NO990786D0 - Acylaminoalkenylen-amidderivater som NK1 og NK2 antagonister - Google Patents

Acylaminoalkenylen-amidderivater som NK1 og NK2 antagonister

Info

Publication number
NO990786D0
NO990786D0 NO990786A NO990786A NO990786D0 NO 990786 D0 NO990786 D0 NO 990786D0 NO 990786 A NO990786 A NO 990786A NO 990786 A NO990786 A NO 990786A NO 990786 D0 NO990786 D0 NO 990786D0
Authority
NO
Norway
Prior art keywords
acylaminoalkenylene
antagonists
amide derivatives
amide
derivatives
Prior art date
Application number
NO990786A
Other languages
English (en)
Other versions
NO990786L (no
NO312292B1 (no
Inventor
Marc Gerspacher
Andreas Von Sprecher
Robert Mah
Silvio Roggo
Stefan Stutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO990786D0 publication Critical patent/NO990786D0/no
Publication of NO990786L publication Critical patent/NO990786L/no
Publication of NO312292B1 publication Critical patent/NO312292B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
NO19990786A 1996-08-22 1999-02-19 Acylaminoalkenylen-amidderivater som NK1- og NK2- antagonister, anvendelse derav, farmasöytiske preparater samtfremgangsmåte for fremstilling av derivatene NO312292B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH206196 1996-08-22
PCT/EP1997/004436 WO1998007694A1 (en) 1996-08-22 1997-08-13 Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists

Publications (3)

Publication Number Publication Date
NO990786D0 true NO990786D0 (no) 1999-02-19
NO990786L NO990786L (no) 1999-03-25
NO312292B1 NO312292B1 (no) 2002-04-22

Family

ID=4225003

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19990786A NO312292B1 (no) 1996-08-22 1999-02-19 Acylaminoalkenylen-amidderivater som NK1- og NK2- antagonister, anvendelse derav, farmasöytiske preparater samtfremgangsmåte for fremstilling av derivatene

Country Status (32)

Country Link
US (1) US6319917B1 (no)
EP (1) EP0923550B1 (no)
JP (1) JP3654908B2 (no)
KR (1) KR100467402B1 (no)
CN (1) CN1119328C (no)
AR (1) AR009266A1 (no)
AT (1) ATE224875T1 (no)
AU (1) AU721850B2 (no)
BR (1) BR9711350A (no)
CA (1) CA2264065C (no)
CO (1) CO4900047A1 (no)
CZ (1) CZ294233B6 (no)
DE (1) DE69715886T2 (no)
DK (1) DK0923550T3 (no)
ES (1) ES2184083T3 (no)
HK (1) HK1021372A1 (no)
HU (1) HU226395B1 (no)
ID (1) ID18059A (no)
IL (1) IL128631A (no)
MY (1) MY132550A (no)
NO (1) NO312292B1 (no)
NZ (1) NZ334736A (no)
PE (1) PE107498A1 (no)
PL (1) PL193731B1 (no)
PT (1) PT923550E (no)
RU (1) RU2185375C2 (no)
SI (1) SI0923550T1 (no)
SK (1) SK283991B6 (no)
TR (1) TR199900363T2 (no)
TW (1) TW438777B (no)
WO (1) WO1998007694A1 (no)
ZA (1) ZA977493B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281300B1 (en) * 1998-03-20 2001-08-28 Exxon Chemical Patents, Inc. Continuous slurry polymerization volatile removal
GB0010958D0 (en) * 2000-05-05 2000-06-28 Novartis Ag Organic compounds
GB0203061D0 (en) * 2002-02-08 2002-03-27 Novartis Ag Organic compounds
GB0224788D0 (en) * 2002-10-24 2002-12-04 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
MXPA06004688A (es) * 2003-10-27 2006-07-05 Novartis Ag Uso de antagonistas de neuroquinina en el tratamiento de incontinencia urinaria.
WO2005053702A2 (en) * 2003-12-01 2005-06-16 Cambridge University Technical Services Limited Anti-inflammatory agents
GB0402679D0 (en) * 2004-02-06 2004-03-10 Novartis Ag Organic compounds
GB0607532D0 (en) * 2006-04-13 2006-05-24 Novartis Ag Organic compounds
JO2630B1 (en) * 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
EP1938804A1 (en) * 2006-12-22 2008-07-02 Novartis AG Pharmaceutical formulation comprising neurokinin antagonist
WO2008090114A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
JP5425229B2 (ja) * 2009-02-24 2014-02-26 ノバルティス アーゲー Ｎｋ受容体アンタゴニストの使用
RU2697414C1 (ru) * 2018-05-11 2019-08-14 Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс" Новый антагонист тахикининовых рецепторов и его применение

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472978A (en) 1991-07-05 1995-12-05 Merck Sharp & Dohme Ltd. Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
US5217996A (en) 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
EP0716077A1 (de) * 1994-12-08 1996-06-12 Ciba-Geigy Ag Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren
ATE178886T1 (de) * 1995-02-22 1999-04-15 Novartis Erfind Verwalt Gmbh 1-aryl-2-acylamino-ethan-verbindungen und ihre verwendung als neurokinin- insbesondere als neurokinin-1-antagonisten

Also Published As

Publication number Publication date
KR20000068325A (ko) 2000-11-25
CN1233238A (zh) 1999-10-27
PE107498A1 (es) 1999-01-28
DK0923550T3 (da) 2003-01-06
SI0923550T1 (en) 2003-02-28
JP2001503387A (ja) 2001-03-13
RU2185375C2 (ru) 2002-07-20
TR199900363T2 (xx) 1999-04-21
DE69715886T2 (de) 2003-05-15
CZ294233B6 (cs) 2004-11-10
EP0923550B1 (en) 2002-09-25
HUP0001165A2 (hu) 2000-11-28
ID18059A (id) 1998-02-26
HK1021372A1 (en) 2000-06-09
DE69715886D1 (de) 2002-10-31
MY132550A (en) 2007-10-31
PL193731B1 (pl) 2007-03-30
ES2184083T3 (es) 2003-04-01
IL128631A0 (en) 2000-01-31
ZA977493B (en) 1998-08-03
CN1119328C (zh) 2003-08-27
CZ58199A3 (cs) 1999-06-16
JP3654908B2 (ja) 2005-06-02
IL128631A (en) 2002-09-12
US6319917B1 (en) 2001-11-20
HUP0001165A3 (en) 2002-02-28
AU4299397A (en) 1998-03-06
KR100467402B1 (ko) 2005-01-24
BR9711350A (pt) 1999-08-17
CA2264065C (en) 2008-02-05
PT923550E (pt) 2003-01-31
WO1998007694A1 (en) 1998-02-26
HU226395B1 (en) 2008-11-28
NZ334736A (en) 2000-09-29
CA2264065A1 (en) 1998-02-26
ATE224875T1 (de) 2002-10-15
EP0923550A1 (en) 1999-06-23
PL331740A1 (en) 1999-08-02
SK22199A3 (en) 2000-02-14
NO990786L (no) 1999-03-25
TW438777B (en) 2001-06-07
AU721850B2 (en) 2000-07-13
AR009266A1 (es) 2000-04-12
NO312292B1 (no) 2002-04-22
CO4900047A1 (es) 2000-03-27
SK283991B6 (sk) 2004-07-07

Similar Documents

Publication Publication Date Title
NO994906L (no) GnRH antagonister som er modifisert i stillinger 5 og 6
DK0832061T3 (da) Benzamidderivater og anvendelse deraf som vasopressin-antagonister
ATE271543T1 (de) N-substituierte 2-cyanopyrrolidine
DK0796846T3 (da) 2-Aryl-substituerede pyridiner
EE9600186A (et) Neurokiniini (tahhüülkiniini) antagonistid
FI970310A (fi) 4-indolijohdannaiset serotoniinin vaikuttaja- ja vastavaikuttaja-aineina
FI971685A (fi) Takykiniini-antagonisteja
NO991563D0 (no) N-substituerte azaheterosykliske forbindelser
DK0991658T3 (da) Dolastatin 15-derivater
NO990786D0 (no) Acylaminoalkenylen-amidderivater som NK1 og NK2 antagonister
NO991384D0 (no) Substituerte heterocykler som anti-tumormidler
NO996115L (no) Azetidinylpropylpiperidin-derivater, intermediater og anvendelse som tachykinin-antagonister
DK0871623T3 (da) 3-Azetinidylalkylpiperidiner eller -pyrrolidiner som tachykininantagonister
NO963331D0 (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
NO991564D0 (no) N-substituerte azaheterosykliske forbindelser
PT964867E (pt) Antagonistas da taquicinima
DE69709802D1 (de) Amythiamicin Amid-Derivate
BR9709960A (pt) N-(4-piridil)-tioamidas substituídas
KR970702876A (ko) 뉴로키닌 길항제(Neurokinine (tachykinine) antagonists)
DK0937040T3 (da) N-substituerede 2-cyanopyrrolidiner
FI941117A (fi) Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina
ID21408A (id) Turunan-turunan n- (4-karbamimido-fenil) -fenilglisinamid
FI964890A0 (fi) Bioterapeutisk kombination
FIU960619U0 (fi) Laitteisto
SE9604165D0 (sv) Antivirals

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees