MX9702028A - Antagonistas de bradiquinina heterociclicos, sustituidos con fluoroalquilo y fluoroalcoxi, procedimientos para su preparacion y su utilizacion. - Google Patents
Antagonistas de bradiquinina heterociclicos, sustituidos con fluoroalquilo y fluoroalcoxi, procedimientos para su preparacion y su utilizacion.Info
- Publication number
- MX9702028A MX9702028A MX9702028A MX9702028A MX9702028A MX 9702028 A MX9702028 A MX 9702028A MX 9702028 A MX9702028 A MX 9702028A MX 9702028 A MX9702028 A MX 9702028A MX 9702028 A MX9702028 A MX 9702028A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- mean
- alkyl
- fluoroalcoxy
- bradiquinine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D257/12—Six-membered rings having four nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen derivados heterocíclicos de fluoroalquilo y fluoroalcoxi de la formula (I) con un efecto antagonista de bradiquinina (Ver Formula) en la que X1-X3 significan N o CR5, R1 y R2 significan H o halogeno, R3 y R4 significan H, halogeno, alquilo o alquenilo, R5 significa H, halogeno, alquilo (sustituido), O-R6, S-R6, NHR6, arilo (sustituido), aril (sustituido)-alquilo, -C(O)-OR6 o -C(O)-H, R6 Y R8 significan H, alquilo, alquenilo o aril-alquilo, R7 significa alquilo (sustituido) o alcoxi (sustituido), B significa un ácido aminocarboxílico, D significa alquenodiílo, alcanodiílo o (CH2)n-Yp-(CH2)m-; E significa oxígeno o azufre, Y significa oxígeno, azufre o NR8, n y m significan un numero de 0 - 3, o significa un numero de 1 - 3 y p significa 0 o 1, así como sus sales fisiologicamente compatibles y un procedimiento para su preparacion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19610784.9 | 1996-03-19 | ||
| DE19610784A DE19610784A1 (de) | 1996-03-19 | 1996-03-19 | Fluoralkyl- und Fluoralkoxysubstituierte heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9702028A true MX9702028A (es) | 1997-09-30 |
| MXPA97002028A MXPA97002028A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| DE59710191D1 (de) | 2003-07-10 |
| PL318924A1 (en) | 1997-09-29 |
| JPH107656A (ja) | 1998-01-13 |
| AU1628397A (en) | 1997-09-25 |
| ATE242215T1 (de) | 2003-06-15 |
| IL120477A0 (en) | 1997-07-13 |
| BR9701332A (pt) | 1998-08-18 |
| NO971238D0 (no) | 1997-03-18 |
| SI0796848T1 (en) | 2003-12-31 |
| SK34897A3 (en) | 1998-01-14 |
| NO971238L (no) | 1997-09-22 |
| EP0796848A1 (de) | 1997-09-24 |
| ID16274A (id) | 1997-09-18 |
| AR006261A1 (es) | 1999-08-11 |
| CZ81097A3 (en) | 1997-10-15 |
| ZA972328B (en) | 1997-09-19 |
| TR199700206A2 (xx) | 1997-10-21 |
| EP0796848B1 (de) | 2003-06-04 |
| DE19610784A1 (de) | 1997-09-25 |
| HUP9700595A1 (hu) | 2000-08-28 |
| US5859025A (en) | 1999-01-12 |
| JP4199315B2 (ja) | 2008-12-17 |
| ES2196207T3 (es) | 2003-12-16 |
| CA2199925A1 (en) | 1997-09-19 |
| KR970065522A (ko) | 1997-10-13 |
| HU9700595D0 (en) | 1997-05-28 |
| HRP970155A2 (en) | 1998-04-30 |
| PT796848E (pt) | 2003-08-29 |
| DK0796848T3 (da) | 2003-09-22 |
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