CY1107928T1 - Ενωσεις υποκατεστημενης αμινοκινουκλιδινης και χρησις των ως συνδεσμικα μεσα δελτα-οπιοειδους υποδοχεως - Google Patents

Ενωσεις υποκατεστημενης αμινοκινουκλιδινης και χρησις των ως συνδεσμικα μεσα δελτα-οπιοειδους υποδοχεως

Info

Publication number
CY1107928T1
CY1107928T1 CY20081100467T CY081100467T CY1107928T1 CY 1107928 T1 CY1107928 T1 CY 1107928T1 CY 20081100467 T CY20081100467 T CY 20081100467T CY 081100467 T CY081100467 T CY 081100467T CY 1107928 T1 CY1107928 T1 CY 1107928T1
Authority
CY
Cyprus
Prior art keywords
delta
agents
opioid receptor
substituted
aminocinuclidine
Prior art date
Application number
CY20081100467T
Other languages
English (en)
Inventor
Robert E Boyd
Allen B Reitz
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of CY1107928T1 publication Critical patent/CY1107928T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Η παρούσα εφεύρεσις απευθύνεται προς ενώσεις υποκατεστημένης αμινοκινουκλιδίνης του τύπου (Ι)' εις τον οποίον (τύπον) (I): το Ar εκλέγεται εκ της ομάδος της συνισταμένης εξ'αρυλίου και ετεροαρυλίου' το n είναι ακέραιος αριθμός από 0 έως 2' χρήσιμοι ως διαμορφωταί δέλτα-οπιοειδούς (opioid) υποδοχέως, συναγωνισταί δέλτα-οπιοειδούς υποδοχέως χρήσιμοι ως αναλγητικά και ανταγωνισταί δέλτα-οπιοειδούς υποδοχέως χρήσιμοι ως ανοσοκατασταλτικά, αντιφλεγμονώδεις παράγοντες, παράγοντες δια την θεραπείαν νευρολογικών και ψυχιατρικών καταστάσεων, φάρμακα δια κατάχρησιν (εξάρτησιν) εκ φαρμάκου (ναρκωτικού) και αλκοόλης, και παράγοντες δια την θεραπείαν αναπνευστικών νόσων.
CY20081100467T 2002-10-15 2008-04-30 Ενωσεις υποκατεστημενης αμινοκινουκλιδινης και χρησις των ως συνδεσμικα μεσα δελτα-οπιοειδους υποδοχεως CY1107928T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41860302P 2002-10-15 2002-10-15
EP03776299A EP1558610B1 (en) 2002-10-15 2003-10-14 Substituted aminoquinuclidine compounds and their use as delta-opioid receptor ligands

Publications (1)

Publication Number Publication Date
CY1107928T1 true CY1107928T1 (el) 2013-09-04

Family

ID=32107953

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100467T CY1107928T1 (el) 2002-10-15 2008-04-30 Ενωσεις υποκατεστημενης αμινοκινουκλιδινης και χρησις των ως συνδεσμικα μεσα δελτα-οπιοειδους υποδοχεως

Country Status (13)

Country Link
US (1) US7179818B2 (el)
EP (1) EP1558610B1 (el)
JP (1) JP2006504754A (el)
AT (1) ATE387443T1 (el)
AU (1) AU2003284068A1 (el)
CA (1) CA2501552A1 (el)
CY (1) CY1107928T1 (el)
DE (1) DE60319405T2 (el)
DK (1) DK1558610T3 (el)
ES (1) ES2300626T3 (el)
PT (1) PT1558610E (el)
SI (1) SI1558610T1 (el)
WO (1) WO2004035574A2 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1638560A1 (en) 2003-06-20 2006-03-29 Eli Lilly And Company 3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
CN100549004C (zh) 2003-10-01 2009-10-14 阿得罗公司 螺环杂环衍生物及其应用方法
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1049676B1 (en) * 1997-12-24 2005-10-12 Ortho-Mcneil Pharmaceutical, Inc. 4- aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
EP1242421A1 (en) 1999-12-22 2002-09-25 Ortho-McNeil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1] octan-3-yl)] aminobenzoic acid derivatives

Also Published As

Publication number Publication date
SI1558610T1 (sl) 2008-08-31
US7179818B2 (en) 2007-02-20
PT1558610E (pt) 2008-04-18
DE60319405D1 (de) 2008-04-10
AU2003284068A8 (en) 2004-05-04
AU2003284068A1 (en) 2004-05-04
EP1558610B1 (en) 2008-02-27
ES2300626T3 (es) 2008-06-16
CA2501552A1 (en) 2004-04-29
WO2004035574A2 (en) 2004-04-29
DK1558610T3 (da) 2008-06-23
EP1558610A2 (en) 2005-08-03
DE60319405T2 (de) 2009-02-26
WO2004035574A8 (en) 2004-07-29
US20040110789A1 (en) 2004-06-10
WO2004035574A3 (en) 2004-06-03
ATE387443T1 (de) 2008-03-15
JP2006504754A (ja) 2006-02-09

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