-21 Amidas del acido 4-(n -benzoilamino)-penten-2-enoico que tienen actividad como antagonistas de neuroquinina CO4900047A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH206196 1996-08-22

Publications (1)

Publication Number Publication Date
CO4900047A1 true CO4900047A1 (es) 2000-03-27

Family

ID=4225003

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97048265A CO4900047A1 (es) 1996-08-22 1997-08-21 Amidas del acido 4-(n -benzoilamino)-penten-2-enoico que tienen actividad como antagonistas de neuroquinina

Country Status (32)

Country Link
US (1) US6319917B1 (es)
EP (1) EP0923550B1 (es)
JP (1) JP3654908B2 (es)
KR (1) KR100467402B1 (es)
CN (1) CN1119328C (es)
AR (1) AR009266A1 (es)
AT (1) ATE224875T1 (es)
AU (1) AU721850B2 (es)
BR (1) BR9711350A (es)
CA (1) CA2264065C (es)
CO (1) CO4900047A1 (es)
CZ (1) CZ294233B6 (es)
DE (1) DE69715886T2 (es)
DK (1) DK0923550T3 (es)
ES (1) ES2184083T3 (es)
HK (1) HK1021372A1 (es)
HU (1) HU226395B1 (es)
ID (1) ID18059A (es)
IL (1) IL128631A (es)
MY (1) MY132550A (es)
NO (1) NO312292B1 (es)
NZ (1) NZ334736A (es)
PE (1) PE107498A1 (es)
PL (1) PL193731B1 (es)
PT (1) PT923550E (es)
RU (1) RU2185375C2 (es)
SI (1) SI0923550T1 (es)
SK (1) SK283991B6 (es)
TR (1) TR199900363T2 (es)
TW (1) TW438777B (es)
WO (1) WO1998007694A1 (es)
ZA (1) ZA977493B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281300B1 (en) * 1998-03-20 2001-08-28 Exxon Chemical Patents, Inc. Continuous slurry polymerization volatile removal
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
MXPA06004688A (es) 2003-10-27 2006-07-05 Novartis Ag Uso de antagonistas de neuroquinina en el tratamiento de incontinencia urinaria.
EP2279741A3 (en) * 2003-12-01 2011-06-01 Cambridge Enterprise Ltd. Caprolactams and their use as anti-inflammatory agents
GB0402679D0 (en) * 2004-02-06 2004-03-10 Novartis Ag Organic compounds
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
EP1938804A1 (en) * 2006-12-22 2008-07-02 Novartis AG Pharmaceutical formulation comprising neurokinin antagonist
CN101641099A (zh) 2007-01-24 2010-02-03 葛兰素集团有限公司 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
MX2011008878A (es) * 2009-02-24 2011-09-21 Novartis Ag Usos de antagonistas de los receptores de nk.
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472978A (en) 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP0716077A1 (de) * 1994-12-08 1996-06-12 Ciba-Geigy Ag Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren
EA002348B1 (ru) * 1995-02-22 2002-04-25 Новартис Аг Соединения 1-арил-2-ациламиноэтана и их применение в качестве антагонистов нейрокинина, в частности нейрокинина 1

Also Published As

Publication number Publication date
NO312292B1 (no) 2002-04-22
SI0923550T1 (en) 2003-02-28
JP2001503387A (ja) 2001-03-13
HK1021372A1 (en) 2000-06-09
CZ294233B6 (cs) 2004-11-10
CA2264065A1 (en) 1998-02-26
PL193731B1 (pl) 2007-03-30
US6319917B1 (en) 2001-11-20
ZA977493B (en) 1998-08-03
NO990786L (no) 1999-03-25
JP3654908B2 (ja) 2005-06-02
DE69715886T2 (de) 2003-05-15
CN1233238A (zh) 1999-10-27
KR20000068325A (ko) 2000-11-25
AR009266A1 (es) 2000-04-12
MY132550A (en) 2007-10-31
WO1998007694A1 (en) 1998-02-26
IL128631A (en) 2002-09-12
ATE224875T1 (de) 2002-10-15
EP0923550A1 (en) 1999-06-23
IL128631A0 (en) 2000-01-31
HU226395B1 (en) 2008-11-28
DE69715886D1 (de) 2002-10-31
NO990786D0 (no) 1999-02-19
SK283991B6 (sk) 2004-07-07
HUP0001165A3 (en) 2002-02-28
CN1119328C (zh) 2003-08-27
HUP0001165A2 (hu) 2000-11-28
ID18059A (id) 1998-02-26
BR9711350A (pt) 1999-08-17
RU2185375C2 (ru) 2002-07-20
TR199900363T2 (xx) 1999-04-21
EP0923550B1 (en) 2002-09-25
NZ334736A (en) 2000-09-29
PE107498A1 (es) 1999-01-28
AU4299397A (en) 1998-03-06
CZ58199A3 (cs) 1999-06-16
TW438777B (en) 2001-06-07
PT923550E (pt) 2003-01-31
AU721850B2 (en) 2000-07-13
SK22199A3 (en) 2000-02-14
CA2264065C (en) 2008-02-05
DK0923550T3 (da) 2003-01-06
KR100467402B1 (ko) 2005-01-24
ES2184083T3 (es) 2003-04-01
PL331740A1 (en) 1999-08-02

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