DE69918046D1 - Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische Verwendung - Google Patents
Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische VerwendungInfo
- Publication number
- DE69918046D1 DE69918046D1 DE69918046T DE69918046T DE69918046D1 DE 69918046 D1 DE69918046 D1 DE 69918046D1 DE 69918046 T DE69918046 T DE 69918046T DE 69918046 T DE69918046 T DE 69918046T DE 69918046 D1 DE69918046 D1 DE 69918046D1
- Authority
- DE
- Germany
- Prior art keywords
- ones
- group
- isoindol
- benz
- quinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CMJIEPZGWACMSV-UHFFFAOYSA-N benzo[g]isoindol-1-one Chemical class C1=CC=CC2=C3C(=O)N=CC3=CC=C21 CMJIEPZGWACMSV-UHFFFAOYSA-N 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- SLUJFZCMMFFYRU-UHFFFAOYSA-N pyrrolo[3,4-c]quinolin-1-one Chemical class C1=CC=CC2=C3C(=O)N=CC3=CN=C21 SLUJFZCMMFFYRU-UHFFFAOYSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- -1 3-quinuclidyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000003474 anti-emetic effect Effects 0.000 abstract 1
- 239000002111 antiemetic agent Substances 0.000 abstract 1
- 229940125683 antiemetic agent Drugs 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITTO980871 | 1998-10-13 | ||
| IT1998TO000871A IT1303123B1 (it) | 1998-10-13 | 1998-10-13 | Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918046D1 true DE69918046D1 (de) | 2004-07-22 |
| DE69918046T2 DE69918046T2 (de) | 2005-07-14 |
Family
ID=11417108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918046T Expired - Fee Related DE69918046T2 (de) | 1998-10-13 | 1999-10-12 | Neue basische Derivate von Benz(e)isoindol-1-onen und Pyrrolo(3,4-c)chinolin-1-onen mit 5-HT3-antagonistischer Aktivität, ihre Herstellung und ihre therapeutische Verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6323216B1 (de) |
| EP (1) | EP1018512B1 (de) |
| JP (1) | JP2000119270A (de) |
| AT (1) | ATE269329T1 (de) |
| AU (1) | AU754739B2 (de) |
| CA (1) | CA2285817C (de) |
| DE (1) | DE69918046T2 (de) |
| ES (1) | ES2218930T3 (de) |
| IT (1) | IT1303123B1 (de) |
| PT (1) | PT1018512E (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8656101A (en) * | 2000-08-21 | 2002-03-04 | Univ Georgetown | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| EP1620435A1 (de) * | 2003-04-21 | 2006-02-01 | Pfizer Inc. | Imidazopyridine mit aktivität als 5-ht4 rezeptor agonist und 5ht3 rezeptor antagonist |
| SE0400970D0 (sv) | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| US8697722B2 (en) * | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| PL2326645T3 (pl) * | 2008-07-29 | 2013-04-30 | Acraf | Związek o aktywności serotoninergicznej, sposób jego otrzymywania i zawierająca go kompozycja farmaceutyczna |
| JP5840143B2 (ja) | 2010-01-11 | 2016-01-06 | アストライア セラピューティクス， エルエルシーＡｓｔｒａｅａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｌｃ | ニコチン性アセチルコリン受容体モジュレーター |
| WO2020097389A1 (en) * | 2018-11-09 | 2020-05-14 | Vivace Therapeutics, Inc. | Bicyclic compounds |
| KR102909464B1 (ko) | 2019-04-16 | 2026-01-09 | 비바체 테라퓨틱스, 인크. | 바이사이클릭 화합물 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5200413A (en) | 1987-01-05 | 1993-04-06 | Beecham Group P.L.C. | Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis |
| GB9009542D0 (en) * | 1990-04-27 | 1990-06-20 | Beecham Group Plc | Novel compounds |
| US5189041A (en) * | 1990-11-16 | 1993-02-23 | Syntex (U.S.A.) Inc. | Tricyclic 5-ht3 receptor antagonists |
| JPH06506443A (ja) * | 1991-01-09 | 1994-07-21 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | アザ二環式およびアザ三環式誘導体、その製法および中間体ならびに該化合物含有の医薬組成物 |
| US5260303A (en) | 1991-03-07 | 1993-11-09 | G. D. Searle & Co. | Imidazopyridines as serotonergic 5-HT3 antagonists |
| US5280028A (en) | 1992-06-24 | 1994-01-18 | G. D. Searle & Co. | Benzimidazole compounds |
| IT1265057B1 (it) | 1993-08-05 | 1996-10-28 | Dompe Spa | Tropil 7-azaindolil-3-carbossiamidi |
| WO1995009168A1 (en) | 1993-09-30 | 1995-04-06 | Tokyo Tanabe Company Limited | Indoline compound and 5-ht3 receptor antagonist containing the same as active ingredient |
| FR2710915B1 (fr) | 1993-10-04 | 1995-11-24 | Synthelabo | Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique. |
| EP0647639A1 (de) | 1993-10-11 | 1995-04-12 | Sanofi | Heteroarylpiperidinen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammenstellungen |
| US5399562A (en) | 1994-02-04 | 1995-03-21 | G. D. Searle & Co. | Indolones useful as serotonergic agents |
| GB9410441D0 (en) * | 1994-05-25 | 1994-07-13 | Erba Carlo Spa | Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation |
-
1998
- 1998-10-13 IT IT1998TO000871A patent/IT1303123B1/it active IP Right Grant
-
1999
- 1999-10-12 ES ES99120342T patent/ES2218930T3/es not_active Expired - Lifetime
- 1999-10-12 DE DE69918046T patent/DE69918046T2/de not_active Expired - Fee Related
- 1999-10-12 JP JP11289461A patent/JP2000119270A/ja active Pending
- 1999-10-12 AT AT99120342T patent/ATE269329T1/de not_active IP Right Cessation
- 1999-10-12 CA CA002285817A patent/CA2285817C/en not_active Expired - Fee Related
- 1999-10-12 AU AU53597/99A patent/AU754739B2/en not_active Ceased
- 1999-10-12 EP EP99120342A patent/EP1018512B1/de not_active Expired - Lifetime
- 1999-10-12 PT PT99120342T patent/PT1018512E/pt unknown
- 1999-10-13 US US09/417,098 patent/US6323216B1/en not_active Expired - Fee Related
-
2001
- 2001-10-02 US US09/967,972 patent/US6413978B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20020042426A1 (en) | 2002-04-11 |
| EP1018512B1 (de) | 2004-06-16 |
| US6413978B1 (en) | 2002-07-02 |
| AU5359799A (en) | 2000-04-20 |
| ES2218930T3 (es) | 2004-11-16 |
| AU754739B2 (en) | 2002-11-21 |
| US6323216B1 (en) | 2001-11-27 |
| JP2000119270A (ja) | 2000-04-25 |
| CA2285817A1 (en) | 2000-04-13 |
| DE69918046T2 (de) | 2005-07-14 |
| CA2285817C (en) | 2008-12-16 |
| ATE269329T1 (de) | 2004-07-15 |
| PT1018512E (pt) | 2004-08-31 |
| IT1303123B1 (it) | 2000-10-30 |
| EP1018512A1 (de) | 2000-07-12 |
| ITTO980871A1 (it) | 2000-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ROTTAPHARM S.P.A., MILANO, IT |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |